EKS-LOA-00174

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00174

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	433.7	3.3E-130	380	634	255

Status

Unreviewed

Ensembl Protein

ENSLAFP00000001356

UniProt Accession

G3SNX2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCQ

Gene Synonyms/Alias

PRKCQ;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000001626	ENSLAFP00000001356	ENSLAFT00000001625

Organism

Loxodonta africana

Functional Description

Protein Length

706

Protein Sequence
(FASTA)

MSPFLRIGLS NFDCGSCQPC QGEAVNPYCA VLVKEYVESE NGQMYVQKKP TMYPPWDSTF 60

DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEVWLELK PQGRMLMNAR 120

YFLEMSDTKD LSEFETEGFF ALHHRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180

WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240

SPTFCEHCGT LLWGLARQGL KCDACGMNVH HKCQTKVANL CGINQKLMAE ALAMIESTQQ 300

ARSLRDTEHI FREGPVEIGL PRSMKEETRL PYLPTPGKRE PQGISWDSPM DGMDKVCHPP 360

EPEPSIERPS IHLKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420

DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QICHKFDLCR 480

ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDARTNTFC 540

GTPDYIAPEI LLGQKYNHSV DWWTFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600

WLEKEAKDLL VKLFVREPEK RLGVRGDIRE HPLFQEINWE ELERKEIEPP FKPKVKSPYD 660

CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFINPG MERLIS 706

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p

Q: 380   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  439

         7899********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+++f++fqt+++lffv+ey+nGGdlm+hiq ++k++  ra+fyaaeiil+l+flh+kg

Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQICHKFDLCRATFYAAEIILGLQFLHSKG  499

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s

Q: 500   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDARTNTFCGTPDYIAPEILLGQKYNHS  559

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe

Q: 560   VDWWTFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  619

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  di+eh++f

Q: 620   KRLGV--RG--DIREHPLF  634

         *****..55..89999987

Domain Sequence
(FASTA)

FILHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60

FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQICHKFDLC RATFYAAEII LGLQFLHSKG 120

IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDARTNTF CGTPDYIAPE ILLGQKYNHS 180

VDWWTFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240

KRLGVRGDIR EHPLF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0001772	; C:immunological synapse
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction
GO:0006509	; P:membrane protein ectodomain proteolysis
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0070233	; P:negative regulation of T cell apoptotic process
GO:0032740	; P:positive regulation of interleukin-17 production
GO:0045086	; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753	; P:positive regulation of interleukin-4 production
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102	; P:positive regulation of T cell proliferation
GO:2000318	; P:positive regulation of T-helper 17 type immune response
GO:2000570	; P:positive regulation of T-helper 2 cell activation
GO:0090330	; P:regulation of platelet aggregation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013