EPS-LOA-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.0	2.0E-56	78	331	254

Status

Unreviewed

Ensembl Protein

ENSLAFP00000002826

UniProt Accession

G3SSA8;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000003394	ENSLAFP00000002826	ENSLAFT00000003396

Organism

Loxodonta africana

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

NCPSFLAAAL ARATSDEVLQ SDLSAHYIPK ETDGTEGTVE IETVKLARSV FSKLHEICCS 60

WVKDFPLRRR PQLYYETSIH AIKNMRRKME DKHVCIPDFN MLFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNLVRQ EMFPHDPAEA LCRAFRVTDE RFVQKAARES LRCGTTGVVT 180

FIRGNMLHVA WVGDSQVMLV RKGQAVELMK PHKPDREDEK QRIEALGGCV VWFGAWRVNG 240

SLSVSRAIGD AEHKPYICGD ADSASTVLDG TEDYLILACD GFYDTVNPDE AVKVVSDHLK 300

ENNGDSSMVA HKLVASARDA GSSDNITVIV VFLRDMNKAV NVSEESDWTE NSFQGGQEDG 360

GDDKENHGEC KRPWPQHQCS APADLGYDGR VDSFTDRTSL SPGSPINVLE DPGYLDLTQI 420

EANKPHSAQF LPPVEMFGPG APKKANFINE LMMEKISVQS SLPEWSGSGE LPASFNLGST 480

GQHIHKMESP SPVCSRSENE QFKSLGKTVS RLSHLRHHYS KRRHGFRLNA KFYSFLSAQE 540

LSHKTGTSLS SLIRSGKRSR MLRSSLPWKQ NSWKGYSESM VKLRESDGTP YSDLPWSYKM 600

Nucleotide Sequence
(FASTA)

AATTGCCCGT CCTTTTTGGC TGCTGCTTTA GCCAGAGCCA CATCAGATGA AGTCCTTCAG 60

AGTGATCTTT CTGCACATTA TATACCAAAG GAAACGGACG GCACAGAAGG GACTGTGGAG 120

ATCGAGACGG TGAAATTGGC CCGTTCTGTC TTCAGCAAAC TACACGAGAT TTGCTGCAGC 180

TGGGTGAAAG ACTTCCCTCT CCGCAGAAGA CCCCAGCTCT ATTATGAGAC ATCAATTCAC 240

GCCATCAAAA ACATGCGCAG GAAAATGGAG GACAAACATG TCTGCATTCC TGACTTTAAT 300

ATGCTCTTCA ACCTAGAGGA CCAAGAAGAA CAAGCTTACT TTGCAGTGTT TGATGGCCAT 360

GGTGGAGTGG ATGCTGCTAT CTATGCCTCC ATTCACCTCC ATGTTAATTT GGTCCGTCAA 420

GAAATGTTCC CCCATGATCC TGCTGAGGCC TTGTGCCGGG CCTTCCGGGT CACTGATGAG 480

CGGTTTGTGC AGAAAGCAGC CAGGGAGAGC TTAAGATGTG GGACCACAGG AGTGGTGACT 540

TTTATCAGAG GCAACATGCT GCACGTGGCC TGGGTGGGTG ATTCTCAGGT TATGCTTGTG 600

AGAAAGGGCC AAGCTGTTGA ACTAATGAAG CCACACAAAC CAGACAGAGA GGATGAAAAG 660

CAGCGAATTG AGGCCCTTGG AGGTTGCGTA GTCTGGTTTG GTGCCTGGAG GGTGAATGGA 720

AGTCTGTCGG TCTCCAGAGC TATTGGAGAT GCTGAACATA AGCCATATAT CTGTGGAGAC 780

GCAGACTCTG CCTCTACTGT CTTGGATGGG ACTGAAGACT ACCTCATTCT GGCCTGTGAT 840

GGCTTCTATG ACACTGTGAA CCCAGATGAG GCGGTGAAAG TTGTGTCTGA CCACTTGAAG 900

GAGAATAACG GAGACAGCAG CATGGTTGCC CATAAATTAG TGGCATCAGC TCGTGATGCT 960

GGGTCCAGTG ATAACATCAC TGTTATTGTG GTATTCCTGA GGGACATGAA CAAGGCTGTA 1020

AATGTTAGTG AGGAATCAGA TTGGACAGAG AACTCTTTTC AAGGAGGGCA AGAAGATGGT 1080

GGGGATGATA AGGAGAATCA TGGAGAGTGC AAACGCCCTT GGCCTCAGCA CCAGTGCTCA 1140

GCACCAGCCG ATCTAGGCTA TGATGGGCGT GTGGATTCAT TTACTGATAG AACTAGCCTG 1200

AGCCCAGGGT CCCCAATCAA CGTGCTGGAA GACCCAGGTT ACTTAGATCT CACCCAGATA 1260

GAAGCAAATA AACCTCACAG TGCCCAGTTT TTACCACCAG TTGAGATGTT TGGTCCTGGT 1320

GCACCAAAGA AAGCAAATTT TATTAATGAG TTAATGATGG AGAAAATATC AGTTCAATCA 1380

TCATTGCCTG AATGGAGTGG TTCTGGAGAG CTTCCCGCTT CTTTTAATTT AGGTTCAACA 1440

GGGCAGCATA TACACAAAAT GGAGAGCCCG TCTCCTGTCT GTTCTAGGTC GGAAAACGAA 1500

CAGTTCAAAT CCCTGGGAAA GACAGTTTCT AGACTGTCTC ATTTACGCCA CCATTACTCA 1560

AAGAGGCGGC ACGGATTCAG GCTTAATGCA AAGTTTTATT CATTTCTCTC TGCTCAGGAG 1620

CTTTCCCACA AAACAGGCAC TAGCCTGTCC TCACTTATTC GAAGTGGGAA GAGAAGTAGG 1680

ATGTTAAGAA GTTCTTTGCC ATGGAAGCAA AACAGTTGGA AAGGATACAG TGAGAGCATG 1740

GTGAAGCTCA GAGAGAGCGA TGGTACTCCA TATTCAGATC TTCCCTGGAG CTATAAAATG 1800

TAA 1803

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 78    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  137

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 138   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  191

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 192   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  250

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 251   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  310

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 311   HKLVASARDAGSSDNITVIVV  331

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013