EKS-LOA-00442

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00442

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	355.5	2.5E-106	18	285	268

Status

Unreviewed

Ensembl Protein

ENSLAFP00000002919

UniProt Accession

G3SSI6;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1

Gene Synonyms/Alias

ULK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000003503	ENSLAFP00000002919	ENSLAFT00000003504

Organism

Loxodonta africana

Functional Description

Protein Length

1056

Protein Sequence
(FASTA)

REGRGGVRGH GDLVLSFPAK DLIGQGGFEV VIKERHREKH DLEVAVKCIN KKNLAKSQTL 60

LGKEIKILKE LKHENIVALY DFQEMANSVY LVMEYCNGGD LADYLHTMRT LSEDTIRLFL 120

QQIAGAMRLL HSKDIIHRDL KPQNILLSNP GRRANPNNIR VKIADFGFAR YLQSNMMAAT 180

LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQAFSRASVR LGSWARLPAN 240

PALLTPAPSI PRETSAPLRQ LLLALLQRNH KDRMDFDEFF HHPFLDASAS IKKSPPVPVP 300

SYPSSGSGSS SSSSSTSHLA SPPSLGEIQQ LQKTLTSPAD AAAFLQGSRD SGGSSKDSSC 360

DTDDFVMVPA QFPGDLGAEA ASAKPLPDSL LCSGSSLVAS AGLESHGRTP SPSPPYSGSP 420

SPSGRAGPSS SRYGVSVPIP VPTQVHNYQR IEQNLQLPAQ YMAPRSTAIR RSDSTSPLGF 480

TRASPSPPSH AEHGAALARR FSLGGARPYT PSPQVGTIPE GPGLSGAPSP QGAETRGGKF 540

PRPGSSVPEH SPRAAGLGCR LHSAPNLSDL HVVCPKLPKP PTDPLGTAFG PPQASPPLSA 600

CRPLRGSPKL PDFLQRSPLP PILGSPTKAS PSFDFPKTPS SQNLLALLAR QGVMVAPPRN 660

RTLPDLTDGG PYQAQPLGPG LRPPEEAKGP FGRSLSTGRL TDLLLKAAFG TQAPDSGSTD 720

SLQEKPMEIA PSTGFGGNLH SGARAGGASS PSPVVFTVGS PPSGTTPPQG PRTRMFSVGS 780

SGSLSSAGSS SGRHLLPGAC NEAAAPEPPA PGHCYSYVDP IAANLEGVVT FEAPDLPEET 840

LMEQEHTETL HGLRFTLAFV QHVLEIAALK GSAGEVAGSP DYQLQESLVA DQISLLSREW 900

SFAEQLVLYL KVAELLSAGL QTAIDQIRAG KLCLSSTVKQ VVRKLNELYK SSVVSCQDLS 960

LRLQRFFLDK QRLMDRVHSI TAERLIFSHA VQTVQSAALD EMFHRREDCV QRYHKALLLM 1020

EGLQQILVDQ ADVENIAKCK LCIERRLSAL LTGLCA 1056

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 2     sleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheniv  61

          +++ iG+G f vv k r+r+k++ +vA+k+++kk+l+ks++ l keikilkelkheniv

Q: 18    PAKDLIGQGGFEVVIKERHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIV  77

         5789********************************************************

S: 62    alldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkivh  121

         al+d++e++++vylvmeyc+ggdLa++l+++++Lsedt+r flqq+a a+++Lhsk+i+h

Q: 78    ALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKDIIH  137

         ************************************************************

S: 122   rDlkPqniLlsyadakkelkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqq  181

         rDlkPqniLls+  ++ + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++q+

Q: 138   RDLKPQNILLSNPGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQH  197

         ***********999999*******************************************

S: 182   ydakaDlWSiGtilyellvGkpPfaaesiseLv..eki..ekndvl.epp..ipkeisse  234

         yd kaDlWSiGti+y++l+Gk+Pf+a s   ++  +     +n++l +p   ip+e+s+

Q: 198   YDGKADLWSIGTIVYQCLTGKAPFQAFSRASVRlgSWArlPANPALlTPApsIPRETSAP  257

         ************************9988766541143323678665233244999*****

S: 235   lkdllqsLLqrdpkkRisfeelfahpfl  262

         l++ll +LLqr++k+R++f+e+f+hpfl

Q: 258   LRQLLLALLQRNHKDRMDFDEFFHHPFL  285

         **************************96

Domain Sequence
(FASTA)

PAKDLIGQGG FEVVIKERHR EKHDLEVAVK CINKKNLAKS QTLLGKEIKI LKELKHENIV 60

ALYDFQEMAN SVYLVMEYCN GGDLADYLHT MRTLSEDTIR LFLQQIAGAM RLLHSKDIIH 120

RDLKPQNILL SNPGRRANPN NIRVKIADFG FARYLQSNMM AATLCGSPMY MAPEVIMSQH 180

YDGKADLWSI GTIVYQCLTG KAPFQAFSRA SVRLGSWARL PANPALLTPA PSIPRETSAP 240

LRQLLLALLQ RNHKDRMDFD EFFHHPFL 268

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005776	; C:autophagic vacuole
GO:0030659	; C:cytoplasmic vesicle membrane
GO:0005829	; C:cytosol
GO:0043005	; C:neuron projection
GO:0043025	; C:neuronal cell body
GO:0034045	; C:pre-autophagosomal structure membrane
GO:0070969	; C:ULK1-ATG13-FIP200 complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000045	; P:autophagic vacuole assembly
GO:0048675	; P:axon extension
GO:0021707	; P:cerebellar granule cell differentiation
GO:0048671	; P:negative regulation of collateral sprouting
GO:0016239	; P:positive regulation of macroautophagy
GO:0046777	; P:protein autophosphorylation
GO:0008104	; P:protein localization
GO:0021933	; P:radial glia guided migration of cerebellar granule cell
GO:0007265	; P:Ras protein signal transduction
GO:0031623	; P:receptor internalization
GO:0051386	; P:regulation of nerve growth factor receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013