EKS-LOA-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec447.41.5E-134371605235
StatusUnreviewed
Ensembl ProteinENSLAFP00000025200
UniProt AccessionG3UBJ2;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000003582ENSLAFP00000002987ENSLAFT00000003581
ENSLAFG00000003582ENSLAFP00000025200ENSLAFT00000027907
OrganismLoxodonta africana
Functional Description
Protein Length605
Protein Sequence
(FASTA)
VSFHYAAKEI TQQGSNNKKM EKEAPQNFPV LNREYFAHAY KGYGKKRTLK GSIELSRIKC 60
VEIVRSDISI PCHYKYPFQV VHDNYLLYVF APDRESRQRW VLALKEETRN NNSLVSKYHP 120
NFWIDGRWRC CAQLEKLAVG CAEYDPTKNA SKKPLPPTPE DNRRYLPPSA EPMDENKEPE 180
ETLVIALYDY QTNDPQELTL RRNEEYYLLD SSEIHWWRVQ DRNGHEGYVP SSYLVEKSPN 240
NLETYEWYNK SINRDKAEKL LLDTGKEGAF MVRDSRTPGT YTVSVFTKAV VSENNPCIKH 300
YHIKETNDNP KRYYVAEKYV FDSIPLLINY HQHNGGGLVT RLRYPVCSWR QKAPVTAGLR 360
YGKWVIDPSE LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEIMMK 420
LSHPKLVQLY GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG VFAAETLLGM CLDVCEGMAY 480
LEDACVIHRD LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF 540
SRYSSKSDVW SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASTNVYQIMN 600
HCWKE 605
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea++mmklshpklvqly
Q: 371   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEIMMKLSHPKLVQLY  430
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle +++ihrd
Q: 431   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGVFAAETLLGMCLDVCEGMAYLEDACVIHRD  490
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 491   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  550
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwke  235
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m++cwke
Q: 551   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTNVYQIMNHCWKE  605
         *****************************************************97
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEIMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG VFAAETLLGM CLDVCEGMAY LEDACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASTNVYQIMN HCWKE 235
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0035556; P:intracellular signal transduction
GO:0001865; P:NK T cell differentiation
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR013315; Spectrin_alpha_SH3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR01887; SPECTRNALPHA.
PR00109; TYRKINASE.
Created Date20-Feb-2013