EKS-LOA-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	348.9	2.5E-104	879	1151	273

Status

Unreviewed

Ensembl Protein

ENSLAFP00000021176

UniProt Accession

G3U018;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000003730	ENSLAFP00000003110	ENSLAFT00000003730
ENSLAFG00000003730	ENSLAFP00000021176	ENSLAFT00000029243

Organism

Loxodonta africana

Functional Description

Protein Length

1158

Protein Sequence
(FASTA)

LQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLPDREPLRL SSGEYTAEDL 60

CIKAAQECCI SPLCHNLFAL YDENTKLWYA PNRTITVDDK TSLRLHYRMR YGFYFTNWHG 120

TNDSEHSLWS LLGKSQVTEL AFETRHVNLC LPLLKAESPE VVFVQGQYDL VKCLAPIRDP 180

KTEQDGHDIE NECLGMAVLA ISHYAMMKKM QLPELPKDIS YKRYIPETLN KSIRQRNLLT 240

RMRINNVFKD FLKEFNNKTI CDSSVSTHDL KVKYLATLET LTKHYGAEIF ETSMLLISSE 300

NEMNRFHSND SGNILYYEVM VTGNLGIQWR QKPNVLPVEK EKNKLKRKKL ENKHKKDEEK 360

NKIREEWNNF SYFPEITHIV IKESVVSINK QDNKKMELKL SSHEEALSFV SLVDGYFRLT 420

ADAHHYLCTD VAPPLIVHNI ENGCHGPICT EYAINKLRQE GSEEGMYVLR WSCTDFDNIL 480

MTVTCFEKTE QVLGGQKQFK NFQIEVQKGH YSLHGSDRSF PTLGELMGHL KKQILRTDNI 540

SFVLKRCCQP KPREISNLLV ATKKAQEWQP VYTMSQLSFD RILKKDIMQG EHLGRGTRTH 600

IYSGTLMDYK DDEGTSEEKR IKVILKVLDP SHRDISLAFF EAASMMRQVS HKHIVYLYGV 660

CVRDVENIMV EEFVEGGPLD LFMHRRSDAL TTPWKFKVAK QLASALSYLE DKDLVHGNVC 720

TKNLLLAREG IDSECGPFIK LSDPGIPITV LTRQECIERI PWIAPECVED SKNLSVAADK 780

WSFGTTLWEI CYNGEIPLKD KTLIEKERFY ESRCRPVTPS CKELADLMTH CMNYDPNQRP 840

FFRAIMRDIN KLEEQNPDIV SERKPATEVD PTHFEKRFLK RIRDLGEGHF GKVELCRYDP 900

EGDNTGEQVA VKSLKPESGG NHIADLKKEI EILRNLYHEN IVKYKGICTE DGGNGIKLIM 960

EFLPSGSLKE YLPKNKNKIN LKQQLKYAVQ ICKGMDYLGS RQYVHRDLAA RNVLVESEHQ 1020

VKIGDFGLTK AIETDKEYYT VKDDRDSPVF WYAPECLIQC KFYIASDVWS FGVTLHELLT 1080

YCDSDSSPMA LFLKMIGPTH GQMTVTRLVN TLKEGKRLPC PPNCPDEVYH LMRKCWEFQP 1140

SNRTTFQNLI EGFEALLK 1158

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 879   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  938

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 939   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  998

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 999   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1052

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1053  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1111

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +ps+r++F++++e

Q: 1112  LKEGKRLPCPPnCPDEVYHLMRKCWEFQPSNRTTFQNLIE  1151

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YHLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013