EKS-LOA-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	395.2	2.0E-118	269	562	294

Status

Unreviewed

Ensembl Protein

ENSLAFP00000003159

UniProt Accession

G3ST25;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000003785	ENSLAFP00000003159	ENSLAFT00000003784
ENSLAFG00000003785	ENSLAFP00000027212	ENSLAFT00000029861

Organism

Loxodonta africana

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

MGRGLLGGLW PLHIVLWTRI ASTIPPHVQK PGKFRFLWFV FSIHLTCPKL KKNLNAFNDD 60

MMVTDDNGAL KLRQLCKFCD VRFSTCDNQK SCMSNCSITS ICEKPHEVCV AVWRKNDENI 120

TLETVCHDPT IAYHGFVLDD ATSSKCIMKE KKTPGETFFM CSCSAEECND HIIFSEEYNT 180

SSPDLLLVII QVTGVSLLPP LGIAIAVIIT FYCYRVHRQQ KLSPSWETSK PRKLMEFSEH 240

CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300

VKIFPYEEYA SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360

YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420

CDFGLSLHLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480

EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDNVLRDR GRPEIPSSWL NHQGIQMVCE 540

TLTECWDHDP EARLTAQCVA ERFSELEHLD RLSGRSCSEE KIPEDGSLNT TK 592

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 269   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  328

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 329   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  388

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 389   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLHLDPTLSVDDLANSGQVGTA  447

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 448   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  506

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 507   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  562

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLH LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013