EKS-LOA-00031
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00031
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak324.95.4E-978791149271
StatusUnreviewed
Ensembl ProteinENSLAFP00000003280
UniProt AccessionG3STB4;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000003922ENSLAFP00000003280ENSLAFT00000003924
OrganismLoxodonta africana
Functional Description
Protein Length1169
Protein Sequence
(FASTA)
TVQSMPLCRW GATARGSKPD GNGAQPMVSR GVLRVHLHWA GPGGGEPWVT FSEASLTAEE 60
VCIYIAHKIG ITPLCFNLFA LFDAQGQVWL PPNHILEVPR DSSLNLHFRM RFYFRNWHGM 120
NPQEPAVYRC GPPGAESSSD QAEHGLQFLD PASFEYIFEQ GKHEFVNDVA SLWELSSEEE 180
IHHFKNESLG MAFLHLCHLA LHRGVSLEEV AKKISFKDCI PRSFRSQIQQ HNALTRLRLR 240
SIFHKFLRAF QPSHLSQQLV MVKYLATLER LAPCFATEHI PVCHLELPAQ AEGKLCYIQD 300
HGQATLDPGK ESALGPPTHE VLVTGTGGIQ WRPVQAEGSG GSGSGSRNPQ ANLSGKKAQA 360
QEVDLQPASR PKGLPWASFC DFQDISHLVV KEHHVSVYCQ DNKCLELTLP SRATALSFVS 420
LVDGYFRLTV DSSHYLCHEV APPRLVMSIQ DGIHGPLLDP FVLAKLQPED GHYLIHWSSS 480
HLYRLILTVA QRDQAQGSRS LRLRKFTIEQ QAGTFTLEGW DRSFPSVGAL RAALQDCSLR 540
VGDDCFSLRR CCLPLSRELS NLIIMRGPAA STRPLNLSQL SFHRVCREEI TQLSHLGQGT 600
RTNVYEGLLR VKGRDSEEDK EEGGDPLSPS RGSGQELRVV LKVLDPSHHD ITLAFYEIAS 660
LMSQVSHVHL AFVHGICVHG SESECPLPLL IGQLPLIPSP WPVVAIPEPL TCTPYPGYTP 720
TLNLRPFPWL HLNSQIRPQL LTTPPQASLY PDPTPWLHHE CLHLPPKTLY NPAPIFPLTS 780
LALTLCDTAL TSALQFNPAQ SPLYLYPYCV SLKIPVLSTP SPASITSYEC LTYEPAQRPS 840
FRIILRDLTR LQPHNLVDVS AVSPDLPASD PTVFHKRYLK KIRELGEGHF GKVSLYCYDP 900
TNDGTGEMVA VKSLKAGCGP QLRSGWKREI DILRRLYHEH IVKYKGCCED PGEKSVQLVM 960
EYVPLGSLRD YLPRHSVGLA QLLLFAQQIC EGMAYLHAQH YIHRDLAARN VLLDNDRLVK 1020
IGDFGLAKAV PEGHEYYRVR EDGDSPVFWY APECLKECKF YYASDVWSFG VTLYELLTRC 1080
DFSQSPPLKF IELLGLTQGQ MTVLRLTELL ERGERLPRPE ACPCEIYYLM KNCWEAEASF 1140
RPTFQNLIPI LKTVHEKYQG QAPSVFSMC 1169
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk  +g++ ++++kre++il+ l+h
Q: 879   LKKIRELGEGHFGKVSLYCYDPTNDGTGEMVAVKSLKaGCGPQLRSGWKREIDILRRLYH  938
         6899*********************************99*********************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL
Q: 939   EHIVKYKGCCEDPGEKsvQLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  996
         ****************9********************..*********************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+
Q: 997   HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1050
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219
         apecl+e+k +++asdvWsFgvtlyellt c+ ++sp         l     +       
Q: 1051  APECLKECK-FYYASDVWSFGVTLYELLTrCDFSQSPplkfiellgL-----Tqgqmtvl  1104
         *********.****************************777444443.....25666699
S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         r++elle++erlp+p+ cp+e++ lm+nc+++e+s+rp+F++++ 
Q: 1105  RLTELLERGERLPRPEaCPCEIYYLMKNCWEAEASFRPTFQNLIP  1149
         *****************************************9975
Domain Sequence
(FASTA)
LKKIRELGEG HFGKVSLYCY DPTNDGTGEM VAVKSLKAGC GPQLRSGWKR EIDILRRLYH 60
EHIVKYKGCC EDPGEKSVQL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120
QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180
KFYYASDVWS FGVTLYELLT RCDFSQSPPL KFIELLGLTQ GQMTVLRLTE LLERGERLPR 240
PEACPCEIYY LMKNCWEAEA SFRPTFQNLI P 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00028
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-FEC-00030
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-MAM-00032
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORA-00027
EKS-ORC-00032
EKS-OTG-00034
EKS-PAT-00030
EKS-POA-00029
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-XET-00032
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013