EKS-LOA-00275
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00275
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK470.53.4E-141205518314
StatusUnreviewed
Ensembl ProteinENSLAFP00000024369
UniProt AccessionG3U961;
Protein Name
Protein Synonyms/Alias
Gene NameDYRK2
Gene Synonyms/Alias DYRK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000004507ENSLAFP00000024369ENSLAFT00000004506
OrganismLoxodonta africana
Functional Description
Protein Length584
Protein Sequence
(FASTA)
GRGGDIAVRQ LQVSPGLGAG APRSGVGTGP PSPIALPPLR ASNAAAAAHT IGGSKHTMND 60
HLHVSSHSHG QIQVQQLFED NSNKRTVLTT QPNGLTVGKT GLPVVPERQL ENIHRRQGSS 120
TSLKSMEGLG KVKATPMTPE QAMKQYMQKL TTFEHHEIFS YPEIYFLGPN AKKRQGMTGG 180
PNNGGYDDDQ GSYVQVPHDH VAYRYEVLKV IGKGSFGQVV KAYDHKVHQH VALKMVRNEK 240
RFHRQAAEEI RILEHLRKQD KDNTMNVIHM LENFTFRNHI CMTFELLSMN LYELIKKNKF 300
QGFSLPLVRK FAHSILQCLD ALHKNRIIHC DLKPENILLK QQGRSGIKVI DFGSSCYEHQ 360
RVYTYIQSRF YRAPEVILGA RYGMPIDMWS LGCILAELLT GYPLLPGEDE GDQLACMIEL 420
LGMPSQKLLD TSKRAKNFVS SKGYPRYCSV TTLSDGSVVL NGGRSRRGKL RGPPESREWG 480
NALKGCDDPL FLDFLKQCLE WDPVVRMTPG QALRHPWLRR RLPKPPTGEK TAVKRITEST 540
GAITSISKLP PPSSSASKLR TNLAQMTDAN GNIQQRTVLP KLVS 584
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++
Q: 205   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  264
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++
Q: 265   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  324
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180
         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y 
Q: 325   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  383
         *************************************.**********************
S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240
         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+
Q: 384   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDTSKRAKNFVSSKG  443
         ************************************************************
S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300
         +p+y+ +t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp
Q: 444   YPRYCSVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  503
         ************************************************************
S: 301   akRitpkealkhpfv  315
           R+tp +al+hp++
Q: 504   VVRMTPGQALRHPWL  518
         **************6
Domain Sequence
(FASTA)
YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60
MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120
NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180
PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDTSKR AKNFVSSKGY 240
PRYCSVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPV 300
VRMTPGQALR HPWL 314
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00254
EKS-BOT-00265
EKS-CAE-00237
EKS-CAJ-00271
EKS-CAF-00272
EKS-CAP-00300
EKS-CHH-00017
EKS-CII-00159
EKS-CIS-00039
EKS-DAR-00600
EKS-DAN-00013
EKS-DRM-00136
EKS-ECT-00027
EKS-EQC-00257
EKS-ERE-00019
EKS-FEC-00251
EKS-GAM-00163
EKS-GAG-00222
EKS-GAA-00325
EKS-GOG-00265
EKS-HOS-00271
EKS-ICT-00250
EKS-LAC-00277
EKS-MAM-00267
EKS-MEG-00210
EKS-MUM-00296
EKS-MUP-00262
EKS-MYL-00267
EKS-NOL-00243
EKS-OCP-00023
EKS-ORN-00342
EKS-ORA-00232
EKS-ORC-00250
EKS-ORL-00319
EKS-OTG-00271
EKS-PAT-00250
EKS-PES-00235
EKS-PEM-00140
EKS-POA-00258
EKS-PTV-00034
EKS-RAN-00280
EKS-SAH-00249
EKS-SOA-00021
EKS-SUS-00230
EKS-TAG-00280
EKS-TAR-00338
EKS-TEN-00333
EKS-TUB-00020
EKS-TUT-00030
EKS-XET-00340
EKS-XIM-00334
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0030529; C:ribonucleoprotein complex
GO:0000151; C:ubiquitin ligase complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013