EPS-LOA-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	169.2	1.8E-49	314	501	188

Status

Unreviewed

Ensembl Protein

ENSLAFP00000004702

UniProt Accession

G3SWJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000005600	ENSLAFP00000028847	ENSLAFT00000025323
ENSLAFG00000005600	ENSLAFP00000004702	ENSLAFT00000005601

Organism

Loxodonta africana

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGIGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD NETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGAGTGEE 180

QWSQGLNGET GPEDPSRETP SEENGPTAKA HTGLSSNSER GTEAGQVGEP GTPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDDEEEEE MMVPGMEGKE EPGSDSGTTA VVALIRGKQL IVANAGDSRC VVSEAGKALD 360

MSYDHKPEDE VELARIKNAG GKVTMDGRVN GGLNLSRAIG DHFYKRNKNL PPEEQMISAL 420

PDIKVLTLTD DHEFMVIACD GIWNVMSSQE VVDFIQSKIS QRDENGELRL LSSIVEELLD 480

QCLAPDTSGD GTGCDNMTCI IICFKPRNIA ELQPESGKRK LQEVLTSEGA EENGNSGNKK 540

AKRD 544

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCCCA GCCCAACACA GTGAAGTGCT CCGGAGACGG GATCGGCGCC 60

CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGAGT TTCCATGGAG 120

GATGCCCACA ACTGTATTCC TGAGCTGGAC AATGAGACAG CAATGTTTTC TGTCTACGAT 180

GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GATCAGAAGG CCTACAAGGA AGGCAAACTA CAGAAGGCTT TGGAAGATGC CTTCTTGGCT 300

ATTGATGCCA AACTGACCAC CGAGGAAGTC ATTAAGGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ACGAGGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CAATGGTCCC AGGGCCTCAA TGGGGAGACA GGACCTGAGG ACCCATCTAG GGAAACTCCT 600

TCAGAGGAAA ATGGCCCCAC AGCTAAGGCC CACACAGGCC TTTCCTCCAA CTCAGAACGT 660

GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCACTCCCA CTGGTGAGGC TGGGCCCTCC 720

TGCTCCTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAGGAA GAGGAAGACA GTGAGGAATG CAGTGAGGAA 840

GAGGATGGCT ATAGCAGTGA GGAGGCAGAG AATGAAGAAG ATGAGGATGA CACTGAGGAG 900

GCAGAAGAGG ACGATGAAGA AGAAGAAGAG ATGATGGTGC CTGGGATGGA AGGCAAAGAG 960

GAGCCTGGCT CTGACAGTGG CACAACAGCG GTGGTAGCTC TGATACGAGG GAAGCAGTTG 1020

ATTGTAGCCA ATGCAGGAGA CTCTCGCTGT GTGGTGTCTG AGGCTGGCAA AGCTTTAGAC 1080

ATGTCCTATG ACCACAAACC AGAGGATGAA GTGGAGCTAG CTCGCATCAA GAATGCTGGT 1140

GGCAAGGTCA CCATGGATGG GCGAGTCAAC GGGGGCCTCA ACCTCTCCAG AGCCATTGGT 1200

GACCACTTCT ACAAGAGAAA CAAGAACCTT CCCCCTGAGG AACAGATGAT TTCAGCTCTT 1260

CCTGACATCA AGGTGCTGAC GCTCACTGAT GACCACGAAT TCATGGTCAT TGCCTGTGAT 1320

GGCATTTGGA ATGTGATGAG CAGTCAGGAA GTTGTAGACT TTATTCAGTC AAAGATCAGC 1380

CAGCGAGATG AAAATGGGGA GCTTCGGTTA CTGTCATCCA TTGTGGAAGA GCTATTGGAT 1440

CAGTGCCTGG CACCTGACAC TTCTGGGGAT GGTACAGGGT GTGACAACAT GACCTGCATC 1500

ATCATTTGCT TCAAGCCCCG AAACATAGCC GAGCTCCAGC CAGAGAGTGG CAAGCGGAAA 1560

CTGCAGGAGG TGCTCACCTC TGAGGGGGCA GAGGAAAATG GCAACAGCGG CAACAAGAAG 1620

GCCAAGCGGG AC 1632

Domain Profile

S: 91    kvleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkpsredEl  150

           +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp+ e El

Q: 314   PGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVEL  373

         334444455566************************************************

S: 151   eRieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevtshrltse  201

         +Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ + +lt +

Q: 374   ARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDD  431

         *************9..********************************************

S: 202   defliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalargsk...  252

         +ef+++a+DG+w+v+s++e+v+++++ ++      + + ++++ ++L++++la  ++

Q: 432   HEFMVIACDGIWNVMSSQEVVDFIQSKISqrdengELRLLSSIVEELLDQCLAPDTSgdg  491

         **************************9998877666667788999999999999998777

S: 253   ...dnvsaiv  259

            dn++ i+

Q: 492   tgcDNMTCII  501

7777777766

Domain Sequence
(FASTA)

PGMEGKEEPG SDSGTTAVVA LIRGKQLIVA NAGDSRCVVS EAGKALDMSY DHKPEDEVEL 60

ARIKNAGGKV TMDGRVNGGL NLSRAIGDHF YKRNKNLPPE EQMISALPDI KVLTLTDDHE 120

FMVIACDGIW NVMSSQEVVD FIQSKISQRD ENGELRLLSS IVEELLDQCL APDTSGDGTG 180

CDNMTCII 188

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013