EKS-LOA-00354

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00354

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	414.6	1.9E-124	128	382	255

Status

Unreviewed

Ensembl Protein

ENSLAFP00000028845

UniProt Accession

G3UK03;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000005804	ENSLAFP00000028162	ENSLAFT00000032421
ENSLAFG00000005804	ENSLAFP00000028845	ENSLAFT00000025706
ENSLAFG00000005804	ENSLAFP00000004866	ENSLAFT00000005805

Organism

Loxodonta africana

Functional Description

Protein Length

1028

Protein Sequence
(FASTA)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKAIG ARVCWVRQVF SGKRLETEFP PDHSQSAFRK TSPTPGGPAG EGLQSLTCLI 120

GEKDLHLFEK LGDAPLPWTQ SEWDAPSEKT VSVAVKCLKP DVLSQPEAMD DFIREVNAMH 180

SLDHRNLIRL YGVVLTPPMK MVTELAPLGS LLDRLRKHQG HFWGLLSRYA VQVAEGMGYL 240

ESKRFIHRDL AARNLLLATR DLVKIGDFGL MRALPQNDDH YVMQEHRKVP FAWCAPESLK 300

TRTFSHASDT WMFGVTLWEM FTYGQEPWIG LNGSQILHKI DKEGERLPRP EDCPQDIYNV 360

MVQCWAHKPE DRPTFVALRD FLLEAQPTDM RALQDFEEPD KLHIQMNDVI TVIEGRAENY 420

WWRGQNTRTL CVGPFPRNVV TSVAGLSAQD ISQPLQNSFI HTGHGDSDPR HCWGFPDKID 480

ELYLGNPMDP PDLLSVELST SQPTQHLGRV KREPPPRPPQ PAIFTQKPTY DPVSEDQDLL 540

SSDFKRLGLR KPGLPRGLWL AKPSARVPGT KAGRSSGGEV TLIDFGEEPV APAPRPCTPS 600

LAQLAMDACS LLDKTPPQSP TRALPRPLHP TPVVDWDARP LPPPPVYDDV AQDEDDFEVC 660

SINSTLVGTG GPAGPSQGET NYAFVPEQAR LLMPLEDNLF LPAQGEGKSP NSAQTAEIFQ 720

ALQQECMRQL QAPAGSLAPS PSPLGDDKPQ VPPRVPIPPR PTRPRGELSP VPSGEEEMGR 780

WPESASPPRV PPREPLSPQG SRTPSPLVPP GSSPLSLRLS SSPGKAMPTT QSFASDPKYA 840

TPQVIQAPGP RAGPCILPIV RDGKKVSNTH YYLLPERPSY LERYQRFLRE AQSPEEPVRP 900

MPQAAPDPKA NFSTNNSNPG VRPPSLRAAA QLLQRGCPGD GSEAGRPTDK VQMLQAMVHG 960

VTTEECQAAL QSHGWSVQRA AQYLKVEQLF GLGLRPRGEC HKVLEMFDWN LEQAGCHLLG 1020

SCGPAHHK 1028

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 4     leklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllklehen  62

          eklG+  +    ++eW+aps+k+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h+n

Q: 128   FEKLGDAPLPW-TQSEWDAPSEKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDHRN  186

         66777776654.589**************************99*****************

S: 63    lvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglaylesk  122

         l+rlyGvvlt p+k+vtela+lgslldrlrk++   +    ll++yavq+aeg+ ylesk

Q: 187   LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--H-FWGLLSRYAVQVAEGMGYLESK  243

         *********************************9..4.5799******************

S: 123   rlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtrk  182

         r++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+tr+

Q: 244   RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT  303

         ************************************************************

S: 183   fssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslllk  242

         fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++++

Q: 304   FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQ  363

         ************************************************************

S: 243   cWakkpadrpkfsalkekl  261

         cWa+kp+drp+f+al+++l

Q: 364   CWAHKPEDRPTFVALRDFL  382

         ****************986

Domain Sequence
(FASTA)

FEKLGDAPLP WTQSEWDAPS EKTVSVAVKC LKPDVLSQPE AMDDFIREVN AMHSLDHRNL 60

IRLYGVVLTP PMKMVTELAP LGSLLDRLRK HQGHFWGLLS RYAVQVAEGM GYLESKRFIH 120

RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE SLKTRTFSHA 180

SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI YNVMVQCWAH 240

KPEDRPTFVA LRDFL 255

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0030136	; C:clathrin-coated vesicle
GO:0005905	; C:coated pit
GO:0030425	; C:dendrite
GO:0070436	; C:Grb2-EGFR complex
GO:0030426	; C:growth cone
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0050731	; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369	; P:regulation of clathrin-mediated endocytosis

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.
SM00165	; UBA; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013