EKS-LOA-00400

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00400

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	335.4	3.5E-100	651	906	256

Status

Unreviewed

Ensembl Protein

ENSLAFP00000005073

UniProt Accession

G3SXE6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000006042	ENSLAFP00000005073	ENSLAFT00000006045
ENSLAFG00000006042	ENSLAFP00000022266	ENSLAFT00000035555

Organism

Loxodonta africana

Functional Description

Protein Length

1279

Protein Sequence
(FASTA)

MAGTCSRSAA LERAGSCWQD PLAEALSRGR APAASSGRGC ARSRPLSVVY VLTREQRPAA 60

ETGAGAEAEP LPLRCLRDAC AQLQGPRPSP QLRSLPFGTL ALGDTAALDS FYNADVVVLE 120

VSSSLVQPSL FYHLGVRESF SMTNNVLLCS QADLPDLQAL RDDVFQKNSD CVGSYTLIPY 180

VVTATGRVLC GDAGVLRGLA DGLVQAGVGT EALLTPLVGR LVRLLEATPT DSCGYFRETI 240

RQDIRRARER FSGQQLRQEL ARLQRGLDSV ELLSPDIVMN LLLSYRDVQD YSAIIELVET 300

LQALPTCDVA EQHNVCFHYT FALNRRNRPG DREKALAVLL PLVQFEGSVA PDLYCMCGRV 360

YKDMFFSSGF QDAGHREQAY HWYRKAFEVE PSLHSGINAA VLLLAAGQRF EDSEELRLIG 420

MKLGCLLARK GCVEKMQYYW DVGFYLGAQI LANDATQVVL AAEQLYKLNA PIWYLVSVME 480

TFLLYQHFRP TPEPLGGPPR RAHFWLHFLL QSCKPFKPAS PQEDQCLVLV LELNKVLLPA 540

RLEVQGADPV SAVTLSLLEP ETQNKPSSWT FPVASVCGVS TSKRDERCCF LYVLPPAQDV 600

QLCFPSVGHC QWFCGLIQTS VTNPDSTAPA EGAEGVGEVL EFDYEYSETG ERLVLGKGTY 660

GVVYAGRERH TKVRIAIKEI PERDSRFSQP LHKEIALHKR LRHKNIVRYL GSASQGGYLK 720

IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHDNHIVH DIKGDNVLIN 780

TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI 840

EMATGRPPFY ELGSPQAAMF QVGMYKVHPP MPKSLSAEAQ AFLLQTFEPD PRLRASAQAL 900

LGDPFLQPGK KSRSPSSPRH APLPSDVPSA SLTPSADSTT QSQTFPCSQA PSQHPPSPPK 960

RCLSYGGTSR LRVPEKPGAE EPPSPEESSG LSLLHQESKR RAMLAGVLEQ ELSVLADSLR 1020

LEQEQGPQLG RNQVEQLLRC LRAHIHTPNR RQLAQDLRAL QRQLRAQGLG PGLLQGPLFA 1080

FPDAVKQVLR RRQIRPHWMF VLDSLLSRAV RAALAVLGPE VEKEVDSQLS EEPTKDKGSQ 1140

TKQQETLVQC NPLPKEPEYG PPPLMVQLGL LRAETNRLRA VLAEKERECQ ALMQRALQRV 1200

DGEALASEPP AAFPADQGLV QWLQELSVDA VTIQTLLNHS FSLHALLTCV TRDDLSYTHI 1260

RGGMVCRIWR AILEQRAGA 1279

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya+++ +t+ ++a+Ke+   pe++s+   +++l++Ei+l+k+l+H+n

Q: 651   ERLVLGKGTYGVVYAGRERHTKVRIAIKEI---PERDSR--FSQPLHKEIALHKRLRHKN  705

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+

Q: 706   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLSYLHD  765

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivH DiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 766   NHIVH-DIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  821

         *****.***********9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf el++++a+mf+vg+ k++P++p++ls+e+++

Q: 822   GPRGYGKAADIWSLGCTVIEMATGRPPFYELGSPQAAMFQVGMYKVHPPMPKSLSAEAQA  881

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 882   FLLQTFEPDPRLRASAQALLGDPFL  906

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRERH TKVRIAIKEI PERDSRFSQP LHKEIALHKR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHDNHIVH 120

DIKGDNVLIN TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA 180

DIWSLGCTVI EMATGRPPFY ELGSPQAAMF QVGMYKVHPP MPKSLSAEAQ AFLLQTFEPD 240

PRLRASAQAL LGDPFL 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013