EKS-LOA-00226
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00226
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE7369.89.4E-11169362294
StatusUnreviewed
Ensembl ProteinENSLAFP00000005446
UniProt AccessionG3SYA0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP2K1
Gene Synonyms/Alias MAP2K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000006487ENSLAFP00000005446ENSLAFT00000006487
ENSLAFG00000006487ENSLAFP00000028776ENSLAFT00000030774
OrganismLoxodonta africana
Functional Description
Protein Length394
Protein Sequence
(FASTA)
MPKKKPTPIQ LNPAPDGSAV NGTTSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60
GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLLQ PTLAPEVREK CLRQLRSVLH 120
ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQVLKKAG RIPEQILGKV SIAVIKGLTY 180
LREKHKIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240
YSVQSDIWSM GLSLVEMAVG RYPIPPPDAK ELELMFGCHV EGDAAETPPR PRTPGRPLSS 300
YGMDSRPPMA IFELLDYIVN EPPPKLPSGV FSLEFQDFVN KCLIKNPAER ADLKQLMVHT 360
FIKRSDAEEV DFAGWLCSTI GLNQPSTPTH AAGV 394
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrele.vlkkssnspyi  60
         ek++elGaGnggvV kv+hk+sg ++a+K ++ +  +e ++++lr+l+ vl+++ nspyi
Q: 69    EKISELGAGNGGVVFKVSHKPSGLVMARKLLQPTLAPEVREKCLRQLRsVLHEC-NSPYI  127
         799*******************************************96488999.*****
S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120
         v+fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+e
Q: 128   VGFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLRE  183
         ******************************9....8************************
S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYs  180
         k+ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ys
Q: 184   KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYS  242
         *******************************************************.****
S: 181   vksdvWslGltlvelatgrypyeklke.................................  207
         v+sd+Ws+Gl+lve+a+gryp++++++                                 
Q: 243   VQSDIWSMGLSLVEMAVGRYPIPPPDAkelelmfgchvegdaaetpprprtpgrplssyg  302
         *************************999********************************
S: 208   ........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259
                 i+ell++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ h+fi
Q: 303   mdsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHTFI  362
         **********************************************************97
Domain Sequence
(FASTA)
EKISELGAGN GGVVFKVSHK PSGLVMARKL LQPTLAPEVR EKCLRQLRSV LHECNSPYIV 60
GFYGAFYSDG EISICMEHMD GGSLDQVLKK AGRIPEQILG KVSIAVIKGL TYLREKHKIM 120
HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMSPERLQG THYSVQSDIW 180
SMGLSLVEMA VGRYPIPPPD AKELELMFGC HVEGDAAETP PRPRTPGRPL SSYGMDSRPP 240
MAIFELLDYI VNEPPPKLPS GVFSLEFQDF VNKCLIKNPA ERADLKQLMV HTFI 294
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00209
EKS-BOT-00227
EKS-CAJ-00234
EKS-CAF-00233
EKS-CAP-00253
EKS-DAR-00542
EKS-EQC-00219
EKS-FEC-00212
EKS-GAM-00131
EKS-GAG-00189
EKS-GAA-00280
EKS-GOG-00224
EKS-HOS-00234
EKS-LAC-00239
EKS-MAM-00229
EKS-MAE-00004
EKS-MEG-00177
EKS-MOD-00225
EKS-MUM-00232
EKS-MUP-00225
EKS-MYL-00228
EKS-NOL-00211
EKS-OCP-00006
EKS-ORN-00296
EKS-ORA-00198
EKS-ORC-00204
EKS-ORL-00274
EKS-OTG-00232
EKS-PAT-00216
EKS-PES-00202
EKS-POA-00220
EKS-PTV-00008
EKS-RAN-00225
EKS-TAG-00243
EKS-TAS-00005
EKS-TEN-00286
EKS-TUB-00009
EKS-XET-00304
EKS-XIM-00289
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0004728; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050; P:cell cycle arrest
GO:0048870; P:cell motility
GO:0090398; P:cellular senescence
GO:0030216; P:keratinocyte differentiation
GO:0060711; P:labyrinthine layer development
GO:0008285; P:negative regulation of cell proliferation
GO:0030182; P:neuron differentiation
GO:0060674; P:placenta blood vessel development
GO:0045597; P:positive regulation of cell differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013