EPS-LOA-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	269.4	4.8E-80	55	365	311

Status

Unreviewed

Ensembl Protein

ENSLAFP00000005530

UniProt Accession

G3SYF7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000006586	ENSLAFP00000005530	ENSLAFT00000006586

Organism

Loxodonta africana

Functional Description

Protein Length

597

Protein Sequence
(FASTA)

MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSPSQPSP PQPEVSGKGP 60

AVAAREARGP PPDAGASPDP SRCCRRRSSV AFFAVCDGHG GREAAQFARE HLWSFIKKQK 120

GFTSSEPAKV CAAIRKGFLA CHLAMWKKLA EWPKTMTGLP STSGTTASVV IIRGMKMYVA 180

HVGDSGVVFG VQDDPKDDFI RAVEVTQDHK PELPKERERI EGLGGSVMNK SGVNRVVWKR 240

PRLTHNGPVR RSTVIDQIPF LAVARALGDL WSYDFFSGEF VVSPEPDTSV HTLDPQKHKY 300

IILGSDGLWN MIPPQDAISM CQDQEEKKCL MGEHGQSCAK MLVNRALGRW RQRMLRADNT 360

SAIVICISPG ADLQGSFANE DELYLNLTDS PFYNSQETCV MTPSPCSTPP VKSLEEDPWP 420

RLNSKDHIPA LVRSNAFSEN SLEIPAEIAR GNVQAVVIPS KDPEPLEENC TKALTLRIHD 480

SLNNSLSVGL VPTNSTNTIM DQKNLKMSTP GQMKAQEVER TPPANFKRTL EESNSGPLMK 540

KHKRNSLSRS SGAQSASLPT TSQRKNSVKL TMRRRLRGQK KIGNPLLHQH RKTVCVY 597

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCGCT GGGAGTGAGC GTCTTCTCCG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TTACTCAAAT CGTTGTGGAG CCCGAGCCGA CGGCCGAAGA AAAGCCCTCG 120

CCGCGGCGGT CGCCCTCTCA GCCGTCGCCT CCGCAGCCCG AAGTCTCGGG GAAAGGCCCG 180

GCAGTGGCAG CCCGAGAAGC CCGCGGTCCT CCCCCGGACG CCGGCGCTTC GCCGGATCCC 240

AGCCGCTGCT GCCGCCGCCG TTCCTCCGTT GCATTTTTCG CAGTGTGCGA CGGGCACGGC 300

GGGCGGGAGG CGGCACAGTT TGCCCGGGAG CATTTGTGGA GTTTCATCAA GAAACAGAAG 360

GGTTTCACCT CGTCCGAGCC GGCGAAGGTT TGCGCTGCCA TCCGCAAAGG CTTCCTCGCC 420

TGTCACCTCG CCATGTGGAA GAAACTGGCA GAATGGCCCA AGACTATGAC AGGTCTTCCC 480

AGCACGTCAG GGACAACTGC CAGCGTGGTC ATCATACGGG GCATGAAGAT GTATGTAGCT 540

CATGTGGGAG ACTCAGGGGT GGTTTTTGGA GTTCAGGATG ACCCAAAGGA TGATTTTATC 600

AGAGCTGTGG AGGTGACACA GGACCATAAG CCAGAACTTC CCAAGGAAAG AGAGCGAATC 660

GAAGGACTTG GTGGGAGTGT GATGAACAAG TCTGGAGTGA ATCGTGTAGT TTGGAAACGA 720

CCTCGACTCA CTCACAATGG ACCTGTACGA AGGAGCACAG TTATTGACCA AATCCCTTTT 780

CTGGCAGTAG CAAGAGCACT TGGTGATTTG TGGAGCTATG ATTTCTTTAG CGGTGAGTTT 840

GTTGTGTCAC CTGAACCAGA CACAAGCGTC CACACTCTTG ACCCCCAGAA GCACAAGTAT 900

ATTATCTTGG GTAGTGATGG ACTCTGGAAT ATGATTCCAC CTCAAGATGC CATCTCAATG 960

TGCCAGGACC AAGAGGAGAA AAAATGCTTG ATGGGTGAGC ACGGACAATC TTGTGCCAAA 1020

ATGCTAGTGA ATCGAGCCCT AGGCCGGTGG AGGCAGCGTA TGCTCCGAGC AGATAATACT 1080

AGTGCCATAG TAATCTGCAT CTCTCCAGGA GCGGACCTCC AGGGCAGCTT TGCCAATGAA 1140

GATGAGCTGT ATCTGAACCT GACTGATAGT CCTTTCTATA ATAGTCAAGA AACCTGTGTG 1200

ATGACTCCTT CCCCCTGTTC TACACCACCA GTCAAGTCAC TGGAGGAGGA TCCATGGCCA 1260

AGACTGAACT CTAAGGACCA TATACCTGCT CTTGTTCGTA GTAATGCCTT CTCAGAGAAT 1320

TCTTTAGAGA TCCCAGCTGA GATAGCTCGA GGGAATGTCC AGGCTGTAGT CATACCCTCA 1380

AAAGATCCAG AGCCACTTGA GGAAAATTGC ACTAAAGCCC TGACTTTAAG GATACATGAT 1440

TCCTTGAATA ATAGTCTGTC AGTTGGCCTT GTGCCTACAA ATTCAACAAA CACTATCATG 1500

GACCAAAAAA ACTTAAAGAT GTCAACTCCT GGTCAAATGA AAGCCCAAGA AGTGGAAAGA 1560

ACCCCTCCAG CAAACTTTAA AAGGACATTG GAAGAATCCA ACTCTGGCCC CCTTATGAAG 1620

AAGCATAAAC GAAATAGTTT GAGTCGAAGT AGCGGTGCTC AGTCTGCAAG CCTCCCCACA 1680

ACCTCGCAGC GAAAGAACTC TGTTAAACTT ACCATGCGAC GCAGACTTAG GGGTCAGAAG 1740

AAAATTGGAA ATCCCTTACT ACATCAGCAC CGAAAAACTG TTTGTGTTTA CTGA 1794

Domain Profile

S: 6     vsvngrrnemedavtsspnflkspekkdr......laffgvyDGhggsevakfcseklhe  59

         vs++g+    ++a+ + p++++sp+ +++      +aff+v+DGhgg+e+a+f++e+l++

Q: 55    VSGKGPAVAAREARGPPPDAGASPDPSRCcrrrssVAFFAVCDGHGGREAAQFAREHLWS  114

         788999999999999***********999*******************************

S: 60    ilaeelesseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvalikd  114

         ++++++ +++se +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i++

Q: 115   FIKKQKGFTSSEPAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVIIRG  174

         ************************************************************

S: 115   sklyvanvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdga.  166

         +k+yva+vGdS++v++ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g+

Q: 175   MKMYVAHVGDSGVVFGVQDDpkddfirAVEVTQDHKPELPKERERIEGLGGSVMNKSGVn  234

         *****************77656999999********************************

S: 167   Rv.....................lGvLavsRalGdlylk......pyvtpePevtshrlt  199

         Rv                     +++Lav+RalGdl+++      ++v+peP++++h+l+

Q: 235   RVvwkrprlthngpvrrstvidqIPFLAVARALGDLWSYdffsgeFVVSPEPDTSVHTLD  294

         ************************************************************

S: 200   sede.fliLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk..  252

         ++++ ++iL+sDGlw+++++++a+s+++d++e    ++e+ q++ak+Lv++al r+++

Q: 295   PQKHkYIILGSDGLWNMIPPQDAISMCQDQEEkkclMGEHGQSCAKMLVNRALGRWRQrm  354

         ************************************************************

S: 253   ...dnvsaivv  260

            dn+saiv+

Q: 355   lraDNTSAIVI  365

         *********97

Domain Sequence
(FASTA)

VSGKGPAVAA REARGPPPDA GASPDPSRCC RRRSSVAFFA VCDGHGGREA AQFAREHLWS 60

FIKKQKGFTS SEPAKVCAAI RKGFLACHLA MWKKLAEWPK TMTGLPSTSG TTASVVIIRG 120

MKMYVAHVGD SGVVFGVQDD PKDDFIRAVE VTQDHKPELP KERERIEGLG GSVMNKSGVN 180

RVVWKRPRLT HNGPVRRSTV IDQIPFLAVA RALGDLWSYD FFSGEFVVSP EPDTSVHTLD 240

PQKHKYIILG SDGLWNMIPP QDAISMCQDQ EEKKCLMGEH GQSCAKMLVN RALGRWRQRM 300

LRADNTSAIV I 311

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013