EPS-LOA-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	619.1	1.4E-186	145	456	312

Status

Unreviewed

Ensembl Protein

ENSLAFP00000005652

UniProt Accession

G3SYQ8;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000006728	ENSLAFP00000020489	ENSLAFT00000031346
ENSLAFG00000006728	ENSLAFP00000005652	ENSLAFT00000006729

Organism

Loxodonta africana

Functional Description

Protein Length

459

Protein Sequence
(FASTA)

AKDYENAIKF YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALADATRAIE LDKKYIKGYY 60

RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS 120

VVDSLDIESM TIEDEYSGPK LEDGRVTITF MKELMQWYKD QKKLHRKCAY QILVQVKEVL 180

SKLSTLVETT LKETEKITVC GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV 240

EVILTLFGFK LLYPDHFHLL RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL 300

AQCINGKVLI MHGGLFSEDG ITLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR 360

GVSCQFGPDV TKAFLEENHL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS 420

YIHLRGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM 459

Nucleotide Sequence
(FASTA)

GCCAAGGACT ATGAGAACGC CATCAAGTTC TACAGCCAGG CCATTGAGCT GAACCCCAGC 60

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACCGAGTG CTATGGCTAC 120

GCACTGGCTG ATGCCACACG GGCCATTGAA CTTGACAAGA AGTACATCAA GGGCTACTAC 180

CGCCGGGCCG CCAGCAACAT GGCACTGGGC AAGTTTCGAG CTGCCCTGCG TGACTATGAG 240

ACGGTGGTGA AGGTGAAGCC CCATGACAAA GATGCTAAAA TGAAATACCA GGAGTGCAAC 300

AAGATCGTGA AGCAGAAGGC TTTCGAGCGG GCCATTGCGG GTGATGAGCA CAAGCGCTCC 360

GTCGTGGACT CGCTGGACAT CGAGAGCATG ACCATCGAGG ACGAGTACAG TGGGCCCAAG 420

CTCGAGGACG GCAGAGTGAC AATCACCTTC ATGAAAGAGC TCATGCAGTG GTACAAGGAT 480

CAGAAGAAAC TGCACCGGAA GTGTGCCTAC CAGATTCTGG TACAGGTCAA AGAAGTCCTC 540

TCAAAGCTGA GCACGCTCGT GGAGACTACA CTCAAAGAGA CAGAGAAGAT TACAGTGTGC 600

GGGGACACCC ACGGCCAGTT CTATGACCTT CTCAACATAT TTGAACTCAA CGGTTTACCC 660

TCTGAGACCA ACCCCTACAT ATTTAATGGT GACTTTGTGG ACCGCGGCTC CTTCTCCGTA 720

GAAGTGATCC TCACCCTTTT CGGCTTTAAG CTCCTGTACC CAGATCACTT CCACCTACTT 780

CGAGGCAATC ATGAGACAGA CAACATGAAC CAGATCTACG GCTTCGAGGG CGAGGTGAAG 840

GCCAAGTACA CAGCCCAGAT GTACGAGCTG TTCAGCGAGG TGTTCGAATG GCTCCCGCTG 900

GCCCAGTGTA TCAATGGCAA AGTGCTGATC ATGCATGGGG GCTTGTTCAG TGAAGATGGC 960

ATCACCCTGG ATGATATTCG GAAGATTGAG CGAAATCGGC AGCCCCCAGA CTCAGGTCCC 1020

ATGTGTGACC TGCTCTGGTC AGACCCGCAG CCGCAGAACG GACGCTCCGT CAGCAAGCGA 1080

GGTGTGAGCT GCCAGTTCGG GCCTGACGTC ACCAAGGCCT TCCTGGAGGA GAACCACCTG 1140

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ATGAGGTGGC ACACGGTGGC 1200

CGCTGCGTCA CCGTCTTCTC TGCCCCCAAC TACTGTGACC AGATGGGGAA TAAAGCTTCG 1260

TACATCCACC TCCGGGGCTC TGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1320

CATCCCAACG TCAAGCCCAT GGCCTATGCC AACACGCTGC TGCAGTTAGG AATGATGTGA 1380

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         +v+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 145   RVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  204

         6899********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 205   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  264

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedg+tld

Q: 265   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGITLD  324

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 325   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENHLDYII  384

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hp+v

Q: 385   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPNV  444

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 445   KPMAYANTLLQL  456

         *********997

Domain Sequence
(FASTA)

RVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGITLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013