EKS-LOA-00287
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00287
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR453.34.2E-136208495288
StatusUnreviewed
Ensembl ProteinENSLAFP00000005769
UniProt AccessionG3TUY1;
Protein Name
Protein Synonyms/Alias
Gene NameACVR1
Gene Synonyms/Alias ACVR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000006865ENSLAFP00000019389ENSLAFT00000031124
ENSLAFG00000006865ENSLAFP00000005769ENSLAFT00000006864
OrganismLoxodonta africana
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MVNGVMILPV LMMIAFPSPS MEDEKPKANP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60
DGYHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120
HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180
ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480
NPSARLTALR IKKTLTKIDN SLDKLKTDC 509
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia
Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267
         789*********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+
Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE
Q: 328   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m
Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444
         **********************************9.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l
Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495
         *************************************************97
Domain Sequence
(FASTA)
ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60
SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120
GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180
DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240
VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00259
EKS-ANC-00266
EKS-BOT-00277
EKS-CAJ-00284
EKS-CAF-00283
EKS-CAP-00312
EKS-CIS-00045
EKS-DAR-00618
EKS-DRM-00143
EKS-EQC-00269
EKS-FEC-00264
EKS-GAM-00173
EKS-GAG-00231
EKS-GAA-00339
EKS-GOG-00276
EKS-HOS-00284
EKS-LAC-00291
EKS-MAM-00279
EKS-MEG-00221
EKS-MIM-00019
EKS-MOD-00275
EKS-MUM-00310
EKS-MUP-00272
EKS-MYL-00280
EKS-NOL-00254
EKS-ORN-00357
EKS-ORA-00242
EKS-ORC-00261
EKS-ORL-00334
EKS-OTG-00283
EKS-PAT-00261
EKS-PES-00246
EKS-PEM-00150
EKS-POA-00269
EKS-RAN-00294
EKS-SAH-00261
EKS-SUS-00244
EKS-TAG-00290
EKS-TAR-00359
EKS-TEN-00356
EKS-XET-00351
EKS-XIM-00350
Gene Ontology
GO:0045177; C:apical part of cell
GO:0005887; C:integral to plasma membrane
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005025; F:transforming growth factor beta receptor activity, type I
GO:0002526; P:acute inflammatory response
GO:0003289; P:atrial septum primum morphogenesis
GO:0030509; P:BMP signaling pathway
GO:0060923; P:cardiac muscle cell fate commitment
GO:0007368; P:determination of left/right symmetry
GO:0003143; P:embryonic heart tube morphogenesis
GO:0003197; P:endocardial cushion development
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0001702; P:gastrulation with mouth forming second
GO:0007281; P:germ cell development
GO:0001701; P:in utero embryonic development
GO:0001707; P:mesoderm formation
GO:0003183; P:mitral valve morphogenesis
GO:0032926; P:negative regulation of activin receptor signaling pathway
GO:0043066; P:negative regulation of apoptotic process
GO:0001755; P:neural crest cell migration
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0001569; P:patterning of blood vessels
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0060037; P:pharyngeal system development
GO:0030501; P:positive regulation of bone mineralization
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014; P:signal transduction by phosphorylation
GO:0051145; P:smooth muscle cell differentiation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013