EKS-LOA-00185

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00185

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CASK	542.0	2.7E-163	12	276	265

Status

Unreviewed

Ensembl Protein

ENSLAFP00000005834

UniProt Accession

G3SZ61;

Protein Name

Protein Synonyms/Alias

Gene Name

CASK

Gene Synonyms/Alias

CASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000006945	ENSLAFP00000005834	ENSLAFT00000006946
ENSLAFG00000006945	ENSLAFP00000018468	ENSLAFT00000028041
ENSLAFG00000006945	ENSLAFP00000025181	ENSLAFT00000033168

Organism

Loxodonta africana

Functional Description

Protein Length

926

Protein Sequence
(FASTA)

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60

REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120

YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180

GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240

QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300

RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGN LIIQGAVSQV LDSLEEIHAL 360

TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEEISCYP 420

ENNDAKELKR ILTQPHFMAL LQTHDVVAHE VYSDEALRVT PPPTSPYLNG DSPESANGDM 480

DMENVTRVRL VQFQKNTDEP MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN 540

GISVANQTVE QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS 600

VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS KDDHNWWQGK 660

LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW FGKKKKQYKD KYLAKHNAVF 720

DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK 780

DEENGKNYYF VSHDQMMQDI SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ 840

ALKVLRTAEF APFVVFIAAP TITPGLNEDE SLQRLQKESD ILQRTYAHYF DLTIINNEID 900

ETIRHLEEAI ELVCTAPQWV PVSWVY 926

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60

         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh

Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71

         89**********************************************************

S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120

         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry

Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131

         ************************************************************

S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180

         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev

Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190

         ****************************************.*******************

S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240

         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak

Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250

         ************************************************************

S: 241   dlvrrmlaadpakrisvkealnhewl  266

         dlvrrml++dpa+ri+v+ealnh+wl

Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276

         *************************7

Domain Sequence
(FASTA)

YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60

PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120

CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180

KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240

LVRRMLMLDP AERITVYEAL NHPWL 265

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005604	; C:basement membrane
GO:0016323	; C:basolateral plasma membrane
GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005652	; C:nuclear lamina
GO:0016363	; C:nuclear matrix
GO:0005730	; C:nucleolus
GO:0045202	; C:synapse
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070509	; P:calcium ion import
GO:0001953	; P:negative regulation of cell-matrix adhesion
GO:0090288	; P:negative regulation of cellular response to growth factor stimulus
GO:0010839	; P:negative regulation of keratinocyte proliferation
GO:0061045	; P:negative regulation of wound healing
GO:0090280	; P:positive regulation of calcium ion import
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

InterPros

IPR008144	; Guanylate_kin.
IPR008145	; Guanylate_kin/L-typ_Ca_channel.
IPR020590	; Guanylate_kinase_CS.
IPR011009	; Kinase-like_dom.
IPR004172	; L27.
IPR014775	; L27_C.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.

Pfam

PF00625	; Guanylate_kin; 1.
PF02828	; L27; 2.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00072	; GuKc; 1.
SM00569	; L27; 2.
SM00228	; PDZ; 1.
SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00856	; GUANYLATE_KINASE_1; 1.
PS50052	; GUANYLATE_KINASE_2; 1.
PS51022	; L27; 2.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013