EKS-LOA-00416
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00416
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK399.78.9E-120180458279
StatusUnreviewed
Ensembl ProteinENSLAFP00000006141
UniProt AccessionG3SZR9;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000007307ENSLAFP00000006141ENSLAFT00000007307
OrganismLoxodonta africana
Functional Description
Protein Length588
Protein Sequence
(FASTA)
AAGNRGAPGA LSARTLLFDL PPALLGELCA VLDSCDGPLG WRGLAERLSS SWLDVRHIEK 60
HVEQGKSGTR ELLWSWAQKN KTIGDLLQIL QEMGHHRAIH LITNHGAAWN PSVPSHQRNE 120
FPNMPSKVQC VCLDNDPCDL SEETANVTVD NVHVPERNEK GMLLRSSISF QSIIEGTQNF 180
HKGFLIGEGE VFEVYRAEIQ NRAYAIKLFK QEKKMLCKKQ WKKFLSELEV LLLFHHPNIL 240
ELAAYFTETE KFCLVYPYMR NGSLFDRLQC VGKTAPLSWH IRIEVLIGTS KAIQYLHNTE 300
PCSVICGSIS SANILLDDQF QPKLTDFGMA HFRPHLEHQS STINMNNSSS KHLWYMPEEY 360
IRQGKLSIKT DVYSFGIVIM EVLTGCKVVL DDPKHIQLRD LLMELMEKRG LDSCLSFLDK 420
KVDPCPRNFS AKLFSLACQC ATTRAKLRPL MDEVLNTLES TQASLYFAED PPTSLKSFRC 480
PSPLFLDNVP SIPVEDDENQ NIRSLPHGKD LREDRMTQKI PFECSQSEVT FLGFDGKAGS 540
WRNEDACNTR GSCEKSWSPK HEAPSQDLGA CDMNVDTSSE AAADSHGT 588
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f++++ igeG+ +evyr+e++n a+a+k +k+e+++ +k+ +++fl+El+vl+ f+H+ni
Q: 180   FHKGFLIGEGEVFEVYRAEIQNRAYAIKLFKQEKKMLCKKQWKKFLSELEVLLLFHHPNI  239
         8999********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel++y++e+ek+cLvY+ym+nGsL+drLqc ++++pLsW++R+++l+Gt++ai++LH++
Q: 240   LELAAYFTETEKFCLVYPYMRNGSLFDRLQCVGKTAPLSWHIRIEVLIGTSKAIQYLHNT  299
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +p s+i+g+i+saNiLLD++++pKl+Dfg+a+f+p+ e+qsst+++ ++ +++l+Y+pee
Q: 300   EPcSVICGSISSANILLDDQFQPKLTDFGMAHFRPHLEHQSSTINMNNSSSKHLWYMPEE  359
         ************************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         +ir+g+l++k+DvySfGiV++EvltG+++v +d+k+ +L+dll+e +e+++++++ +fld
Q: 360   YIRQGKLSIKTDVYSFGIVIMEVLTGCKVVLDDPKHIQLRDLLMELMEKRGLDSCLSFLD  419
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+ +++++++++l++la++c+ ++ak rP m++vl++l
Q: 420   KKVDPCPRNFSAKLFSLACQCATTRAKLRPLMDEVLNTL  458
         ***********************************9987
Domain Sequence
(FASTA)
FHKGFLIGEG EVFEVYRAEI QNRAYAIKLF KQEKKMLCKK QWKKFLSELE VLLLFHHPNI 60
LELAAYFTET EKFCLVYPYM RNGSLFDRLQ CVGKTAPLSW HIRIEVLIGT SKAIQYLHNT 120
EPCSVICGSI SSANILLDDQ FQPKLTDFGM AHFRPHLEHQ SSTINMNNSS SKHLWYMPEE 180
YIRQGKLSIK TDVYSFGIVI MEVLTGCKVV LDDPKHIQLR DLLMELMEKR GLDSCLSFLD 240
KKVDPCPRNF SAKLFSLACQ CATTRAKLRP LMDEVLNTL 279
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00378
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-FEC-00390
EKS-GAA-00494
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-MAM-00405
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TUT-00121
EKS-VIP-00063
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
SM00005; DEATH; 1.
Prosites
PS50017; DEATH_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013