EKS-LOA-00010

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00010

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	492.3	2.7E-148	616	872	257

Status

Unreviewed

Ensembl Protein

ENSLAFP00000021870

UniProt Accession

G3T0H8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA2

Gene Synonyms/Alias

EPHA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000007699	ENSLAFP00000021870	ENSLAFT00000030470
ENSLAFG00000007699	ENSLAFP00000006472	ENSLAFT00000007701

Organism

Loxodonta africana

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MERRAARACL ALLWGCALAA VVAAAAQGKE VVLLDFAAAK GELGWLTQPY GKGWDLMQSI 60

MDDKPIYMYS VCNVVAGDQD NWLRTNWVYR GEAERIFIEL KFTVRDCNSF PGGASSCKET 120

FNLYYAESDV DYGTNFQKRH FTKIDTIAPD EITVSSDFQA RHVKLNVEER SVGPLSHKGF 180

YLAFQDIGAC VALLSVRVYY KKCPELLQGL AHFPETIAGS DAPSLATVAG TCVNHAVVPP 240

GGEEPRIHCT VDGEWLVPIG QCLCQAGYEK VEDACQVASP GFFKSEASES PCLECPAHTL 300

PSLEGATSCE CEEGYFRAPH DPLAEPCTRP PSAPHYLTAV GMGAKVELRW TPPQDSGGRE 360

DVVYSVTCEQ CWPESGECGP CEDSVRYSEP PHELTRTSLT VSDLEPHMNY TFAVEARNGV 420

SGLVTSRSFR TASVSINQTE PPKVRLEGRT TTSLSVSWSI PLRQQSRVWK YEVTYRKKGD 480

SNSYNVRRTE GFSVILDDLI PDTTYLVQVQ ALTQEGQGAG SKMHEFQTLS TEGSGNMTVI 540

GGVIVGVVFL LVLIGIGFFL HRRRSNLRAR RSSEDVYFSK SEQLKPLKTY VDPHTYEDPN 600

QAVLKFTTEI HPSCVTRQKV IGAGEFGEVY KGTLKASGKK EVPVAIKTLK AGYTEKQRVD 660

FLSEASIMGQ FSHHNIIRLE GVVSKYKPMM IITEYMENGA LDKFLREKDG EFSVLQLVGM 720

LRGIAAGMKY LANMNYVHRD LAARNILVNS NLVCKVSDFG LSRVLEDDPE ATYTTSGGKI 780

PIRWTAPEAI SYRKFTSASD VWSYGIVMWE VMTYGERPYW ELSNHEVMKA INDGFRLPTP 840

MDCPSAIYQL MMQCWQQERA RRPKFADIVS ILDKLIRAPD SLKTLADFDP RVSIRLPSTS 900

GSEGVPFRTV SEWLESIKMQ QYTEHFMTAG YTVIEKVVQM TNDDIKRIGV RLPGHQKRIA 960

YSLLGLKDQV NTVGIPI 977

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61

         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n

Q: 616   TRQKVIGAGEFGEVYKGTLKASGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHN  675

         6789********************************************************

S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121

         iirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGia+gmkyl++m+

Q: 676   IIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN  735

         ************************************************************

S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181

         yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf

Q: 736   YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  795

         ************************************************************

S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241

         tsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++cw

Q: 796   TSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCW  855

         ************************************************************

S: 242   qkdraerpkfeqivsil  258

         q++ra+rpkf++ivsil

Q: 856   QQERARRPKFADIVSIL  872

         **************985

Domain Sequence
(FASTA)

TRQKVIGAGE FGEVYKGTLK ASGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFSHHN 60

IIRLEGVVSK YKPMMIITEY MENGALDKFL REKDGEFSVL QLVGMLRGIA AGMKYLANMN 120

YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180

TSASDVWSYG IVMWEVMTYG ERPYWELSNH EVMKAINDGF RLPTPMDCPS AIYQLMMQCW 240

QQERARRPKF ADIVSIL 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005925	; C:focal adhesion
GO:0005887	; C:integral to plasma membrane
GO:0031256	; C:leading edge membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity
GO:0032863	; P:activation of Rac GTPase activity
GO:0006915	; P:apoptotic process
GO:0048320	; P:axial mesoderm formation
GO:0046849	; P:bone remodeling
GO:0060444	; P:branching involved in mammary gland duct morphogenesis
GO:0060326	; P:cell chemotaxis
GO:0030216	; P:keratinocyte differentiation
GO:0070309	; P:lens fiber cell morphogenesis
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0021915	; P:neural tube development
GO:0030182	; P:neuron differentiation
GO:0060035	; P:notochord cell development
GO:0014028	; P:notochord formation
GO:0001649	; P:osteoblast differentiation
GO:0030316	; P:osteoclast differentiation
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491	; P:protein kinase B signaling cascade
GO:0045765	; P:regulation of angiogenesis
GO:0043535	; P:regulation of blood vessel endothelial cell migration
GO:0033628	; P:regulation of cell adhesion mediated by integrin
GO:0070372	; P:regulation of ERK1 and ERK2 cascade
GO:0010591	; P:regulation of lamellipodium assembly
GO:0070848	; P:response to growth factor stimulus
GO:0001501	; P:skeletal system development
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013