EKS-LOA-00165
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00165
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG495.34.1E-149453711259
StatusUnreviewed
Ensembl ProteinENSLAFP00000006517
UniProt AccessionG3T0L2;
Protein NamecGMP-dependent protein kinase
Protein Synonyms/Alias
Gene NamePRKG2
Gene Synonyms/Alias PRKG2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000007763ENSLAFP00000006517ENSLAFT00000007765
OrganismLoxodonta africana
Functional Description
Protein Length762
Protein Sequence
(FASTA)
MGNGSVKPKH SKNPDGHSGN FTIDALRSKV TELERELRRK DVEIQEREYH LKELREQLSK 60
QTVAIAELTE ELQNKCIQLN KLQDVVLMQG GSLPQASPDK VPLEVHRKTS GLVSLHSRRG 120
AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180
VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GQIEVFQGEK LLSSIPMWTT FGELAILYNC 240
TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300
CLEVEYYDKG DYIIREGEEG STFYILAKGK VKVTQSTEGH EQPQLIKVLQ KGEYFGEKAL 360
ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420
MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480
MKCIRKRHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540
ILRDRGSFDE PTSKFCVACV TEAFDYLHQL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660
LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720
ARNLPSPLKR ELSGPTDHSY FDKYPPEKGI PPDELSGWDK DF 762
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l++iatlgvggfgrvelvkvk+ e+ afa+k+++k+hivdtkqqehv+sekrilee++s+
Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKRHIVDTKQQEHVYSEKRILEELCSP  511
         689******************9.999**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +
Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHQLG  571
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv
Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np
Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         +erlg+lk+gi+dikkh+w+
Q: 692   TERLGNLKNGINDIKKHRWL  711
         *******************7
Domain Sequence
(FASTA)
LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKRHIVDT KQQEHVYSEK RILEELCSPF 60
IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHQLGI 120
IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180
FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240
ERLGNLKNGI NDIKKHRWL 259
KeywordATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00158
EKS-ANC-00160
EKS-BOT-00166
EKS-CAJ-00170
EKS-CAF-00173
EKS-CAP-00165
EKS-DAR-00456
EKS-DRM-00080
EKS-EQC-00165
EKS-FEC-00155
EKS-GAM-00085
EKS-GAG-00142
EKS-GAA-00197
EKS-GOG-00165
EKS-HOS-00172
EKS-ICT-00161
EKS-LAC-00176
EKS-MAM-00164
EKS-MEG-00131
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORN-00207
EKS-ORA-00147
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PEM-00088
EKS-POA-00162
EKS-PTV-00148
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TAG-00195
EKS-TAR-00214
EKS-VIP-00079
EKS-XET-00154
EKS-XIM-00202
Gene Ontology
GO:0005524; F:ATP binding
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR016232; cGMP-dependent_protein_kinase.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013