EKS-LOA-00020
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00020
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/Trio369.61.0E-11026872941255
StatusUnreviewed
Ensembl ProteinENSLAFP00000024177
UniProt AccessionG3T0T2;
Protein Name
Protein Synonyms/Alias
Gene NameTRIO
Gene Synonyms/Alias TRIO;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000007860ENSLAFP00000006607ENSLAFT00000007868
ENSLAFG00000007860ENSLAFP00000024177ENSLAFT00000036668
OrganismLoxodonta africana
Functional Description
Protein Length2984
Protein Sequence
(FASTA)
LSISGFRKND EMKAMDVLPI LKEKVAYLSG GRDKRGGPIL TFPARSNHDR IRQEDLRRLI 60
SYLACIPSEE VCKRGFTVIV DMRGSKWDSI KPLLKVLQES FPRCIHVALI IKPDNFWQKQ 120
RTNFGSSKFE FETNMVSLEG LTKVVDPSQL TPEFDGCLEY NHEEWIEIRV AFEDYVSNAT 180
HMLSRLEELQ DILAKKELPQ DLEGARNMIE EHSQMKKKVI KAPIEDLDLE GQKLLQRIQS 240
SDSFPKKNSG SGNVDLQSLV PKVSSMLDRL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD 300
AEKMFDWITH NKGLFLNSYT EIGTSHPHAM ELQTQHNHFA MNCMNVYVNI NRIMSVANRL 360
VESGHYASQQ IKQIANQLEQ EWKAFAAALD ERSTLLDMSS IFHQKAEKYM SNVDSWCKAC 420
GEVDLPSELQ DLEDAIHHHQ GIYEHITLAY SEVSQDGKSL LDKLQRPLTP GSSDSLTASA 480
NYSKAVHHVL DVIHEVLHHQ RQLENIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA 540
FLSKHTGVGK SLHRARALQK RHEDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYQA 600
AHQLEDRIQD FVRRVEQRKI LLDMSVSFHT HVKELWTWLE ELQKELLDDV YAESVEAVQD 660
LIKRFGQQQQ TTLQVTVNVI KEGEDLIQQL RSGHTHLTSL LLCRDSAISS NKTPHNSSIN 720
HIETVLQQLD EAQSQMEELF QERKIKLELF LQLRIFERDA IDIISDLESW NDELSQQMND 780
FDTEDLTIAE QRLQHHADKA LTMNNLTFDV IHQGQDLLQY VNEVQASGVE LLCDRDVDMA 840
TRVQDLLEFL HEKQQELDLA AEQHRKHLEQ CVQLRHLQAE VKQVLGWIRN GESMLNAGLI 900
TASSLQEAEQ LQREHEQFQH AIEKTHQSAL QVQQKAEAML QANHYDMDMI RDCAEKVASH 960
WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYK REEDWCGGAD KLGPNSETDH 1020
VTPMISKHLE QKEAFLKACT LARRNADVFL KYLHRNSVNM PGMVTHIKAP EQQVKNILNE 1080
LFQRENRVLH YWTMRKRRLD QCQQYVVFER SAKQALEWIH DNGEFYLSTH TSTGSSIQHT 1140
QELLKEHEEF QITAKQTKER VKLLIQLADG FCEKGHAHAA EIKKCVTAVD KRYRDFSVRM 1200
EKYRTSLEKA LGISSDSNKS SKSLQLDIIP ASTPGSEVKL RDAAHELNEE KRKSARRKEF 1260
IMAELIQTEK AYVRDLRECM DTYLWEMTSG VEEIPPGIVN KELVIFGNMQ EIYEFHNNIF 1320
LKELEKYEQL PEDVGHCFVT WADKFQMYVT YCKNKPDSTQ LILEHAGSYF DEIQQRHGLA 1380
NSISSYLIKP VQRITKYQLL LKELLTCCEE GKGEIKDGLE VMLSVPKRAN DAMHLSMLEG 1440
FDENIESQGE LFLQESFQVW DPKTLIRKGR ERHLFLFEMS LVFSKEVKDS SGRSKYLYKS 1500
KLFTSELGVT EHVEGDPCKF ALWVGRTPTS DNKIVLKASS IENKQDWIKH IREVIQERTI 1560
HLKGALKEPI HIPKTAPATR QKGRRDGEDL DSQGDGSSQP DTISIASRTS QNTLDSDKLS 1620
GGCELTVVIH DFTACNSNEL TIRRGQTVEV LERPHDKPDW CLVRTTDRSP AAEGLVPCGS 1680
LCIAHSRSSM EMEGIFNHKD SYSVDTTEGF GKVSSILNAN SQPHMIGAQS SPGPKRPGNT 1740
LRKWLTSPVR RLSSGKADGH VKKLAHKHKK SREVRKSVDA GSQKDSDDSA ATPQDETIEE 1800
SSSSGMQSCG EEEGEEGADA VPLPPPMAIQ QHSLLQPDSQ DDKASSRLLV RPTSSETPSA 1860
AELVSAIEEL VKSKMTLELS QYKGDSSSPS FNPSDNSLLS SSSPIDEMEE RKSSSLKRRH 1920
YVLQELVETE RDYVRDLGYV VEGYMALMKE DGVPDDMKGK DKIVFGNIHQ IYDWHRDFFL 1980
GELEKCLEDP EKLGSLFVKH ERRLHMYIVY CQNKPKSEHI VSEYIDTFFE DLKQRLGHRL 2040
QLTDLLIKPV QRIMKYQLLL KDFLKYSKKA SLDTSELERA VEVMCIVPKR CNDMMNVGRL 2100
QGFDGKIVAQ GKLLLQDTFL VTDQDTGLLP RCKERRVFLF EQIVIFSEPL DKKKGFSMPG 2160
FLFKNSIKVS CLCLEENVEN DPCKFALTSR TGDVVETFIL HSSSPSVRQT WIHEINQILE 2220
NQRNFLNALT SPIEYQRKGQ VSVSMQTQPE KEVPVAQGGP KPAAPAGSRE SPGSASAQSS 2280
PPVPPYQLYT SSQDRGAWCH PHPPATGRRD LGKMQSESSS SSNISTMLVT HDYTAVKEDE 2340
INVYQGEVVQ ILASNQQNMF LVFRAATDQC PAAEGWIPGF VLGHTSTVVL ENPDGTLKKS 2400
TSWHTALRLR KKSEKKDKDG KREGKLENGY GKSRAGLSNK VSVKQTSPER ESKHLGRARA 2460
ATYELLNPNY IYDVPPEFVI PLSEVTCETG ETVVLRCRVC GRPKASITWK GPEHNTLNND 2520
GHYSISYSDL GEAALKIVGA TTEDDGLYTC IAVNDMGAAS SSASLRVLAV QGRPTRPLEE 2580
EAVCVGHIIH LLPPASSALC CFVFIAPQTL DKRAQMWTWF KEISFQMTTW AEVRPPGLRL 2640
YIFKRNAWEQ MGTALPTADG QPTGFSPLSP GSDGIMVTWK DNFDAFYSEV AELGRGRFSV 2700
VKKCDQKGTK RAVATKFVNK KLMKRDQVTH ELGILQNLQH PLLVGLLDTF ETPTSYVLVL 2760
EMADQGRLLD CVVRWGNLTE GKIRMYLGEV LEAVRYLHNC RIAHLDLKPE NILVDQSSAK 2820
PTIKLADFGD AVQLNTTYYI HPLLGNPEFS APEIILGNPV SLTADTWSIG VLTYVLLSGV 2880
SPFLDDSVEE TCLNICRLDF SFPDDYFKGV SQKAKDFVCF LLREDPATRP SAALSLQEHW 2940
LQAGHSKSAA TLDTSRLTSF IERRKHQNDV GPIRSIKNFL QSRL 2984
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60
         y++++e+gRGrFsvvkk+++k+tkrava+kfv+kk +k++qv++E+ iL++LqHpllv l
Q: 2687  YSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQNLQHPLLVGL  2746
         8999********************************************************
S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120
         +d++etp+s+vl+lE++++++LLd+++++++l+E ++++yl ++lea++YLHn+r++HLD
Q: 2747  LDTFETPTSYVLVLEMADQGRLLDCVVRWGNLTEGKIRMYLGEVLEAVRYLHNCRIAHLD  2806
         ************************************************************
S: 121   ikpenllv.laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatDi  179
         +kpen+lv ++ a++++k++D+g+A++l+++++++ llg+pEf aPEii g+pvs ++D+
Q: 2807  LKPENILVdQSSAKPTIKLADFGDAVQLNTTYYIHPLLGNPEFSAPEIILGNPVSLTADT  2866
         ********999*************************************************
S: 180   WavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqedp  239
         W++Gvl+yvlLsgvsPfld+s +et+lni+++++sf++++f+g+s++Ak+F++++L edp
Q: 2867  WSIGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKDFVCFLLREDP  2926
         ************************************************************
S: 240   rkRPsaaecLqhpWl  254
         ++RPsaa +Lq+ Wl
Q: 2927  ATRPSAALSLQEHWL  2941
         **************8
Domain Sequence
(FASTA)
YSEVAELGRG RFSVVKKCDQ KGTKRAVATK FVNKKLMKRD QVTHELGILQ NLQHPLLVGL 60
LDTFETPTSY VLVLEMADQG RLLDCVVRWG NLTEGKIRMY LGEVLEAVRY LHNCRIAHLD 120
LKPENILVDQ SSAKPTIKLA DFGDAVQLNT TYYIHPLLGN PEFSAPEIIL GNPVSLTADT 180
WSIGVLTYVL LSGVSPFLDD SVEETCLNIC RLDFSFPDDY FKGVSQKAKD FVCFLLREDP 240
ATRPSAALSL QEHWL 255
KeywordComplete proteome; Reference proteome; Repeat; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00015
EKS-BOT-00019
EKS-CAJ-00022
EKS-CAF-00020
EKS-CAP-00021
EKS-DAR-00026
EKS-EQC-00020
EKS-FEC-00019
EKS-GAG-00019
EKS-GAA-00031
EKS-GOG-00022
EKS-HOS-00020
EKS-ICT-00019
EKS-LAC-00021
EKS-MOD-00020
EKS-MUM-00021
EKS-MUP-00021
EKS-MYL-00022
EKS-NOL-00020
EKS-ORN-00028
EKS-ORA-00017
EKS-ORC-00020
EKS-ORL-00028
EKS-OTG-00021
EKS-PAT-00019
EKS-PES-00020
EKS-POA-00020
EKS-RAN-00021
EKS-SAH-00019
EKS-SUS-00019
EKS-TAG-00019
EKS-TAR-00031
EKS-TEN-00034
EKS-XET-00019
EKS-XIM-00030
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023; P:regulation of Rho protein signal transduction
KEGG
InterPros
IPR001251; CRAL-TRIO_dom.
IPR000219; DH-domain.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR018159; Spectrin/alpha-actinin.
IPR002017; Spectrin_repeat.
Pfam
PF07679; I-set; 1.
PF00069; Pkinase; 1.
PF00621; RhoGEF; 2.
PF00018; SH3_1; 1.
PF00435; Spectrin; 4.
SMARTs
SM00408; IGc2; 1.
SM00233; PH; 2.
SM00325; RhoGEF; 2.
SM00220; S_TKc; 1.
SM00516; SEC14; 1.
SM00326; SH3; 2.
SM00150; SPEC; 6.
Prosites
PS50191; CRAL_TRIO; 1.
PS50010; DH_2; 2.
PS50835; IG_LIKE; 1.
PS50003; PH_DOMAIN; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013