EKS-LOA-00291
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00291
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR431.71.6E-129204490287
StatusUnreviewed
Ensembl ProteinENSLAFP00000006720
UniProt AccessionG3T112;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000008019ENSLAFP00000006720ENSLAFT00000008018
OrganismLoxodonta africana
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MALGAPRRGL LLLLMALGLT QSDPVRPYRG PLVTCTCENP HCRGPTCQGA WCTVVLVREE 60
GRHPQEHRGC GNLHPELCNG RPTEFVNHYC CYSPLCNYNV SLVLEATRTP SEQPGVDGQL 120
PLVLGPVLAL LALVALGALG LWHVRRRQEK HRGLHSELGE SSIILKASEQ GDSMLGDLLD 180
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
LKLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360
DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIT RRTIINGIVE 420
DYRPPFYDAV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYTNPSAR 480
LTALRIKKTL QKLSNSPEEP KVIH 504
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 204   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +l+la s+a+GlahLH ei+gt+g
Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQG  323
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  381
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         l+e++ +++fe++k++D++++gLvlWE+++R+   +++ve+y++pf++ v++dPs+e+mk
Q: 382   LDEQIRTDCFESYKWTDIWAFGLVLWEITRRTII-NGIVEDYRPPFYDAVPNDPSFEDMK  440
         *********************************9.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+++p+aRltalr+kk+l
Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYTNPSARLTALRIKKTL  490
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALKL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLD 180
EQIRTDCFES YKWTDIWAFG LVLWEITRRT IINGIVEDYR PPFYDAVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YTNPSARLTA LRIKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013