EKS-LOA-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	315.9	2.3E-94	774	1029	256

Status

Unreviewed

Ensembl Protein

ENSLAFP00000007193

UniProt Accession

G3T227;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000008565	ENSLAFP00000007193	ENSLAFT00000008565

Organism

Loxodonta africana

Functional Description

Protein Length

1061

Protein Sequence
(FASTA)

DFHFRVYKWM FEAHMQNYRG DDPLGEWESY MQWVEENFPK NKEYLTTLLG HLMKEFLDKK 60

RYHNDPRFIS YCLKFAQYNS DLHQFYEFLY NHGIGTLSSP LYIAWAGHLE GQGELQHASA 120

VFRRGIQNQA EPRELLQHQY RLFQKRLAET HLGAQARTSE PLHDAQVVNQ TIISDSNPGK 180

NTGCVSENQG SQLSAVTSTT CGEESNMQRY RGQRVIVVSK SEYSTHSSLA AKTDVKQVVM 240

YCKEKLIRGE SEFSFEELRA QKYNQRRKHE QWVNEDRHYM RRKEASAFEE QLLKQKMDEL 300

HKKLHQVVEM SHEDLPAFQE RSEVNAVRMG PRVAPQEELR GSSLPATDQQ TSGNMREKPR 360

EASPVVPLVA NAVTTALAPP AVSQGAAHPL PVTAQPVADS ACESRSAHEF KPQSGAEIKE 420

ACEAPKLTNT NSFHTTPNTS LGAVQATPSK VQPSPTVHTK EALGFIMDMF QAPTLPDISD 480

DKDDWSSLDQ NEDAFEAQFQ KNTKSSGVWG VNKIISSLSS AFPVFEDGNK ENYGLPQPKN 540

KPAGARTFGE RSMSRLPAKR NEVPAHTDEF LDDSTVWGIR CDKTLAPVPK TTGDFTSAAQ 600

LASTPFHKLP VESANALEDK ENMVAQQCTR VTLDCGEENT VETSKTRKFS PRSDVPSAPV 660

LGQSQPAAGG VLTSEAERCL EACKLTDTDV AMEEDPPGAR PAGLHAERMQ SSSAGNVAAS 720

NFVVENPWDD TLILKLLSGL SKPVSTYPNT FEWQYKLPPI KPKTEFQLGS LVIYIDHLLG 780

EGAFAQVYEA AQDDANDAKS KQKFILKVQK PANPWEFYIG TQLMERLKPS MQHMFIKFYS 840

AHFFQNGSVL VGDLFSYGTL LNAINLYKNT PEKVMPQALV ISFAIRMLHM IEQVHDCEII 900

HGDVKPDNFI LGNRFLEQDG EDDDFSAGLV LIDLGTFAAK CETSGFQCVE MLSKKPWKGH 960

HIDYFGVAAT VYCMLFGTYM KVKNEGGAWK PEGLFRRLPH LDMWSEFFHI MLNIPDCHQL 1020

PSLDSLRQKL KKTFQQHYSN KIRTLRNRLI VLLLEYKRSR K 1061

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         +i++++geGa+a+vy+a +    d+ks+++++lKv+kpan+WefYI +ql+eRlk ++++

Q: 774   YIDHLLGEGAFAQVYEAAQddanDAKSKQKFILKVQKPANPWEFYIGTQLMERLK-PSMQ  832

         79****************99999999*****************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+ fq++s+lv ++ sygtll++in++k++ +kvm+++lv+++++++l+++e

Q: 833   HMFIKFYSAHFFQNGSVLVGDLFSYGTLLNAINLYKNTPEKVMPQALVISFAIRMLHMIE  892

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lgnr+ ++   +d+ ++gl liD+g            +f +k

Q: 893   QVHDCEIIHGDVKPDNFILGNRFLEQDGeDDDFSAGLVLIDLG------------TFAAK  940

         ************************998824555677*****99............6999*

S: 177   aktdafeciemlagksws.YqvDlfglaavihvllfgkyleviqeggswklkqkikrllk  235

         ++t++f+c+eml+ k+w+  ++D+fg+aa+++++lfg+y++v++egg wk++  ++rl++

Q: 941   CETSGFQCVEMLSKKPWKgHHIDYFGVAATVYCMLFGTYMKVKNEGGAWKPEGLFRRLPH  1000

         *****************7589***************************************

S: 236   kelwekiferlLNisdastlpsleelveek  265

          ++w ++f+ +LNi+d+++lpsl+ l++ k

Q: 1001  LDMWSEFFHIMLNIPDCHQLPSLDSLRQ-K  1029

         **************************95.4

Domain Sequence
(FASTA)

YIDHLLGEGA FAQVYEAAQD DANDAKSKQK FILKVQKPAN PWEFYIGTQL MERLKPSMQH 60

MFIKFYSAHF FQNGSVLVGD LFSYGTLLNA INLYKNTPEK VMPQALVISF AIRMLHMIEQ 120

VHDCEIIHGD VKPDNFILGN RFLEQDGEDD DFSAGLVLID LGTFAAKCET SGFQCVEMLS 180

KKPWKGHHID YFGVAATVYC MLFGTYMKVK NEGGAWKPEG LFRRLPHLDM WSEFFHIMLN 240

IPDCHQLPSL DSLRQK 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013