EKS-LOA-00116
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00116
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LRRK429.07.8E-12912431518276
StatusUnreviewed
Ensembl ProteinENSLAFP00000007346
UniProt AccessionG3T2F4;
Protein Name
Protein Synonyms/Alias
Gene NameLRRK1
Gene Synonyms/Alias LRRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000008742ENSLAFP00000007346ENSLAFT00000008745
OrganismLoxodonta africana
Functional Description
Protein Length2015
Protein Sequence
(FASTA)
MAGMSRQPPS MYWCVGPEGS AMYPERTMET HNGAGGMGSK PSTPGGDCTV PSPQTEGIYT 60
AYKQNNPSRA RDLIREACDE STSQQEKGQL LSISAAYGDL ETVRYLLAQR QVELPTEPTD 120
DNPAVVAARF GHTAVVQELL ESLSGPCSPR RLLNWMLALA CQQGHLGVVK LLVLTHGADP 180
ESYAVRKNEF PAITRLPLYA AIKSGNEDVA IFLLRHGAFF CSYILLDSPD TSKHLLRKYF 240
METSALPSGC PGKAALRVKW SHLKLPWVDL DWLIDISCQI TELDLSANCL ASLPSVIPWG 300
LINLRKLNLA DNHLGELPGV QSSDEIICSR LLEIDISGNK LFHLPPGFLH LSKLQKLTAS 360
KNYLEKLFEE ENATNWIGLR KLQELDVSDN KLTELPALFL HSFKSLTFLN VSRNNLKAFP 420
DPWACPLKCC KTSRNALEFL PDKMAIFWKN HLKDVDFSEN ALKEVPLGLF QLDALMFLRL 480
QGNQLGALPP QDKWTCRQLK TLDLSRNQLG KSEDGLKTKR ISFFTTRGRQ RSGTETGCVL 540
EFPAFLSESL EVLCLNDNHL DAVPPSVCLL KNLSELYLGN NPGLRELPQE LGQLGNLWQL 600
DVEDLHITNV PAEIQKEGPK AMLSYLRAQL RKAERCKLMK MIIVGPPRQG KSTLLEILQT 660
GRAPQVVHGE ATIRTTKWEL QRPAGSRAKV ESVEFNVWDI GGPASMATVN QCFFTDKALY 720
VVVWNLALGE EAVASLQFWL LNIEAKAPNA VVLVVGTHLD LIETKFRVER IATLRAYVLA 780
LCRSPSGARA TGFPDITNRH LHELSCKSLE GQEGLRQLIF HVTCSMKDVG SPIGCQRLAG 840
RLVPKSYLSL QEAVLAEQQQ RSQSDAVQYL TDRQLEQLVE QTPGNDIKDY EDLQSAISFL 900
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIRGS RSVAKNGVIR TEDLRMLLVG 960
TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG LDTHSMRHPT ANTIKRVFKM 1020
SFVPVGFWQR FIARMLISLA EMDLQLFENK KNTKSRSRRV TIYSFTGNQR NRCSTFRVKR 1080
NHTIYWQEGL LVTFDGGDLS VESSDVNWKK KKSGGIKIIC QSEMRDFSAM AFITDHVNSL 1140
IDQWFPALTA TESDGTPLME QYVPCPVCEA SWARCAAHTE KAEGVHYFDM EDCVLTAIEQ 1200
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH SEDESSILGQ GGSGTVIYRA 1260
QYQGQPVAVK RFQIKKFKNF ANVPADTMLR HLRATDAMKN FSEFRQEASM LHALQHPCIV 1320
SLIGISIHPL GFALELAPLG SLNTVLSENA KDSSFMPLGH MLTQKIAYQI ASGLAYLHKK 1380
NIIFCDLKSD NILVWSLDVK EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEVRPRIV 1440
YDEKVDMFSY GMVLYELLSG QRPALGHHQL QISKKLSKGI RPVLGQPEEV QFHRLQALMM 1500
ECWDTKPEKR PLAVSVVSQM KDPTFAAFMY LLPCGKQTSF FSSQGQEYTV VFWDGKEETR 1560
NYTVVNTEKG LLEVQRMSCA GMRLSCQLKV QSSLWTATED QKIYIYSLKG MCPLNIPQRA 1620
LDTPAVVTCF LAVPVIKKNS YLVLAGLSDG LVAVFPVTRG APGDSFCYLC SHTANRSKFS 1680
ISDEDARQNP YPVKAMEVVN SGSEVWYSNG PGLLVIDCTA LEIRRRLEPY SAPSVVTSIV 1740
CSSECRGEEV VWCLDDKANS LVMYHSATYQ LCARYFCGDP NPLRDMFPVR PAGPDSPGCP 1800
AAGPQELEGD GLADVSIIYS KELGTQILAH QDSLTDYCSM SSYSSSPPRR AAWSPASLPS 1860
SPVSSSSVPV SSTDYEDLDQ PHEPGACSDR SEQELSPVDG DAFSQHLQAV KILAVRDLIW 1920
VPRRGGDVII IGLEKESGAQ RGRVIAVLKA RELNPHGVLV DAAVVAKDTV VCGFENENSE 1980
WCLAVWRAWG AREFDIFYQS YEELGRLENY TRKRR 2015
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 2     kkgsllGrGafGsv.yraavkGeevavkafki..........aadklkrdslelalkays  50
         +++s+lG+G++G+v yra+++G++vavk+f+i          a+++l+++++++a+k++s
Q: 1243  DESSILGQGGSGTViYRAQYQGQPVAVKRFQIkkfknfanvpADTMLRHLRATDAMKNFS  1302
         689*********************************************************
S: 51    elrqelsvLlalkhPsivsLvgisikPlalvleLaplgsLdrlLsedkksss..klgrtl  108
         e+rqe+s+L+al+hP+ivsL+gisi+Pl ++leLaplgsL+++Lse++k+ss  +lg++l
Q: 1303  EFRQEASMLHALQHPCIVSLIGISIHPLGFALELAPLGSLNTVLSENAKDSSfmPLGHML  1362
         ***************************************************9999*****
S: 109   tkkialqvargleyLhkkkiiyrdLksenvLvwslspkeailikladyGisrqslrsGak  168
         t+kia+q+a+gl+yLhkk+ii++dLks+n+Lvwsl++ke+i+ikl+dyGisrqs+++Ga+
Q: 1363  TQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGAL  1422
         ************************************************************
S: 169   gveGteGfraPeivrgevvydekvdvfsfGlllyellsgkrpvegeeqlkivekllkGkr  228
         gveGt+G++aPe+ r+++vydekvd+fs+G++lyellsg+rp++g++ql+i +kl+kG+r
Q: 1423  GVEGTPGYQAPEV-RPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQISKKLSKGIR  1481
         *************.**********************************************
S: 229   PvlvkeeevlptplldLlveCwkekPekrPtasqvvs  265
         Pvl+++eev++++l++L++eCw++kPekrP+a +vvs
Q: 1482  PVLGQPEEVQFHRLQALMMECWDTKPEKRPLAVSVVS  1518
         ***********************************97
Domain Sequence
(FASTA)
DESSILGQGG SGTVIYRAQY QGQPVAVKRF QIKKFKNFAN VPADTMLRHL RATDAMKNFS 60
EFRQEASMLH ALQHPCIVSL IGISIHPLGF ALELAPLGSL NTVLSENAKD SSFMPLGHML 120
TQKIAYQIAS GLAYLHKKNI IFCDLKSDNI LVWSLDVKEH INIKLSDYGI SRQSFHEGAL 180
GVEGTPGYQA PEVRPRIVYD EKVDMFSYGM VLYELLSGQR PALGHHQLQI SKKLSKGIRP 240
VLGQPEEVQF HRLQALMMEC WDTKPEKRPL AVSVVS 276
KeywordATP-binding; Complete proteome; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00113
EKS-ANC-00109
EKS-BOT-00121
EKS-CAE-00098
EKS-CAJ-00123
EKS-CAF-00124
EKS-CAP-00118
EKS-DAR-00378
EKS-DRM-00059
EKS-EQC-00117
EKS-FEC-00112
EKS-GAG-00101
EKS-GAA-00140
EKS-GOG-00120
EKS-HOS-00123
EKS-ICT-00114
EKS-LAC-00126
EKS-MAM-00117
EKS-MEG-00091
EKS-MOD-00118
EKS-MUM-00122
EKS-MUP-00124
EKS-MYL-00132
EKS-NOL-00113
EKS-ORN-00148
EKS-ORA-00099
EKS-ORC-00113
EKS-OTG-00124
EKS-PAT-00110
EKS-PES-00104
EKS-PEM-00066
EKS-POA-00114
EKS-RAN-00118
EKS-SAH-00113
EKS-SUS-00107
EKS-TAG-00150
EKS-TAR-00153
EKS-TEN-00140
EKS-XET-00100
EKS-XIM-00145
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004672; F:protein kinase activity
GO:0007264; P:small GTPase mediated signal transduction
KEGG
InterPros
IPR002110; Ankyrin_rpt.
IPR020683; Ankyrin_rpt-contain_dom.
IPR011009; Kinase-like_dom.
IPR001611; Leu-rich_rpt.
IPR025875; Leu-rich_rpt_4.
IPR003591; Leu-rich_rpt_typical-subtyp.
IPR013684; MIRO-like.
IPR000719; Prot_kinase_cat_dom.
IPR020859; ROC_GTPase.
IPR017986; WD40_repeat_dom.
Pfam
PF12796; Ank_2; 1.
PF12799; LRR_4; 1.
PF08477; Miro; 1.
PF00069; Pkinase; 1.
SMARTs
SM00248; ANK; 3.
SM00369; LRR_TYP; 1.
Prosites
PS50297; ANK_REP_REGION; 1.
PS51450; LRR; 11.
PS50011; PROTEIN_KINASE_DOM; 1.
PS51424; ROC; 1.
Prints
Created Date20-Feb-2013