EKS-LOA-00058
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00058
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK401.42.4E-1204286283
StatusUnreviewed
Ensembl ProteinENSLAFP00000007380
UniProt AccessionG3T2I2;
Protein Name
Protein Synonyms/Alias
Gene NameCDK5
Gene Synonyms/Alias CDK5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000008785ENSLAFP00000007380ENSLAFT00000008785
OrganismLoxodonta africana
Functional Description
Protein Length292
Protein Sequence
(FASTA)
MQKYKKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 120
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP 240
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 292
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         y+klekigeGtyg+v+kak++et+e+vAlK++rl++++egvp++alrEi llkelkhkni
Q: 4     YKKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI  63
         89**********************************************************
S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120
         v+L++v++ ++kkl+Lvfef++qdLkk++++++  +l++e vks+l+qll+gl ++Hs++
Q: 64    VRLHDVLH-SDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRN  121
         ********.99***********************.*************************
S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180
         +lHRDlKpqNlLi+++g+lklaDfGlaraf+ p++ y+ evvTlwYr+P++L+gak Yst
Q: 122   VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST  181
         ************************************************************
S: 181   avDiWsvgcilaellt.rkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239
         ++D+Ws+gci+ael++  +plf+g++  dql+rif+llgtp+e++wp ++klp+yk  +p
Q: 182   SIDMWSAGCIFAELANaGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK-PYP  240
         **************97369*************************************.555
S: 240   kkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284
          ++++ +l ++v+kl+ +++dll++ll+++p +Risa+ealqh+yf
Q: 241   MYPATtSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF  286
         5555559**************************************9
Domain Sequence
(FASTA)
YKKLEKIGEG TYGTVFKAKN RETHEIVALK RVRLDDDDEG VPSSALREIC LLKELKHKNI 60
VRLHDVLHSD KKLTLVFEFC DQDLKKYFDS CNGDLDPEIV KSFLFQLLKG LGFCHSRNVL 120
HRDLKPQNLL INRNGELKLA DFGLARAFGI PVRCYSAEVV TLWYRPPDVL FGAKLYSTSI 180
DMWSAGCIFA ELANAGRPLF PGNDVDDQLK RIFRLLGTPT EEQWPAMTKL PDYKPYPMYP 240
ATTSLVNVVP KLNATGRDLL QNLLKCNPVQ RISAEEALQH PYF 283
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00053
EKS-BOT-00059
EKS-CAE-00041
EKS-CAJ-00055
EKS-CAF-00060
EKS-CAP-00057
EKS-CII-00021
EKS-CIS-00065
EKS-DAR-00072
EKS-DIO-00033
EKS-DRM-00024
EKS-EQC-00060
EKS-FEC-00056
EKS-GAM-00026
EKS-GAA-00075
EKS-GOG-00057
EKS-HOS-00059
EKS-ICT-00055
EKS-LAC-00064
EKS-MAM-00058
EKS-MIM-00029
EKS-MOD-00063
EKS-MUM-00058
EKS-MUP-00061
EKS-MYL-00060
EKS-NOL-00055
EKS-OCP-00040
EKS-ORN-00077
EKS-ORC-00056
EKS-ORL-00070
EKS-OTG-00062
EKS-PAT-00054
EKS-POA-00055
EKS-RAN-00056
EKS-SAH-00055
EKS-SUS-00052
EKS-TAR-00078
EKS-TEN-00095
EKS-TUB-00035
EKS-TUT-00057
EKS-XET-00071
EKS-XIM-00075
Gene Ontology
GO:0030424; C:axon
GO:0005829; C:cytosol
GO:0030175; C:filopodium
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0030549; F:acetylcholine receptor activator activity
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0048148; P:behavioral response to cocaine
GO:0070509; P:calcium ion import
GO:0007160; P:cell-matrix adhesion
GO:0021954; P:central nervous system neuron development
GO:0021697; P:cerebellar cortex formation
GO:0022038; P:corpus callosum development
GO:0048813; P:dendrite morphogenesis
GO:0021766; P:hippocampus development
GO:0006886; P:intracellular protein transport
GO:0021819; P:layer formation in cerebral cortex
GO:0008045; P:motor neuron axon guidance
GO:0045786; P:negative regulation of cell cycle
GO:0046826; P:negative regulation of protein export from nucleus
GO:0031397; P:negative regulation of protein ubiquitination
GO:0031914; P:negative regulation of synaptic plasticity
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0051402; P:neuron apoptotic process
GO:0001764; P:neuron migration
GO:0048709; P:oligodendrocyte differentiation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis
GO:0032092; P:positive regulation of protein binding
GO:0045860; P:positive regulation of protein kinase activity
GO:0090314; P:positive regulation of protein targeting to membrane
GO:0035418; P:protein localization to synapse
GO:0032801; P:receptor catabolic process
GO:0043113; P:receptor clustering
GO:0030334; P:regulation of cell migration
GO:0061001; P:regulation of dendritic spine morphogenesis
GO:0060079; P:regulation of excitatory postsynaptic membrane potential
GO:0014044; P:Schwann cell development
GO:0019233; P:sensory perception of pain
GO:0033136; P:serine phosphorylation of STAT3 protein
GO:0007519; P:skeletal muscle tissue development
GO:0007416; P:synapse assembly
GO:0001963; P:synaptic transmission, dopaminergic
GO:0035249; P:synaptic transmission, glutamatergic
GO:0008542; P:visual learning
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013