EKS-LOA-00163
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00163
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb427.81.8E-128415674260
StatusUnreviewed
Ensembl ProteinENSLAFP00000007489
UniProt AccessionG3T2S4;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000008921ENSLAFP00000007489ENSLAFT00000008922
OrganismLoxodonta africana
Functional Description
Protein Length771
Protein Sequence
(FASTA)
MGDEDEDESC AVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QHFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHVVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWTALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPSGSPPP GDPRVFQGYS 360
FVAPSILFDH NNAVMTDVLE APGPGDRPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEANT QREVTALRLC QSHPNVVKLH EVHQDQLHTY 480
LVLELLRGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
ESPEAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGLGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPT 660
KRLKLEGLRA SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAA SRRGSPAPAV PGRVPAAKGP SRRANGPLPP S 771
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVTALRLCQSHPNVVKLHEVHQ  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+des++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADESPEAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    + g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGLGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************98766789************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+krlkle+l+ +swl
Q: 654   LLTVDPTKRLKLEGLRASSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV TALRLCQSHP NVVKLHEVHQ 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADESPE APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG LGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPTKRLK LEGLRASSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DRM-00077
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
EKS-XIM-00199
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013