EKS-LOA-00149
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00149
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR500.51.2E-150500776277
StatusUnreviewed
Ensembl ProteinENSLAFP00000029245
UniProt AccessionG3UN36;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000009269ENSLAFP00000029245ENSLAFT00000034981
ENSLAFG00000009269ENSLAFP00000007768ENSLAFT00000009269
OrganismLoxodonta africana
Functional Description
Protein Length840
Protein Sequence
(FASTA)
MGLTSTWRYG RGLGIGTVTM VSWARFICLV VVTMATLSLA RPSFSLVEDT TLEPEEPPTK 60
YQISQPEVYV ATPGESLELG CLLKDAAMIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120
SGLYACTAAR SVDSETLYFM VNVTDAISSG DDEDDTDGSE DFVSENSNNK RAPYWTNTEK 180
MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240
VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT 360
CLAGNSIGIS FHSAWLTVLP APVREKDITA SPDYLEIAIY CIGVFLIACM VVTVILCRMK 420
TTTKKPDFSS QPAVHKLTKR IPLRRQTKVS AESSSSMNSN TPLVRITTRL SSTADTPMLA 480
GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKEKPKEA VTVAVKMLKD 540
DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLF VIVEYASKGN LREYLRARRP 600
PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK 660
IADFGLARDI NNIDYYKKTT NVSLCWKCLS PQGLIFQRYA DNTLSWSFGV LMWEIFTLGG 720
SPYPGIPVEE LFKLLKEGHR MDKPANCTSE LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL 780
TLTTNEDYLD LTQPLEQYSP SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHINGSVKT 840
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dk+k+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 500   LTLGKPLGEGCFGQVVMAEAVGIDKEKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  559
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gpl+viveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 560   IGKHKNIINLLGACTQDGPLFVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  619
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 620   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  679
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tn  l  k ++p+ l  + y  ++  wsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 680   TNVSLCWKCLSPQGLIFQRYADNTLSWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  739
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 740   RMDKPANCTSELYMMMRDCWHAVPSQRPTFKQLVEDL  776
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL FVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNVSLCWKCL SPQGLIFQRY ADNTLSWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTS ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-DAR-00432
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORA-00130
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0007409; P:axonogenesis
GO:0030282; P:bone mineralization
GO:0060349; P:bone morphogenesis
GO:0060667; P:branch elongation involved in salivary gland morphogenesis
GO:0060670; P:branching involved in labyrinthine layer morphogenesis
GO:0048755; P:branching morphogenesis of a nerve
GO:0060449; P:bud elongation involved in lung branching
GO:0045165; P:cell fate commitment
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0061031; P:endodermal digestive tract morphogenesis
GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069; P:hair follicle morphogenesis
GO:0032808; P:lacrimal gland development
GO:0060601; P:lateral sprouting from an epithelium
GO:0070307; P:lens fiber cell development
GO:0060174; P:limb bud formation
GO:0048286; P:lung alveolus development
GO:0060463; P:lung lobe morphogenesis
GO:0060484; P:lung-associated mesenchyme development
GO:0060615; P:mammary gland bud formation
GO:0003149; P:membranous septum morphogenesis
GO:0060915; P:mesenchymal cell differentiation involved in lung development
GO:0060916; P:mesenchymal cell proliferation involved in lung development
GO:0030901; P:midbrain development
GO:0035264; P:multicellular organism growth
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528; P:neuromuscular junction development
GO:0042476; P:odontogenesis
GO:0035265; P:organ growth
GO:0030916; P:otic vesicle formation
GO:0003148; P:outflow tract septum morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791; P:post-embryonic development
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523; P:prostate epithelial cord elongation
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489; P:synaptic vesicle transport
GO:0001657; P:ureteric bud development
GO:0055010; P:ventricular cardiac muscle tissue morphogenesis
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013