EKS-LOA-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	477.9	8.7E-144	14	275	262

Status

Unreviewed

Ensembl Protein

ENSLAFP00000008366

UniProt Accession

G3TQ37;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000009987	ENSLAFP00000008366	ENSLAFT00000009988
ENSLAFG00000009987	ENSLAFP00000017622	ENSLAFT00000022391

Organism

Loxodonta africana

Functional Description

Protein Length

1430

Protein Sequence
(FASTA)

MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED 60

IEREVSILKE VQHPNVITLH EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL 120

KQILNGVYYL HSLQIAHFDL KPENIMLLDR HVPKPRIKII DFGLAHKIDF GNEFKNIFGT 180

PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEEEY 240

FSNTSALAKD FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA 300

ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 360

QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK RGSRIDIQDK GGSNAIYWAS 420

RHGHVDTLKF LNENKCPLDV KDKSGETALH VAARYGHADV VQLLCSFGSN PNIQDKEEET 480

PLHCAAWHGY YSVAKALCEA GCNVNIKNRE GETPLLTASA RGYHDIVECL ADHGADLDAS 540

DKDGHIALHL AVRRCQMEVI KTLLGQGCFV DFQDRHGNTP LHVACKDGNM PIVVALCDAN 600

CNLDISNKYG RTPLHLAANN GILDVVRYLC LTGANVEALT SDGKTAEDLA KSEQHQHVAG 660

LLARLRKDTH RGLFIQQLRP TQNLQPRIKL KLFGHSGSGK TTLVESLKCG LLRSFFRRRR 720

PRLSSTNSTR FPPSPLASKP TVSVSTNNLY PGCENVSVRS RSMMFEPGLT KGMLEVFVAP 780

PPHPHCSADD QATKAIDIQN AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSVHIIVF 840

SLEEPYEIQL NQVIFWLSFL KSLVPVEEPI AFGGKLKNPL RVVLVATHAD IMNVPRPAGG 900

EFGYDKDTSL LKEIRNRFGN DLHISNKLFV LDAGASGSKD MKVLRNHLQE IRSQIVSVCP 960

PMTHLCEKII STLPSWRKLG GPNQLMSLQQ FMYDVQDQLN PLASEEDLRH MAQQLHSIGE 1020

INIMQSETVQ DVLLLDPRWL CTTVLGKLLS VETPRALHHY RGRYTVEDIQ RLVPDSDVEE 1080

LLQILDAMDI CARDLSSGTM VDIPALIKTD NLHRSWTDEE DEVMVYGGVR VVPVEHLTPF 1140

PCGIFHKVQV NLCRWIHQQS AEGDADIRLW VNGCKIANRG AELLVLLVNH GQGIEVQVRG 1200

LETEKIKCCL LLDSVCSTIE NVMATTLPGL LTVKHYLSPQ QLREHHEPVM IYQPRDFFRA 1260

QTLKEASLTN TMGGYKESFS SIMCFGCHDV YSQASLGMDI HASDLNLLTR RKLSRLLDPP 1320

DPMGKDWCLL AMNLGLPDLV AKYNTNNGSS KDFLPSPVHA LLREWTTYPE STVGILMSKL 1380

RELGRRDAAD FLLKASSVFK INLDVNGQEA YASSCNSGTS YNSISSVVSR 1430

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         +tg+elgsG+favv+kcrekstG +yaakf+kkrr+kssrrgvsre+ierev++lke++

Q: 14    DTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEVQ-  72

         789********************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         +pnvi+lhevyenk+dvililelvaGGelfd+laekesl+eeeate+lkqil+gv+ylhs

Q: 73    HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS  132

         ************************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

          +i+h+dlkPeni+lld++vpk++ik+idfGl++ki+ g+e+k+i+GtPefvaPeivnye

Q: 133   LQIAHFDLKPENIMLLDRHVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE  192

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmwsiGvityillsgasPflGdtkqetl+n+savn++f+ee+fs++s lakdfi

Q: 193   PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEEEYFSNTSALAKDFI  252

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

         rrllvkdp+kr+ti+++l+h+w+

Q: 253   RRLLVKDPKKRMTIQDSLQHPWI  275

         **********************8

Domain Sequence
(FASTA)

DTGEELGSGQ FAVVKKCREK STGLQYAAKF IKKRRTKSSR RGVSREDIER EVSILKEVQH 60

PNVITLHEVY ENKTDVILIL ELVAGGELFD FLAEKESLTE EEATEFLKQI LNGVYYLHSL 120

QIAHFDLKPE NIMLLDRHVP KPRIKIIDFG LAHKIDFGNE FKNIFGTPEF VAPEIVNYEP 180

LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANVSAVN YEFEEEYFSN TSALAKDFIR 240

RLLVKDPKKR MTIQDSLQHP WI 262

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000310	; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12796	; Ank_2; 3.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS50017	; DEATH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013