EKS-LOA-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	390.2	6.6E-117	564	828	265

Status

Unreviewed

Ensembl Protein

ENSLAFP00000009252

UniProt Accession

G3T6S6;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR1

Gene Synonyms/Alias

KSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000011057	ENSLAFP00000009252	ENSLAFT00000011057
ENSLAFG00000011057	ENSLAFP00000024901	ENSLAFT00000029287

Organism

Loxodonta africana

Functional Description

Protein Length

874

Protein Sequence
(FASTA)

MDKAALRAAA MGETEGGGGG DAAAADGGAE AAASRALQQC GQLQKLIDIS IGSLRGLRTK 60

CAVSNDLTQQ EIRTLEAKLV RYICKQRQCK LSVAPGERTS ELNSYPRFSD WLYTFNVRPE 120

VVQEIPSELT LDALLDMNEA KVKETLRRCG ASTEECGRLQ HALTCLRKVT GRGGEHKEDS 180

GWSPLDARRE SGSGPSTDTT QLGRMGSSAQ GPRSISVSAL PASDSLTPGP SEGLVDTCIP 240

LHASGRLTPR ALHSFITPPT TPQLRRHTKL KPPRTPPPPS RKVFQLLPSF PTLTRSKSHE 300

SQLGNRIDEV SSMSLDLPHG SPQMVRRDIG LSVTHRFSTK SWLSQVCHVC QKSMMFGVKC 360

KHCRLKCHNK CTKEAPACRI SFLPLPRLRR TESVPSDINN PVDRAAEPHF GTLPKALTKK 420

EHPPAMSHLD SSSTPSSTTS STPSSPAPFP TSSNPSSATT PPNPSPGQRD SRFNFPVESP 480

CLPASPLAAF TVLPVLNDQP KADVLEDHEA EAEEPEAGKS EAEDDEDEVD DLPSSRRTWR 540

GPISRKASQT SVYLQEWDIP FEQVELGEPI GQGRWGRVHR GRWHGEVAIR LLEMDGNNQD 600

HLKLFKKEVM NYRQTRHENV VLFMGACMNP PHLAIITSFC KGRTLHSFVR DPKTSLDINK 660

TRQIAQEIIK GMGYLHAKGI VHKDLKSKNV FYDNGKVVIT DFGLFGISGM VREGRRENQL 720

KLSHDWLCYL APEIVREMTP GKDEDKLPFS KAADVYAFGT IWYELQARDW PFKNQAAEAL 780

IWQIGSGEGM KRILASVSLG KEVSEILSAC WAFDLQERPS FPLLMDMLEK LPKLNRRLSH 840

PGHFWKSADI NSSKVVPRFE RFGLGVLESS NPKM 874

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60

         vel+e iG+Gr+G+v+rg+whG+va++ll+++ +++++l+ Fkkev++y++tRhen+vLF

Q: 564   VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGNNQDHLKLFKKEVMNYRQTRHENVVLF  623

         67899*******************************************************

S: 61    mG.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhk  119

         mG ++++p+lai+ts+ckg++L++++++ +t+ld++k+++ia++i++gm+YLhak+i+hk

Q: 624   MGaCMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHK  683

         ************************************************************

S: 120   DlksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidl  178

         Dlkskn+++++g kvvitDFgl+ ++ ++++ rre+ql+++++w++ylape++r++++++

Q: 684   DLKSKNVFYDNG-KVVITDFGLFGISGMVREgRRENQLKLSHDWLCYLAPEIVREMTPGK  742

         ************.**************99977****************************

S: 179   eqdelpfskesDvyafGivlyellarelpykeesadqilfavgrG..lkpdlskvksklp  236

         ++d+lpfsk++DvyafG+++yel+ar++p+k+++a++ ++++g+G  +k+ l++v  +l+

Q: 743   DEDKLPFSKAADVYAFGTIWYELQARDWPFKNQAAEALIWQIGSGegMKRILASV--SLG  800

         ******************************************99988********..***

S: 237   kelkellleClkfekeeRPlftqilkkl  264

         ke++e+l++C++f+ +eRP+f+ ++++l

Q: 801   KEVSEILSACWAFDLQERPSFPLLMDML  828

         ************************9985

Domain Sequence
(FASTA)

VELGEPIGQG RWGRVHRGRW HGEVAIRLLE MDGNNQDHLK LFKKEVMNYR QTRHENVVLF 60

MGACMNPPHL AIITSFCKGR TLHSFVRDPK TSLDINKTRQ IAQEIIKGMG YLHAKGIVHK 120

DLKSKNVFYD NGKVVITDFG LFGISGMVRE GRRENQLKLS HDWLCYLAPE IVREMTPGKD 180

EDKLPFSKAA DVYAFGTIWY ELQARDWPFK NQAAEALIWQ IGSGEGMKRI LASVSLGKEV 240

SEILSACWAF DLQERPSFPL LMDML 265

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0043410	; P:positive regulation of MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013