EKS-LOA-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.5	3.1E-111	729	1022	294

Status

Unreviewed

Ensembl Protein

ENSLAFP00000009568

UniProt Accession

G3T7I2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000011451	ENSLAFP00000009568	ENSLAFT00000011453

Organism

Loxodonta africana

Functional Description

Protein Length

1493

Protein Sequence
(FASTA)

MPNSERHGGK KDGGGGASGT LQPSSGGGSS NSRERHRLLS KHKRHKSKHS KDMGLVTPEA 60

APLGTIIKPL VEYDDISSDS DTFSDDMAFK LERRENDERR GTDRSDRLHK HRHHQHRRSR 120

DLVKTKQTEK EKNQDVSSKS GSMKDRISGS SKRSNEENDD YGKTQPSKSS SNKESRSSKL 180

HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SPKQDDSPSG 240

ASYSQDYDLS PPRSHTSSNY DSYKKSPGST SRRQSISPPY KEPSAYQSST RSPSPYSRRQ 300

RSVSPYSRRR SSSYERSGSY SGRSPSPYGR RRSSSPFMSK RSLSRSPLPS RKSMKSRSRS 360

PAYSRHSSSH SKKKRSGSRS RHSSISPVRL PLNSSLGAEL SRKKKERAAA AAAAKADGKE 420

SKGSPIFLPK KENSSVEAKD SGLESKKLPR VVKLEKPAPD TELVNVTHLN TEVKNSLDTG 480

KVKLDENSEK HPILKDLKAQ GTKDSKPIAS KEEIVTPKET ETSEKETLPP LPTITSPPPP 540

LPTTTPPPQT PPLPPLPPLP ATPQQPPLPP PQPAFSQVLA SSTSTLPPST HPRTSTLSSQ 600

TNSQPSVQVS VKTQVSVTAA IPHLKTSTLP PLPLPPLLPG DDDMDSPKET LPSKPVKKEK 660

EQRTRHSLMD LPLPPELPGG DPSPPDSPEP KAITPPQQSY KKRPKICCPR YGERRQTESD 720

WGKRCVDKFD IIGIIGEGTY GQVYKAKDKD TGELVALKKV RLDNEKEGFP ITAIREIKIL 780

RQLIHRSVVN MKEIVTDKQD ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VHFSEDHIKS 840

FMKQLMEGLD YCHKKNFLHR DIKCSNILLN NSGQIKLADF GLARLYNSEE SRPYTNKVIT 900

LWYRPPELLL GEERYTPAID VWSCGCILGE LFTKKPIFQA NLELAQLELI SRLCGSPCPA 960

VWPDVIKLPY FNTMKPKKQY RRRLREEFSF IPSAALDLLD HMLTLDPSKR CTAEQTLQSD 1020

FLKDVELSKM APPDLPHWQD CHELWSKKRR RQRQSGVAVE EPPPPKAPRK ETTSGTSAEP 1080

VKNNSPVPPP QPAPGKVEPG AGDAVGLGDI TQQLNQSELA VLLNLLQSQT DLSIPQMAQL 1140

LNIHSNPEMQ QQLEALNQSI SALTEATSQQ QDSEPMAPEE SLKDAPPAPV VQPSTEQTAP 1200

EVSSTPADMQ NMLAVLLSQL MKTQEPAGSL EENNGDKNSG PQGLRRTPTM SQEEAAACPP 1260

HILPPEKRPP EPPGPPPPPP PPPLVEGDLS SAPQELNPAV TAALLQLLSQ PEAEPPGHLP 1320

HEHQALRPME YSTRPPPNRT YGNTDGPETG FSATDTDERN SGPALTESLA QTLVKNRTFS 1380

GSVSHLGESS SYQGTGSVQF PGDQDLRFAR VPLALHSVVG QPFLKAEGSS NSVVRAETKL 1440

QNYGELGPGT TGASSSGAGL NWGAPAQASA YGKLYRAPTR VPPRGGRGRG VPY 1493

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 729   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  788

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 789   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  847

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 848   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  907

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 908   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  967

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 968   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1022

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777	; P:protein autophosphorylation
GO:0043405	; P:regulation of MAP kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013