EKS-LOA-00050
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00050
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF413.94.0E-124349606258
StatusUnreviewed
Ensembl ProteinENSLAFP00000009699
UniProt AccessionG3T7U2;
Protein Name
Protein Synonyms/Alias
Gene NameRAF1
Gene Synonyms/Alias RAF1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000011608ENSLAFP00000009699ENSLAFT00000011607
OrganismLoxodonta africana
Functional Description
Protein Length648
Protein Sequence
(FASTA)
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV 60
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 120
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180
PTMCVDWSNI RQLLLFPNST VGDSGVPALP SLTMRRMRES VSRMPASSQH RYSTPHAFTF 240
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRVIEDA IRSHSESASP SALSSSPNNL 300
SPTGWPQPKT PVPAQRERAP GPGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360
GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 600
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 648
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l+++iGsG+fGtvy+gkwhGdvavk+l+v ++++eql+aF++eva+++ktRh+ni+LF
Q: 349   VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLF  408
         57899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mGy++k++laivt++c+gssLyk+lh+qetk+++ +lidiarq+aqgmdYLhak+i+h+D
Q: 409   MGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD  468
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         +ks+ni+l+egl+v+i+DFgl++vk+++sg  ++q+e+p+g++l++apevir+      q
Q: 469   MKSNNIFLHEGLTVKIGDFGLATVKSRWSG--SQQVEQPTGSVLWMAPEVIRM------Q  520
         ******************************..*********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d++pfs++sDvy++Givlyel+++elpy++ +++dqi+f+vgrG ++pdlsk+++++pk+
Q: 521   DNNPFSFQSDVYSYGIVLYELMTGELPYSHiNNRDQIIFMVGRGyASPDLSKLYKNCPKA  580
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +k+l+++C+k+ keeRPlf+qil+++
Q: 581   MKRLVADCVKKVKEERPLFPQILSSI  606
         **********************9875
Domain Sequence
(FASTA)
VMLSTRIGSG SFGTVYKGKW HGDVAVKILK VVDPTPEQLQ AFRNEVAVLR KTRHVNILLF 60
MGYMTKDNLA IVTQWCEGSS LYKHLHVQET KFQMFQLIDI ARQTAQGMDY LHAKNIIHRD 120
MKSNNIFLHE GLTVKIGDFG LATVKSRWSG SQQVEQPTGS VLWMAPEVIR MQDNNPFSFQ 180
SDVYSYGIVL YELMTGELPY SHINNRDQII FMVGRGYASP DLSKLYKNCP KAMKRLVADC 240
VKKVKEERPL FPQILSSI 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00047
EKS-ANC-00042
EKS-CAE-00039
EKS-CAJ-00050
EKS-CAF-00051
EKS-CAP-00051
EKS-DAR-00066
EKS-DRM-00019
EKS-EQC-00049
EKS-FEC-00049
EKS-GAG-00042
EKS-GAA-00068
EKS-GOG-00050
EKS-HOS-00051
EKS-ICT-00048
EKS-LAC-00054
EKS-MAM-00049
EKS-MEG-00040
EKS-MOD-00049
EKS-MUM-00051
EKS-MUP-00053
EKS-MYL-00053
EKS-NOL-00049
EKS-OCP-00036
EKS-ORN-00070
EKS-ORC-00047
EKS-ORL-00067
EKS-OTG-00054
EKS-PAT-00047
EKS-PES-00046
EKS-POA-00048
EKS-PRC-00035
EKS-RAN-00050
EKS-SAH-00048
EKS-SUS-00047
EKS-TAG-00047
EKS-TAR-00071
EKS-TEN-00074
EKS-XET-00052
EKS-XIM-00068
Gene Ontology
GO:0005622; C:intracellular
GO:0031143; C:pseudopodium
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0006915; P:apoptotic process
GO:0007010; P:cytoskeleton organization
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0031333; P:negative regulation of protein complex assembly
GO:0048011; P:nerve growth factor receptor signaling pathway
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013