EKS-LOA-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	540.0	1.0E-162	792	1059	268

Status

Unreviewed

Ensembl Protein

ENSLAFP00000025575

UniProt Accession

G3UCL7;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000011658	ENSLAFP00000025575	ENSLAFT00000026176
ENSLAFG00000011658	ENSLAFP00000009741	ENSLAFT00000011661

Organism

Loxodonta africana

Functional Description

Protein Length

1161

Protein Sequence
(FASTA)

PLSPVCPSAC GKRACTENNE CCHAECLGSC SAPDNATACV ACRHYYYAGI CVPTCPPNTY 60

KFEGWRCVDR DFCANIPNAE SNDAEGFVIH DGECMQECPS GFIRNGTQSM YCIPCEGPCP 120

KVCEEEKKTK TIDSVTSAQM LQGCTIFKGN LLINIRRGNN IASELENFMG LIEVVTGYVK 180

IRHSHALVSL SFLKNLRQIL GEEQLEGNYS FYVLDNQNLQ QLWDWDHRNL TIKAGKMYFA 240

FNPKLCVSEI YRMEEVTGTK GRQSKGDINT RNNGERASCE SDVLHFTSTT TWKNRIIITW 300

HRYRPPDYRD LISFTVYYKE APFKNVTEYD GQDACGSNSW NMVDVDLPTN KDIEPGILLH 360

GLKPWTQYAV YVKAVTLTMV ENDHIRGAKS EILYIRTNAS VPSIPLDVLS ASNSSSQLIV 420

KWNPPSLPNG NLSYYIVRWQ RQPQDSYLYR HNYCSKEDKI PIRKYADGTI DVEEVTENPK 480

TEVCGGEKGP CCACPKTEAE KQAEKEEAEY RKVFENFLHN SIFVPRPERK RRDVMQVANP 540

TMSSRSRNTT MADTYNVTDP EELETEFPFF ESRVDNKERT VISNLRPFTL YRIDIHSCNH 600

EAEKLGCSAS NFVFARTMPA EGADDIPGPV TWESRPENSI FLKWPEPENP NGLILMYEIK 660

YGSQVEDQRE CVSRQEYRKY GGAKLNRLNP GNYTARIQAT SLSGNGSWTE PVFFYVPTKI 720

RPYENFIHLI ISVPVAALLI VGGLVIMLYV FHRKRNNSRL GNGVLYASVN PEYFSAADVY 780

VPDEWEVARE KITMSRELGQ GSFGMVYEGV AKGVVKDEPE TRVAIKTVNE AASMRERIEF 840

LNEASVMKEF NCHHVVRLLG VVSQGQPTLV IMELMTRGDL KSYLRSLRPE MEQNNPALAP 900

PSLSKMIQMA GEIADGMAYL NANKFVHRDL AARNCMVAED FTVKIGDFGM TRDIYETDYY 960

RKGGKGLLPV RWMSPESLKD GVFTTHSDVW SFGVVLWEIA TLAEQPYQGL SNEQVLRFVM 1020

EGGLLDKPDN CPDMLFELMR MCWQYNPKMR PSFLEIIGSV KDEMEPGFRE VSFYYSEENK 1080

PPEPEELDLE PENMESVPLD PSASSSSLPL PDRHSGHKAE NGPGPGVLVL RASFDERQPY 1140

AHMNGGRKNE RALPLPQSST C 1161

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 792   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  851

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeee.neaalappaldkliqmaa  119

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+e n++alapp+l+k+iqma+

Q: 852   CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMEqNNPALAPPSLSKMIQMAG  911

         ***************************************9989*****************

S: 120   eiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvr  179

         eiadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvr

Q: 912   EIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR  971

         ************************************************************

S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239

         wmspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+nc

Q: 972   WMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNC  1031

         ************************************************************

S: 240   pelltelmrlcwqynpklrpsfleivel  267

         p++l+elmr+cwqynpk+rpsflei+ +

Q: 1032  PDMLFELMRMCWQYNPKMRPSFLEIIGS  1059

         *************************976

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEM EQNNPALAPP SLSKMIQMAG 120

EIADGMAYLN ANKFVHRDLA ARNCMVAEDF TVKIGDFGMT RDIYETDYYR KGGKGLLPVR 180

WMSPESLKDG VFTTHSDVWS FGVVLWEIAT LAEQPYQGLS NEQVLRFVME GGLLDKPDNC 240

PDMLFELMRM CWQYNPKMRP SFLEIIGS 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0043559	; F:insulin binding
GO:0005010	; F:insulin-like growth factor-activated receptor activity
GO:0007420	; P:brain development
GO:0031017	; P:exocrine pancreas development
GO:0006955	; P:immune response
GO:0051389	; P:inactivation of MAPKK activity
GO:0048009	; P:insulin-like growth factor receptor signaling pathway
GO:0030238	; P:male sex determination
GO:0030879	; P:mammary gland development
GO:0043066	; P:negative regulation of apoptotic process
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0045740	; P:positive regulation of DNA replication
GO:0043410	; P:positive regulation of MAPK cascade
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060740	; P:prostate gland epithelium morphogenesis
GO:0046777	; P:protein autophosphorylation
GO:0051262	; P:protein tetramerization
GO:0046328	; P:regulation of JNK cascade

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013