| Tag | Content |
|---|
| EKPD ID | EKS-LOA-00118 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Met | 479.5 | 3.2E-144 | 1043 | 1303 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSLAFP00000029480 |
| UniProt Accession | Q108U6; |
| Protein Name | Hepatocyte growth factor receptor |
| Protein Synonyms/Alias | HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; |
| Gene Name | MET |
| Gene Synonyms/Alias | MET; |
| Ensembl Information | |
| Organism | Loxodonta africana |
| Functional Description | Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). |
| Protein Length | 1324 |
Protein Sequence
(FASTA) | | VTMKAPAVLA PGVLVLLFTL VRKSHGECEE ALAKSKMNVN MKYQLPNFTA DTPIQNVVLH 60 | | EHHIFLGAIN NIYVLNDKDL QKVAEYKTGP VLEHPDCLPC QDCSSKANLS GSVWKDNINM 120 | | ALLVDTYYDD QLITCGSVNR GTCQRHVLPP DNPADIHSKV HCMYSPQADE EPSKCPDCVV 180 | | SALGTKVLLT EKDRFINFFV GNTVNSSYLP DHSLHSISVR RLKETQDGFK FLTDQSYIDV 240 | | LPEFRDSYPI KYVHAFKHNQ FIYFLTVQRE TLESQTFHTR IIRFCSVDSG LHSYMEMPLE 300 | | CILTEKRRKR SAREEVFNIL QAAYVSKPGA YLAKQIGALP DDDILYGVFA QSKLDSAEPM 360 | | NRSAVCAFPI NHICLLVNES TRWQFHSTSS CALLPSHLTF RSPPRGCENK PEGYLKKKKS 420 | | YCHLFQLMAT STLQRVDLFT GQFNQVLLTS ISTFIKGNLT IANLGTSEGR FMQVCVSRTL 480 | | KFHPFHSCFS VGASNSRKHL EGGRTGNELR FPGGSKITKI PLDGLGCDHF QSCSQCLSAP 540 | | SFVQCGWCHN KCARAEECPN GMWTQEICLP TIYEVFPTSA PLEGGTTLTV CGWDFGFRRN 600 | | NKFDLKKTRV LIGNDSCTLT LSESTTTTES HFRDLFFRLK CTVGPAMNKH FNLSIIISNG 660 | | RGTARYRTFS YVEPVITSIS PSYGPKAGGT LVTLTGKYLN SGNSRHISIG GKTCTLKSVS 720 | | DSVLECYTPA QSISTDFPVK LKIDLANREA YSFSYQEDPT VYEIHPNKSF ISSILVFLSG 780 | | RHTMLAYSPS SCHSSCSVIR SHCNGHFRHK TKRCIHFPEH LMYSLQSWSS LSWFINGTGF 840 | | LPPELRAATT PLSLVSHVAP SLPPEYNNKG DYIDPEAVKG EVLKVGNKSC ENIHLQSEAV 900 | | LCTVPNDLLK LNSELNIEVG FLYFSHDIIS PSQASEGRSQ KSLLPIPPFG HALLLVKFAI 960 | | SLRLFLWLKK RKQIKVHSLL PTTFQDLNTF VTPRPHTDGL TNGDSDSSIP LLQNNVHIDL 1020 | | SALNPELVQA VQHVVIGPSS LIVHFNEVIG RGHFGCVYHG TLLDNGDKKI HCAVKSLNRI 1080 | | TDIGEVSQFL TEGIIMKDFS HPNVLSLLGI CLRSEGSPLV VLPYMKHGDL RNFIRNETHN 1140 | | PTVKDLIGFG LQVAKGMKYL ASKKFVHRDL AARNCMLDEK FTVKVADFGL ARDVYDKEYY 1200 | | SVHNKTGAKL PVKWMALESL QTQKFTTKSD VWSFGVLLWE LMTRGAPPYP DVNTFDITVY 1260 | | LLQGRRLLQP EYCPDPLYEV MLKCWHPKAE MRPSFSELVS RISAIFSTFI GEHYVHVNTT 1320 | | YVNV 1324 |
|
Nucleotide Sequence
(FASTA) | |
| Domain Profile | S: 1 vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp 60 | v+++eviG+GhfG+vy+g+l+d+ +kki++avksl+ritdi++v++fl+eg++mk+++hp | Q: 1043 VHFNEVIGRGHFGCVYHGTLLDNGDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 1102 | 799********************************************************* |
| S: 61 nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas 120 | nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas | Q: 1103 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 1162 | ************************************************************ |
| S: 121 kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt 180 | kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt | Q: 1163 KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT 1222 | ************************************************************ |
| S: 181 fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm 240 | +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm | Q: 1223 QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 1281 | **.********************************************************* |
| S: 241 lkcwkakpaerpqfsdlvsiis 262 | lkcw++k+++rp+fs+lvs+is | Q: 1282 LKCWHPKAEMRPSFSELVSRIS 1303 | ********************98 |
|
Domain Sequence
(FASTA) | | VHFNEVIGRG HFGCVYHGTL LDNGDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60 | | NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120 | | KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180 | | QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240 | | KCWHPKAEMR PSFSELVSRI S 261 |
|
| Keyword | ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |