EKS-LOA-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	477.8	7.2E-144	604	861	258

Status

Unreviewed

Ensembl Protein

ENSLAFP00000010004

UniProt Accession

G3T8I6;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA8

Gene Synonyms/Alias

EPHA8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000011971	ENSLAFP00000010004	ENSLAFT00000011971

Organism

Loxodonta africana

Functional Description

Protein Length

974

Protein Sequence
(FASTA)

VNLLDTSTIY GDWGWLTYPA HGWESINEVD ESFRPIHTYQ VCNVMSPNQN NWLRTSWVPR 60

DGARRVYAEI KFTLRDCNSM PGVLGTCKET FNLYYLESDR DLGARTQESQ FLKIDTIAAD 120

ESFTGADLGV RRLKLNTEVR GVGPLSKRGF YLAFQDIGAC LAILSLRIYY KKCPAMVRNL 180

AAFSEAVTGA DSSSLVEVRG QCVRHSEERD TPKMYCSAEG EWLVPIGKCV CSAGYEERRD 240

ACVACELGFY KSAPGDQLCA RCPPHSHSAA PAAQACRCDF SYYRAALDPP SSACTRPPSA 300

PVNLISSVNG TSVTLEWAPP LDPGGRSDIT YNAVCRRCPW ALNHCEACGS STRFMPQQTS 360

LVQASLLVAN LLAHMNYSFW IEAVNGVSDL SPEPRRAAVV NITTNQAAPS QVVVIRQERA 420

GQTSVSLLWQ EPEQPNGIIL EYEIKYYEKD KEMQSYSTLK AVTTRATVSG LKPGTRYVFQ 480

VRARTSAGCG RFSQAMEVET GKPRPRYDTR TIVWICLTLI TGLVVLLLLL ICKKRHCGYS 540

KAFQDSDEEK MHYQNGQAPP PVFLPLHHPP GKVPETQFYA ESHTYEEPGR AGRSFTREIE 600

ASRIHIEKII GSGESGEVCY GWLRVPGQQD VPVAIKALKP GYTERQRRDF LSEASIMGQF 660

DHPNIIRLEG VVTRGRLAMI VTEYMENGSL DAFLRTHDGQ FTIMQLVGML RGVGAGMRYL 720

SDLGYVHRDL AARNVLVDGN LVCKVSDFGL SRVLEDDPDA AYTTTGGKIP IRWTAPEAIA 780

FRTFSWASDV WSFGVVMWEV LAYGERPYWN MTNHDVISSV EEGYRLPAPM GCPRALHQLM 840

LDCWHKDRAQ RPRFSQIVSV LDALIRSPES LRVTATVNRC PPPAFAQSCF DLRGGGGGGG 900

GLTVGDWLDS IRMGRYRDHF AAGGYSSLGM VLRMNAQDVR ALGITLMGHQ KKILGSIQTM 960

RAQLTSTQEP HRHL 974

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++iek+iG+Ge Gevc G l++pg+++++vaik+lk g+te+qrrdflseasi+Gqfdhp

Q: 604   IHIEKIIGSGESGEVCYGWLRVPGQQDVPVAIKALKPGYTERQRRDFLSEASIMGQFDHP  663

         78**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+

Q: 664   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  723

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarn+lv+ nlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+

Q: 724   GYVHRDLAARNVLVDGNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  783

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         f+ asdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc

Q: 784   FSWASDVWSFGVVMWEVLAYGERPYWNMTNHDVISSVEEGYRLPAPMGCPRALHQLMLDC  843

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         w+kdra+rp+f+qivs+l

Q: 844   WHKDRAQRPRFSQIVSVL  861

         ***************985

Domain Sequence
(FASTA)

IHIEKIIGSG ESGEVCYGWL RVPGQQDVPV AIKALKPGYT ERQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120

GYVHRDLAAR NVLVDGNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180

FSWASDVWSF GVVMWEVLAY GERPYWNMTN HDVISSVEEG YRLPAPMGCP RALHQLMLDC 240

WHKDRAQRPR FSQIVSVL 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0043005	; C:neuron projection
GO:0005524	; F:ATP binding
GO:0005004	; F:GPI-linked ephrin receptor activity
GO:0007411	; P:axon guidance
GO:0016322	; P:neuron remodeling
GO:0043410	; P:positive regulation of MAPK cascade
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0033628	; P:regulation of cell adhesion mediated by integrin
GO:0006929	; P:substrate-dependent cell migration

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR020691	; EphrinA_rcpt8.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013