EPS-LOA-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	454.3	2.3E-136	128	454	327

Status

Unreviewed

Ensembl Protein

ENSLAFP00000010205

UniProt Accession

G3T8Y9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000012215	ENSLAFP00000010205	ENSLAFT00000012215

Organism

Loxodonta africana

Functional Description

Protein Length

653

Protein Sequence
(FASTA)

LGWLSSQTCF SICVTAFKAA ALIQRWYRRY VARLEMRRRC TWSIFQSIEY AGQQDQVKLH 60

DFFSYLVDHF TPSSHNERDF LNHMFTEERF LKDSEMEKCS DYDSIEVPDN YVGPHLSFPL 120

LPDHATALVE AFRLKQQLHA RYVLNLLHET RKHLIQLPNI NRVSTCYSEE ITVCGDLHGQ 180

LDDLIFIFYK GKNGLPSPER AYVFNGDFVD RGKDSMEILM VLFAFMLVYP KEFHLNRGNH 240

EDHMVNLRYG FTKEVMYKYK IHGKKILKTL QDVFSWLPLA TLVDEKVLIL HGGVSDMTDL 300

ELLAKLDRHK YSSTEVFPFP LSQPCNQHKS FTPPRDQVDR DAGELLEPTQ EEWKQVVDIL 360

WSDPMAQEGC KANTVRGGGC YFGPNVTEQL LQKYNLQFLI RSHECKPEGY EFCHNRKVLT 420

IFSASNYYEV GSNRGAYVKL GPALTPHIVQ YQANKTTHTL TTRQRISRVE ESALRALREK 480

LFAHSSDLLG EFKKHDADKT GLITLSDWAT AVESVLHLGL PWRMLRPQLV SSSTENVLEY 540

MSWLGDLAKG QLSRENIQSS LLETLYRNRS NLETIFRIID SDHSGFISLD EFRQTWKLFS 600

SHMNIDITDD CICDLARSID FNKDGHIDIN EFLEAFRLVE QSCSESNTSD LPQ 653

Nucleotide Sequence
(FASTA)

CTAGGGTGGC TCAGCTCACA GACTTGCTTC TCCATCTGTG TCACAGCCTT CAAGGCGGCG 60

GCCCTGATCC AGAGGTGGTA CCGGCGCTAC GTGGCACGCC TGGAGATGAG GCGGCGTTGC 120

ACCTGGAGCA TCTTCCAGTC TATAGAGTAT GCTGGGCAGC AAGACCAGGT CAAGCTCCAC 180

GATTTCTTCA GCTACCTCGT GGACCACTTC ACCCCCAGCA GCCACAACGA GAGGGACTTC 240

CTGAACCACA TGTTCACTGA GGAGAGATTC CTCAAGGACT CCGAGATGGA GAAATGCAGT 300

GACTATGACT CCATTGAGGT ACCGGACAAT TACGTGGGGC CACATCTCTC CTTTCCACTC 360

CTCCCGGACC ATGCAACTGC CCTAGTGGAA GCTTTCAGAC TGAAACAACA GCTCCATGCG 420

CGGTATGTCC TGAACCTCTT GCATGAAACC AGGAAGCACC TCATACAGCT GCCAAACATC 480

AACCGGGTCT CCACCTGTTA CAGCGAGGAG ATCACAGTGT GTGGAGACTT ACACGGCCAG 540

TTGGATGACT TAATATTTAT ATTTTATAAG GGGAAGAACG GCCTTCCGTC GCCAGAGCGG 600

GCCTACGTGT TCAATGGTGA CTTTGTGGAT CGAGGCAAGG ATTCAATGGA GATCCTGATG 660

GTTCTCTTCG CCTTCATGTT GGTTTACCCC AAAGAATTCC ATCTTAATCG AGGAAACCAT 720

GAGGACCATA TGGTGAACTT ACGATATGGC TTCACCAAGG AAGTGATGTA TAAATATAAG 780

ATACATGGCA AGAAAATACT AAAAACACTG CAAGATGTTT TCTCTTGGCT TCCGCTGGCT 840

ACTCTGGTTG ATGAGAAAGT CCTGATTCTT CATGGTGGTG TGTCAGACAT GACTGACCTG 900

GAGCTTCTGG CTAAACTAGA CAGACACAAG TATTCAAGTA CAGAAGTATT TCCTTTTCCC 960

TTAAGTCAAC CCTGCAATCA GCACAAATCG TTTACACCAC CCAGGGACCA AGTGGACCGT 1020

GACGCTGGAG AGCTGCTGGA GCCCACGCAG GAGGAGTGGA AGCAGGTCGT AGATATTCTT 1080

TGGAGTGATC CAATGGCTCA GGAGGGCTGC AAGGCTAACA CCGTCCGAGG AGGTGGCTGT 1140

TATTTTGGGC CTAATGTGAC AGAACAATTG CTACAGAAAT ACAACCTGCA ATTCCTAATC 1200

CGCTCTCACG AGTGCAAACC CGAAGGCTAT GAGTTCTGCC ACAACCGCAA GGTGCTAACC 1260

ATCTTTTCTG CCTCCAACTA CTATGAAGTT GGCAGTAACA GAGGAGCCTA TGTCAAATTG 1320

GGGCCAGCCC TAACCCCACA TATCGTGCAG TATCAAGCTA ACAAGACAAC TCACACACTA 1380

ACCACAAGGC AAAGGATTAG CAGAGTAGAG GAGTCAGCTC TGAGAGCACT TCGAGAAAAG 1440

TTATTTGCTC ATTCCTCAGA TCTTCTGGGT GAATTTAAGA AGCATGATGC AGATAAAACT 1500

GGTTTAATCA CCCTGAGTGA CTGGGCAACA GCCGTGGAGT CTGTGTTGCA TCTAGGGCTG 1560

CCATGGCGGA TGCTGAGGCC ACAGCTGGTG AGCAGCTCAA CAGAGAACGT GCTGGAGTAC 1620

ATGTCCTGGC TGGGGGACTT GGCCAAGGGA CAACTGAGCC GTGAGAACAT ACAGTCAAGC 1680

TTGCTGGAAA CACTGTATCG GAACCGATCC AACCTGGAGA CCATATTTAG GATCATAGAT 1740

AGTGATCACT CAGGGTTCAT CTCACTGGAT GAGTTCAGGC AGACCTGGAA GCTGTTCAGC 1800

TCTCACATGA ACATTGACAT CACGGATGAC TGCATCTGTG ACCTCGCCCG GAGTATTGAC 1860

TTCAACAAGG ATGGCCACAT CGACATCAAT GAGTTCCTGG AGGCCTTCCG CCTGGTAGAA 1920

CAGTCCTGCT CCGAGAGCAA CACCTCAGAT CTCCCACAG 1959

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ k++lha+yvl++l+e++k l qlpni++vst+ s+e+tv+GdlhG+lddl+++

Q: 128   LVEAFRLKQQLHARYVLNLLHETRKHLIQLPNINRVSTCYSEEITVCGDLHGQLDDLIFI  187

         89**********************************************************

S: 64    lk..knGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmna  121

         ++  knGlPs +++yvfnGdfvdrGk ++e+l+vl +++lv+P++ +lnrGnhed+++n+

Q: 188   FYkgKNGLPSPERAYVFNGDFVDRGKDSMEILMVLFAFMLVYPKEFHLNRGNHEDHMVNL  247

         *94459******************************************************

S: 122   ryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksve  181

         ryGf+kev+ kyk +gk+il++l++v+ wlPl+++vd++vl++hGG+s+ t+l+ll +++

Q: 248   RYGFTKEVMYKYKIHGKKILKTLQDVFSWLPLATLVDEKVLILHGGVSDMTDLELLAKLD  307

         ************************************************************

S: 182   rkkrksvllpPeessrd..........lgrldtdgepreslteteweqiidilwsdPrat  231

         r+k+ s  + P + s+           + ++d d+    + t++ew+q++dilwsdP a+

Q: 308   RHKYSSTEVFPFPLSQPcnqhksftppRDQVDRDAGELLEPTQEEWKQVVDILWSDPMAQ  367

         ******98888877766667788888877888877777777899****************

S: 232   nGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtifsasny  291

         +G+  nt+rG+G+yfGP+vte++l+ky+l+++irsheckpegye++h+ kv+tifsasny

Q: 368   EGCKANTVRGGGCYFGPNVTEQLLQKYNLQFLIRSHECKPEGYEFCHNRKVLTIFSASNY  427

         ************************************************************

S: 292   yeegsnkgayiklnsqltprfvqyiva  318

         ye+gsn+gay+kl   ltp++vqy++

Q: 428   YEVGSNRGAYVKLGPALTPHIVQYQAN  454

         ************************986

Domain Sequence
(FASTA)

LVEAFRLKQQ LHARYVLNLL HETRKHLIQL PNINRVSTCY SEEITVCGDL HGQLDDLIFI 60

FYKGKNGLPS PERAYVFNGD FVDRGKDSME ILMVLFAFML VYPKEFHLNR GNHEDHMVNL 120

RYGFTKEVMY KYKIHGKKIL KTLQDVFSWL PLATLVDEKV LILHGGVSDM TDLELLAKLD 180

RHKYSSTEVF PFPLSQPCNQ HKSFTPPRDQ VDRDAGELLE PTQEEWKQVV DILWSDPMAQ 240

EGCKANTVRG GGCYFGPNVT EQLLQKYNLQ FLIRSHECKP EGYEFCHNRK VLTIFSASNY 300

YEVGSNRGAY VKLGPALTPH IVQYQAN 327

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013