EKS-LOA-00351
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00351
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK359.31.8E-107167576410
StatusUnreviewed
Ensembl ProteinENSLAFP00000018731
UniProt AccessionG3T9W7;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000012693ENSLAFP00000018731ENSLAFT00000036026
ENSLAFG00000012693ENSLAFP00000010615ENSLAFT00000012694
OrganismLoxodonta africana
Functional Description
Protein Length613
Protein Sequence
(FASTA)
MLGDSSGPRE REAEGAGAAA VPAPPAIDFP AEGSDPKYDE SDVPAELQVL KGPLQQPTFP 60
FAVANQLLLV SLLEHLSHVH EPNPVRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 120
NRAIVHLMQS AKERVRQVSP KKMYFCLISR PREVAFEAQT SRYLNEFEEI AILGKGGYGR 180
VYKVRNKLDG QYYAIKKILI KGATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVA 240
QPQDRPSIQL PSLEMLSDQE DDRDQYEFKN DDSSSSSIIF AELTSDKEKA FGESGFENRS 300
NRLVNCSTNL VPRDAREFES SVELQEHGLS ITEHQLPLGH DSDLKENFTF TEESSEENVN 360
LFGRTEVQYH LMLHIQMQLC ERSLWDWITE RNRRGRECVD ESSCPYVMVS VATKIFQELV 420
EGVFYIHHMG IVHRDLKPRN IFLHGPDQQV KIGDFGLACT DILQKNTDWT NRNGKGMPTH 480
TSRVGTCLYA SPEQLEGSQY DTKSDMYSLG VILLELFQPF GTEMERAEVL AGLRIGQIPT 540
SLSKRCPVPA KYIQHLTRKN SSQRPSAVQL LQSELFQNSG NVNLTLQMKV IEQEKEIEEL 600
KRQLSLLSQD KGV 613
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59
         feei++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni
Q: 167   FEEIAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  226
         89**********************************************************
S: 60    vrYfaawleekeesl................................tdsseveaeaele  87
         v Y++aw+e+ +  +                                ++ss ++ae ++ 
Q: 227   VGYHTAWIEHVHVAQpqdrpsiqlpslemlsdqeddrdqyefknddsSSSSIIFAELTSD  286
         ************999999999999999888888888888888887743366677777777
S: 88    esesseesdtk.................................................  98
         +++++ es  +                                                 
Q: 287   KEKAFGESGFEnrsnrlvncstnlvprdarefessvelqehglsitehqlplghdsdlke  346
         777776666668899999999999999999999999999999999999999999999999
S: 99    .........................llyiqmelceketLkdwiderk......llesrse  127
                                  +l+iqm+lce ++L+dwi+er+      ++es++ 
Q: 347   nftfteesseenvnlfgrtevqyhlMLHIQMQLCE-RSLWDWITERNrrgrecVDESSCP  405
         9999999999*************************.9********999999989999999
S: 128   lvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLatalaeal  181
         +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa++++ ++
Q: 406   YVMvsvatKIFQELVEGVFYIHHMGIVHRDLKPRNIFLHgPDQQVKIGDFGLACTDILQK  465
         999************************************99*******************
S: 182   kedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfsteme  241
         ++d+++++ ++ ++ht++vgt+ly+sPeqle+sqY+ k+D++sLG+il+eL++pf teme
Q: 466   NTDWTNRNGKGMPTHTSRVGTCLYASPEQLEGSQYDTKSDMYSLGVILLELFQPFGTEME  525
         ************************************************************
S: 242   rvetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292
         r+e+l+ lr g+ip ++++++p+ +k++q+l+++++++Rpsa +ll+sel+
Q: 526   RAEVLAGLRIGQIPTSLSKRCPVPAKYIQHLTRKNSSQRPSAVQLLQSELF  576
         ************************************************986
Domain Sequence
(FASTA)
FEEIAILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60
VGYHTAWIEH VHVAQPQDRP SIQLPSLEML SDQEDDRDQY EFKNDDSSSS SIIFAELTSD 120
KEKAFGESGF ENRSNRLVNC STNLVPRDAR EFESSVELQE HGLSITEHQL PLGHDSDLKE 180
NFTFTEESSE ENVNLFGRTE VQYHLMLHIQ MQLCERSLWD WITERNRRGR ECVDESSCPY 240
VMVSVATKIF QELVEGVFYI HHMGIVHRDL KPRNIFLHGP DQQVKIGDFG LACTDILQKN 300
TDWTNRNGKG MPTHTSRVGT CLYASPEQLE GSQYDTKSDM YSLGVILLEL FQPFGTEMER 360
AEVLAGLRIG QIPTSLSKRC PVPAKYIQHL TRKNSSQRPS AVQLLQSELF 410
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CII-00191
EKS-CIS-00092
EKS-DAR-00704
EKS-EQC-00332
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-MAM-00345
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORA-00299
EKS-ORC-00319
EKS-ORL-00411
EKS-OTG-00345
EKS-PAT-00323
EKS-PES-00300
EKS-PEM-00181
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-SUS-00303
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XIM-00431
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013