EKS-LOA-00402

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00402

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	296.8	2.1E-88	1279	1536	258

Status

Unreviewed

Ensembl Protein

ENSLAFP00000010680

UniProt Accession

G3TYP2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000012768	ENSLAFP00000010680	ENSLAFT00000012773
ENSLAFG00000012768	ENSLAFP00000020700	ENSLAFT00000031668

Organism

Loxodonta africana

Functional Description

Protein Length

1543

Protein Sequence
(FASTA)

RQEYESGDTG CKNSESDLED FSDEINAENL YGTSPPSTPR QMKRMSAKHQ RNNAGRPASR 60

ANLKEKMNAP NQSPHKDTGK TVENVEEYSY KQEKKIRATL RTTERDHKKN VQCSFMLDSV 120

GGSLPKKSIP DVDLHKPYLS LGCSNAKLPV SMPMPIARTA RQTSRTDCPA DRLKFFETLR 180

LLLKLTSVSK KKDREQRGQE NTAFWFNRSN ELIWLELQAW HAGRTINDQD LFLYTARQAI 240

PDIINEILTF KVNYGSFASV RNGASFNGTS LEGQCNAPHE TKTVGYSTYH EHLQRQRVSF 300

EQVKRIMELL EYIEALYPSL QALQKDYEKY AAKDFQDRVQ ALCLWLNITK DLNQKLRIMG 360

TVLGIKNLSD IGWPVFEIPS PRPSKGNEAE DEGDDPEGDL EELESSADES EGEHTPGRTG 420

QEIRQPPENS VDIQPQDCVP KKLERLESEE DSAGWGAPDG STEVGFSRHC RTSIYRPFVD 480

KALKQMGLRK LILRLHKLMD GSLQRARIAL VKSDHPMEFS EFPDPMWGSD YVQLSSTPPS 540

SEQKCSAVSW EELNSMDLPS FEPAFSVLCR VLLNVIHECL KLRLEQRPAG EPSLLSIKQL 600

VRECKEVLKG GLLMKQYYQF MLHELLDGLE QTDRNMDAFE EDLHKMLMVY FDYMRSWIQM 660

LQQLPQASHS LKNLLEEEWN FTKEITHYIR GGEAQAGKLF CDIAGMLLKS TGSFLGSGLQ 720

ESCADDSSAA EEIRRSVIEI SRALKELFHE ARERASKALG FAKMLRKDLE IAAEFMLSAP 780

VRDLLDVLKS KQYVKIQIPG LENLQVFVPD SLAEEKSIIL QLLNAAAGKD CSKDSEDIVI 840

DAHLLLTKRS DPDQGSDDGW GTWQEPPVKV VPQAETVDTL RNVQVDNVLL VVMQSGHLTI 900

QRKAFQQSID GLMTLRQEQT SSQPVIAKAL QQLKNDALEL CNRISDAIDQ VDRMFISEFD 960

AEVDESESVT LQQYYREAMI QGYNFGFEYH KEVVRLMSGE FRQKIGDKYI SFARKWMNYV 1020

LTKCESGRGT RPRWATQGFD FLQAIEPAFI SALPEDDFLN LQALMNECIG HVIGKPHSPV 1080

TALHRNSPRP VKVPRCHSDP PNPHLIIPTP EGFSTRSVPS DARSHGSPAA AATATATAGR 1140

PSPSGSDSAP PKLTSSAPET RGSSVPENDR LASIAAELQF RSLSRHSSPT EERDEPAYPK 1200

GDSSASARRS WELRTLISQT KDTASKQGPI EAIQKSVRLF EEKRYREMRR KNIIGQVCDT 1260

PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD TGELMAMKEV SQPLIDLIVT 1320

FGTNEFAVQV LVAPGCMRFQ GNVKHRAEEM YIFMEYCDEG TLEEVSRLGL QEHVIRLYSK 1380

QITIAINVLH EHGIVHRDIK GANIFLTSSG LIKLGDFGCS VKLKNNAQTM PGEVNSTLGT 1440

AAYMAPEVIT RAKGEGHGRA ADIWSLGCVV IEMVTGKRPW HEYEHNFQIM YKVGMGHKPP 1500

IPEKLSPEGK DFLSHCLESD PKMRWTASQL LDHSFVKVCT DEE 1543

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Kev+ +p     + +v+  ++E ++ + l

Q: 1279  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEVS-QPLI---DLIVTFGTNEFAV-QVLVA  1333

         99******************************5.3433...3477777888876.67889

S: 61    enivkyyGv.eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         +  +++ G  +++ ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe

Q: 1334  PGCMRFQGNvKHRAEEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHE  1391

         9*******83555689****************884..7**********************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk  178

         ++ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1392  HGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITR  1451

         ********************************9988776256*****************9

S: 179   .kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegk  237

          k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipekls+egk

Q: 1452  aKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPEKLSPEGK  1510

         8899******************************************.*************

S: 238   dflekcleldpkkrpsaeeLLkhefl  263

         dfl++cle+dpk r++a++LL+h+f+

Q: 1511  DFLSHCLESDPKMRWTASQLLDHSFV  1536

         ************************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EVSQPLIDLI VTFGTNEFAV QVLVAPGCMR 60

FQGNVKHRAE EMYIFMEYCD EGTLEEVSRL GLQEHVIRLY SKQITIAINV LHEHGIVHRD 120

IKGANIFLTS SGLIKLGDFG CSVKLKNNAQ TMPGEVNSTL GTAAYMAPEV ITRAKGEGHG 180

RAADIWSLGC VVIEMVTGKR PWHEYEHNFQ IMYKVGMGHK PPIPEKLSPE GKDFLSHCLE 240

SDPKMRWTAS QLLDHSFV 258

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013