EKS-LOA-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	393.0	8.2E-118	29	294	266

Status

Unreviewed

Ensembl Protein

ENSLAFP00000011256

UniProt Accession

G3TBC1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000013443	ENSLAFP00000011256	ENSLAFT00000013448

Organism

Loxodonta africana

Functional Description

Protein Length

326

Protein Sequence
(FASTA)

ERLRTHSIES SGKLKISPEQ HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI 60

RSTVDEKEQK QLLMDLDVVM RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY 120

SVLDDVIPEE ILGKITLATV KALNHLKENL KIIHRDIKPS NILLDRSGNI KLCDFGISGQ 180

LVDSIAKTRD AGCRPYMAPE RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV 240

FDQLTQVVKG DPPQLTNSEE REFSPSFINF VNLCLTKDES KRPKYKELLK HPFILMYEER 300

TVEVACYVCK ILDQMPATPS SPMYVD 326

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 29    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  88

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 89    VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  147

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 148   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  207

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l ++   efs++f

Q: 208   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLTNSeerEFSPSF  267

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 268   INFVNLCLTKDESKRPKYKELLKHPFI  294

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLTNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013