EKS-LOA-00212
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00212
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2581.56.4E-175147503357
StatusUnreviewed
Ensembl ProteinENSLAFP00000027514
UniProt AccessionG3TBJ9;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000013575ENSLAFP00000011359ENSLAFT00000013573
ENSLAFG00000013575ENSLAFP00000027514ENSLAFT00000033671
OrganismLoxodonta africana
Functional Description
Protein Length572
Protein Sequence
(FASTA)
MSVRQALGRG LQLGRALLLR FTAKPGPIYG SCWGRGERPG PAAGPGAESR RLGLPNRFQF 60
FRQSVAGLAA RLQRQFVLRA GGGAGPCGRA VFLAFGLGLG LIEEKQAEGR RAASACQEIQ 120
AIFTQKNKLL PGPLDSKRWQ GFRLEEYLIG RSIGKGCSAA VYEATVPMVP QNLEGAESSG 180
LLTGRGPDII PQGETEEWTA QPSAFPLAIK MMWNISAGSS SEAILNTMSQ ELVPASRVAL 240
SGEYGAVTYW KSKGGAKQLA PHPNIIRVFR AFTSSVPLLP GALVDYPDVL PPRLHPDGLG 300
HGRTLFLVMK NYPCTLRQYL RMATPSPRLA TMMTLQLLEG VDHLVQQGIA HRDLKSDNIL 360
VELDADGCPW LVITDFGCCL ADERIGLQLP FTSWYVDRGG NGCLMAPEVS TACPGPWTVI 420
DYSKADAWAV GAIAYEIFGL SNPFYSQGRA HLESRSYQEA QLPALPESVP LDARHLVRSL 480
LQREASKRPS ARVAANVLHL SLWGEHILAL KNLKLDKMVG WLLQQSAATL LADRLTEKSC 540
VETKMKMLFL ANLECEALCQ AALLLQSWRA AP 572
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++gkgc+aavyeat++ ++q+le+a++ gll g++++ + +++ +e ++   +fp
Q: 147   YLIGRSIGKGCSAAVYEATVPMVPQNLEGAESSGLLtGRGPDIIPQGETEEWTAQPSAFP  206
         99********************************9989*********9999999999***
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPniv  111
         laik+m+ni+a+sssea+l++msqelvpasrval+geygav         k+la+hPni+
Q: 207   LAIKMMWNISAGSSSEAILNTMSQELVPASRVALSGEYGAVtywkskggAKQLAPHPNII  266
         *************************************************9**********
S: 112   rvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrs  171
         rv+raf++sv+llP+al+dyPd+lp+rl+p+glg+g+tl+lvmk+y++tlr+yl   ++s
Q: 267   RVFRAFTSSVPLLPGALVDYPDVLPPRLHPDGLGHGRTLFLVMKNYPCTLRQYLRMATPS  326
         ************************************************************
S: 172   trlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdg  231
         +rla+++++qlle+vdhlv++g+ahrdlksdnilveld d++P+lvi+dfGCclad+ +g
Q: 327   PRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVELDADGCPWLVITDFGCCLADERIG  386
         ************************************************************
S: 232   lrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyg  291
         l+lp++s++vd+GGn++lmaPe+sta pGp +vi+y+kad+WavGa+ayeifglsnPfy 
Q: 387   LQLPFTSWYVDRGGNGCLMAPEVSTACPGPWTVIDYSKADAWAVGAIAYEIFGLSNPFYS  446
         ************************************************************
S: 292   egkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         +g+a+les+syqeaqlPalpesvp ++r+lv++ll+reaskr+sa++aanvl+lsl+
Q: 447   QGRAHLESRSYQEAQLPALPESVPLDARHLVRSLLQREASKRPSARVAANVLHLSLW  503
         ********************************************************9
Domain Sequence
(FASTA)
YLIGRSIGKG CSAAVYEATV PMVPQNLEGA ESSGLLTGRG PDIIPQGETE EWTAQPSAFP 60
LAIKMMWNIS AGSSSEAILN TMSQELVPAS RVALSGEYGA VTYWKSKGGA KQLAPHPNII 120
RVFRAFTSSV PLLPGALVDY PDVLPPRLHP DGLGHGRTLF LVMKNYPCTL RQYLRMATPS 180
PRLATMMTLQ LLEGVDHLVQ QGIAHRDLKS DNILVELDAD GCPWLVITDF GCCLADERIG 240
LQLPFTSWYV DRGGNGCLMA PEVSTACPGP WTVIDYSKAD AWAVGAIAYE IFGLSNPFYS 300
QGRAHLESRS YQEAQLPALP ESVPLDARHL VRSLLQREAS KRPSARVAAN VLHLSLW 357
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013