EKS-LOA-00474
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00474
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK374.83.1E-112141427287
StatusUnreviewed
Ensembl ProteinENSLAFP00000011554
UniProt AccessionG3TC07;
Protein Name
Protein Synonyms/Alias
Gene NameNLK
Gene Synonyms/Alias NLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000013797ENSLAFP00000011554ENSLAFT00000013797
OrganismLoxodonta africana
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MSLCGTRANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA 60
VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QSYFPSPAPG QAPGPAAAAP AQVQAATAAT 120
VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 180
RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 240
VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 300
VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 360
SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 420
ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI 480
IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE 527
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63
          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++ 
Q: 141   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  200
         689*********************************************************
S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122
         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+
Q: 201   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  259
         *******9.**********************99879************************
S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182
         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+
Q: 260   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  319
         *********************************999************************
S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242
         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +
Q: 320   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  378
         ************************************************9996.7777777
S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl
Q: 379   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  427
         77666644457788888*******************************7
Domain Sequence
(FASTA)
DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60
LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120
LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180
AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240
HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00437
EKS-ANC-00455
EKS-BOT-00469
EKS-CAE-00389
EKS-CAJ-00474
EKS-CAF-00468
EKS-CAP-00500
EKS-CII-00264
EKS-CIS-00224
EKS-DAR-00879
EKS-DRM-00224
EKS-EQC-00457
EKS-FEC-00446
EKS-GAM-00274
EKS-GAG-00391
EKS-GAA-00573
EKS-HOS-00477
EKS-ICT-00450
EKS-LAC-00478
EKS-MAM-00466
EKS-MOD-00461
EKS-MUM-00500
EKS-MUP-00460
EKS-MYL-00462
EKS-NOL-00425
EKS-OCP-00122
EKS-ORN-00594
EKS-ORA-00403
EKS-ORC-00443
EKS-ORL-00537
EKS-OTG-00475
EKS-PAT-00439
EKS-PES-00411
EKS-POA-00455
EKS-PTV-00168
EKS-RAN-00481
EKS-SAH-00437
EKS-SOA-00050
EKS-SUS-00413
EKS-TAG-00530
EKS-TAR-00584
EKS-TAS-00067
EKS-TEN-00583
EKS-TUT-00172
EKS-XET-00618
EKS-XIM-00584
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004707; F:MAP kinase activity
GO:0030178; P:negative regulation of Wnt receptor signaling pathway
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0033136; P:serine phosphorylation of STAT3 protein
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013