EKS-LOA-00280

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00280

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	443.2	7.0E-133	196	524	329

Status

Unreviewed

Ensembl Protein

ENSLAFP00000011691

UniProt Accession

G3TCB7;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK3

Gene Synonyms/Alias

HIPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000013962	ENSLAFP00000011691	ENSLAFT00000013964
ENSLAFG00000013962	ENSLAFP00000022382	ENSLAFT00000026601

Organism

Loxodonta africana

Functional Description

Protein Length

1214

Protein Sequence
(FASTA)

MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCVFQERNY PRTYVNGRNF GNSHPLTKGS 60

AFQTKIPFNR PRGHNFSLKT SAVVLKNAAG ATKVIAQAQQ AQVEAPQIGA WRDRFSFLEG 120

PQRCGLKRKS EELDNHSSAM QIVDELSILP AMLQTNMGNP VTVVTATTGS KQNCTTGEGD 180

YQLVQHEVLC SMKNTYEVLD FLGRGTFGQV VKCWKRGTNE IVAIKILKNH PSYARQGQIE 240

VSILARLSTE NADEYNFVRA YECFQHRNHT CLVFEMLEQN LYDFLKQNKF SPLPLKVIRP 300

ILQQVATALK KLKSLGLIHA DLKPENIMLV DPIRQPYRVK VIDFGSASHV SKTVCSTYLQ 360

SRYYRAPEII LGLPFCEAID MWSLGCVIAE LFLGWPLYPG ALEYDQIRYI SQTQGLPGEQ 420

LLNVGTKSTR FFCRETDISH SGWRLKTLEE HEAETGMKSK EARKYIFNSL DDIVHVNTVM 480

DLEGSDLLAE KADRREFVSL LKKMLLIDAD LRITPAETLN HPFVNMKHLL DFPHSNHVKS 540

CFHIMDICKS HPNSCDTNNH SKTTLLRPVA SGNAANLAAN FTKIGTLRSQ ALTTSAHSVV 600

HHGIPLQAGT AQFGCGDAFQ QTLIICPPAI QGIPATHAKP TSYSIRVDNT VPLVTQAPAM 660

QPLQIRPGVL SQQTWSGRTQ QMLVPAWQQI TPMAPATTTL TSEGVAASQR LGDWGKMISH 720

SNHYNSVVPQ PLLTNQITLS APQPISVGIA HVVWPQPPTT KKNKLCQNRG ILVKLMEWEP 780

GREEVNAFSW SNSLQNTNIP HSAFISPKII NGKDVEEVSC IETQDNPNSA GEARNGCETS 840

VRQDSDSSGS DKQRQTIIIA DSPSPAVSVI TISSDTDEED TSQRHSLREC KGSLDCEACQ 900

STLNIDRMCS LSSPDSTLST SSSGQFSPSP CKRPNSMSDE EQESGCDTVD GSPTSESSGH 960

DSPFTESSFV ANTHQNTDLV TSADTKTKPA VCTVVVPPMG LQNGLNAELM ANTDSACQPL 1020

IKGRSVPGRL NQPSAVGSRQ QKLISAFQQQ PLNFSQVQHF GSGHQEWNGN FAHRRQQAYI 1080

PTSVTSHPFT LSHGSPGHTA VHAHLAGNTH LGGQATLLPY PSSAALSSAA PVAHLLASPC 1140

TSRPMLQHPT YSISHPSGIV HQVPVGINPR LLPSPTIHQT QYKPIFPPHS FIAASPAYTG 1200

FPLSPTKLSQ YPYM 1214

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 196   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  254

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+

Q: 255   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  314

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 315   LGLIHADLKPENIMLVDPIRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  374

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff

Q: 375   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFcr  434

         **********************************************************99

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t+ +++ ++lkt          ks++++k+++n  +++ ++++ ++ e ++ l+ek+d+

Q: 435   eTDISHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADR  494

         8888999999999999*******************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f++llk+ml +d++ Ritp+e+l+hpfv

Q: 495   ReFVSLLKKMLLIDADLRITPAETLNHPFV  524

         99***************************7

Domain Sequence
(FASTA)

YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60

NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120

GLIHADLKPE NIMLVDPIRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCRE 240

TDISHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIVH VNTVMDLEGS DLLAEKADRR 300

EFVSLLKKML LIDADLRITP AETLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009299	; P:mRNA transcription
GO:0043508	; P:negative regulation of JUN kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013