EKS-LOA-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.0	1.3E-149	686	943	258

Status

Unreviewed

Ensembl Protein

ENSLAFP00000022849

UniProt Accession

G3TD59;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000014393	ENSLAFP00000012058	ENSLAFT00000014401
ENSLAFG00000014393	ENSLAFP00000022849	ENSLAFT00000026393

Organism

Loxodonta africana

Functional Description

Protein Length

1178

Protein Sequence
(FASTA)

VCQGTSNKLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY VQRNYDLSFL KTIQEVAGYV 60

LIALNTVERI PLENLQIIRG NLLYENTYAL AVLSNYGANK TGVKELPMRN LQEILTGAVR 120

FSNNPVLCSI ETIQWRDIVD SDFISNMSMD LQSSQASCQK CAPSCPNGSC WGTGEENCQK 180

LTKTICAQQC SGRCRGKSPS DCCHNQCAAG CTGPRESDCL ICRKFRDEAT CKDTCPPLML 240

YNPTTYQMDV NPEGKYSFGA TCVKKCPHNY VVTDHGSCVR SCGSDSYEME EDGVRKCKKC 300

EGPCRKVCNG IGIGEFKDTL SINATNIKHF RNCTSISGDL HILPVAFKGD SFTRTPPLDP 360

KELDILKTVK EITGFLLIQA WPVNKTDLHA FENLEIIRGR TKQHHHSGQF SLAVVGLDIT 420

SLGLRSLKEI SDGDVIISGN RKLCYANTIN WKKLFGTSRQ NTKIINNRGE KDCKAVGYVC 480

NPLCSSEGCW GPEPKDCVSC RNVSRGRECV NKCNILEGEP REFVEKSECI QCHPECLPQP 540

MNITCTGRGP DSCIKCAHYI DGPHCVKTCP SGILGENNTL VWKYADASHV CHLCHPNCTF 600

GCAGPGLEGC ATNGPKIPSI ATGIVGGLLL LVVMALGIGL FMRRRHIVRK RTLRRLLQER 660

ELVEPVTPSG EAPNQALLRI LKETEFKKIK VLGSGAFGTV YKGLWIPEGE KVKIPVAIKE 720

LREATSPKAN KEILDEAYVM ASVDNPHVCR LLGICLTSTV QLITQLMPFG CLLDYVREHK 780

DNIGSQYLLN WCVQIAKGMN YLEDRRLVHR DLAARNVLVK TPQHVKITDF GLAKLLGAEE 840

KEYHAEGGKV PIKWMALESI LHRIYTHQSD VWSYGVTVWE LMTFGSKPYD GIPASEISSI 900

LEKGERLPQP PVCTIDVYMI MVKCWMIDAD SRPKFRELII EFSKMARDPQ RYLVIQGDER 960

MNLPSPTDSN FYRALMDEED MEDVVDADEY LIPQQGFFNS PSTSRTPLLN SLSAASNNST 1020

VACVDRNGSS PIKEDSFLQR YSSDPTGALT EESIDDSFLP VPEYINQSVP KRPAGSVQNP 1080

VYHNQPLNPA PGRDPHYQNP HSNAVENPEY LNTTEPACVN SPAYWAQKGN HQISLDNPDY 1140

QQDFFPKEAK PNGIFKVPAA ENAEYLRVAP PSSEFIGA 1178

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 686   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  745

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 746   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  805

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 806   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  865

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qpp+ctidvym++vkcw

Q: 866   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPVCTIDVYMIMVKCW  925

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 926   MIDADSRPKFRELIIEFS  943

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPVCTI DVYMIMVKCW 240

MIDADSRPKF RELIIEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016323	; C:basolateral plasma membrane
GO:0030139	; C:endocytic vesicle
GO:0005768	; C:endosome
GO:0016021	; C:integral to membrane
GO:0045121	; C:membrane raft
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0005006	; F:epidermal growth factor-activated receptor activity
GO:0030235	; F:nitric-oxide synthase regulator activity
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0000902	; P:cell morphogenesis
GO:0008283	; P:cell proliferation
GO:0016337	; P:cell-cell adhesion
GO:0021795	; P:cerebral cortex cell migration
GO:0048546	; P:digestive tract morphogenesis
GO:0001892	; P:embryonic placenta development
GO:0001942	; P:hair follicle development
GO:0060571	; P:morphogenesis of an epithelial fold
GO:0043066	; P:negative regulation of apoptotic process
GO:0042177	; P:negative regulation of protein catabolic process
GO:0035413	; P:positive regulation of catenin import into nucleus
GO:0030335	; P:positive regulation of cell migration
GO:0031659	; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739	; P:positive regulation of DNA repair
GO:0045740	; P:positive regulation of DNA replication
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0045429	; P:positive regulation of nitric oxide biosynthetic process
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141	; P:response to UV-A
GO:0007435	; P:salivary gland morphogenesis
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013