EKS-LOA-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	535.0	4.1E-161	731	1000	270

Status

Unreviewed

Ensembl Protein

ENSLAFP00000024128

UniProt Accession

G3TDJ2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000014602	ENSLAFP00000012237	ENSLAFT00000014610
ENSLAFG00000014602	ENSLAFP00000024128	ENSLAFT00000030271

Organism

Loxodonta africana

Functional Description

Protein Length

1237

Protein Sequence
(FASTA)

WTVLQGRIGR PENPFRVALE YISSGNRSLS AVDFFALKNC SEGTSPASKM ALQSSFTCWN 60

GTVLQLGQAC DFHQDCAQGE DEGQLCSNLP AGFYCDFEDG FCGWTQGTLL THTPRWLVRT 120

LKDARVQGYQ GQSLLLSTTD VPMSESATVT SATFPAPMKN SPLELRMSWL IRGVLRGNIS 180

LVLVENKTGK EEGRMVWHVA TNEGLSLWQW MVLPLLNVSD RFWLQIVAWW GQGSRATVAF 240

DNISISLDCY LTISGEDKMP QNTAPKSRNL FERNPNKELK PWENTPRETQ IFDPTVHWLF 300

TTCGASGPHG PTQAQCNNAY RNSNLSVMVG SEGPLKGIQI WKVPATDTYS ISGYGAAGGK 360

GGKNTMMRSH GVSVLGIFNL EKDDMLYILV GQQGEDACPS TSQLIQKVCV GENNVIEEEI 420

RVNRSVHEWA GGGGGGGGAT YPHSMKDGVP MPLIIAAGGG GRAYGAKTDT FHPERLENNS 480

SVLGLNGNSG AAGGGGGWND NTSLPWSGKS LLEGAIGGHS CPQAMKKWGW ETRGGFGGGG 540

GGCSSGGGGG GYIGGNAASN NDPEMDGEDG VSFISPLGIL YTPALKVMEG HGEVNIKHYL 600

NCSHCEVDEC HMDPESHKVI CFCDHGTVLA EDGVSCIVSP TPEPHLPLSL ILSVVTSALV 660

AALVLAFSGI MIVYRRKHQE LQAMQMELQS PEYKLSKLRT STIMTDYNPN YCFAGKISSI 720

SDLKEVPRKN ITLIRGLGHG AFGEVYEGQV SGMPNDPGPL QVAVKTLPEV CSEQDELDFL 780

MEALIISKFN HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLAMLD 840

LLHVARDIAC GCQYLEENHF IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK 900

GGCAMLPVKW MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG 960

GRMDPPKNCP GPVYRIMTQC WQHQPEDRPN FAIILERIEY CTQDPDVINT ALPIEYGPLM 1020

EEEEKVPMRP KDPEGIPPLL VSPQQAKREG EHCPTAPPPL PSTSSGRAGK KAAGAEVCVR 1080

GPRGPAGEGG HVNMAFSQSN PPTEVHKVQG SRNKPTSLWN PTYGSWFAEK PAAKKNDPVA 1140

ARKQQREQGK AGREGGCTAP PSAAAGRLAG ASLLLEPSSL TASIKEVPLF RLRHFPCGNV 1200

NYGYQQQGLP LEATAAPGTS NYKDSILKNK NVTQPGP 1237

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+ +l+vavktlpe++seqdeldfl+ealiiskfn

Q: 731   ITLIRGLGHGAFGEVYEGQVSGMPNDPGPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  790

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 791   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLAMLDLLHVARDIAC  850

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 851   GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  910

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 911   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  970

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 971   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  1000

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPGPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013