EKS-LOA-00310
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00310
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR454.89.8E-137708964257
StatusUnreviewed
Ensembl ProteinENSLAFP00000012397
UniProt AccessionG3TDW2;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000014798ENSLAFP00000012397ENSLAFT00000014805
OrganismLoxodonta africana
Functional Description
Protein Length1342
Protein Sequence
(FASTA)
MRANGALQVL GFLLSLARGS EVGSSQAVCP GTLNGLSVTG DAENQYQTLY KLYNRCEVVM 60
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
LNYNTNSSHA LRQLRFTQLT EILSGGVYIE RNEKLCHMDT IDWRDIVRHQ DAEIVVKENG 180
KSCPPCHEVC KGRCWGPGPE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240
TDCIACRHFN DSGACVRQCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQAS 300
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIEG 420
RSLYNRGFSL LIMKNLNITS LGLRSLREIS AGRIYISANR QLCYHHSLNW TKLLRGPAEE 480
RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 540
REFAHEAECF SCHPECEPME GAATCNGSGS DACAQCAHFR DGPHCVSSCH GVLGAKGPIY 600
KYPDVQNECR PCHENCTQGC KGPDLQDCLD QTQVPISKTH LAMALALVVG SLMIFLILGS 660
SFLYWRGRRI QNKRAMRRYL ERGESLEPLD PREKANKVLA RIFKETELRK LKVLGSGVFG 720
TVHKGVWIPE GESIKIPVCI KVIEDKSERQ SFQAVTDHMR AIGSLDHAHI VRLLGLCPGS 780
SLQLVTQYLP LGSLLDYVRE HRGALGPQLL LNWGVQIAKG MYYLEEHGMV HRNLAARNVL 840
LKSPSQVQVA DFGVADLLPP DDKQLLHSEA KTPIKWMALE SIHFGKYTHQ SDVWSYGVTV 900
WELMTFGAEP YAGLRLAEVP DLLEKGERLA QPQICTIDVY MVMVKCWMID ENIRPTFKEL 960
ANEFTRMARD PPRYLVIKRE SGPGIPPGAE PPALTNKELE EVELEPELDL DLDLEGEEDN 1020
LATTLGSALS LPVGTLTRPR GSQSLLSPSS GYMPMNQGNL GEACQESAVG GGSERCPRPA 1080
SLHPMPWRHL TSESSEGHVT GSEAELQEKA SMCRSRSRSR SRSPRPCGDS AYHSQRHSLL 1140
TPVTPLSPPG LEEEDINGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE DDEDEEYEYM 1200
NRRRKHSPPR PPRPSSLEEL GYEYMDLGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY 1260
EYMNRRRGGG DPGGDYASMG ACSAAEQGYE EMRAFRGPGY HAPNVHYTRL KTLRSLEATD 1320
SAFDNPDYWH SRLFPKTNAQ GT 1342
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k++++++++++d++ +++sldh
Q: 708   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSERQSFQAVTDHMRAIGSLDH  767
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lldyvreh+++lG+q llnw+vqiakGm+ylee+
Q: 768   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDYVREHRGALGPQLLLNWGVQIAKGMYYLEEH  827
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 828   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  887
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 888   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  947
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 948   MIDENIRPTFKELANEF  964
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS ERQSFQAVTD HMRAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDY VREHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAE-00255
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-DRM-00152
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-TAR-00393
EKS-TEN-00389
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00380
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013