EKS-LOA-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	387.7	3.9E-116	202	500	299

Status

Unreviewed

Ensembl Protein

ENSLAFP00000012732

UniProt Accession

G3TEP1;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000015201	ENSLAFP00000012732	ENSLAFT00000015205

Organism

Loxodonta africana

Functional Description

Protein Length

1036

Protein Sequence
(FASTA)

SSLRRPWRVP SLLLWAVLLV STAAASQNQE RLCAFKDPYQ QDLGIGESRI SHENGTILCS 60

KGSTCYGLWE KSKGDINLVK QGCWSHIGDP QECHYEECVV TTTPPSIQNG TYRFCCCSTD 120

LCNVNFTENF PPPDTTPLSP PHSFNQDETI IIALASVSAL AVLIVALCFG YRMLTGDRKQ 180

GLHSMNMMEA AASEPSLDLD NLKLLELIGR GRYGAVYKGS LDERPVAVKV FSFANRQNFI 240

NEKNIYRVPL MEHDNIARFI VGDERVTADG RMEYLLVMEY YPNGSLCKYL SLHTNDWVSS 300

CRLAHSVTRG LAYLHTELPR GDHYKPAISH RDLNSRNVLV KNDGTCVISD FGLSMRLTGN 360

RLVRPGEEDN AAISEVGTIR YMAPEVLEGA VNLRDCESAL KQVDMYALGL IYWEIFMRCT 420

DLFPGESVPE YQMAFQTEVG NHPTFEDMQV LVSREKQRPK FPEAWKENSL AVRSLKETIE 480

DCWDQDAEAR LTAQCAEERM AELMMIWERN KSVSPTVNPM STAMQNERNL SHNRRVPKIG 540

PYPDYSSSSY IEDSIHHTDS IVKNISSEHS MSSTPLTLGE KNRNSINYER QQAQARIPSP 600

ETSVTSLSTN TTTNTTGLTP STGMTTISEM PYSDETNLHA TNVAQPIGPT PVCLQLTEED 660

LETNKLDPKE VDKNLKESSD ENLMEHSLKQ FSGPDPLSST SSSLLYPLIK LAVEVTGQQD 720

FTQATNGQAC LIPDVPPTQI YPLPKQQNLP KRPTSLPLNT KNSTKEPRLK FGSKHKSNLK 780

QVETGVAKMN TINAAEPHVV TVTMNGVAGR NHSINSHVAT TQYANGVVPS GQTANTVAHR 840

AQEILQSQFI GEDTRLNINS SPDEHEPLLR REQQASHDEG VLDRLVDRRE RPLEGGRTNS 900

NNNNSNPCSE QDALTQGVPS TVPDPGPSKP RRAQRPNSLD LSATNILDGS SMQLGESTQD 960

GKSGSGEKIK KRVKTPYSLK RWRPSTWVIS TEPLDCEVNN NGSDRAVHSK SSTAVYLAEG 1020

GTATTMVSKD IGMNCL 1036

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 202   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  261

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t d+ +++rla+s+++Gla+LH+e++

Q: 262   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTNDWVSSCRLAHSVTRGLAYLHTELPRG  321

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 322   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  380

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 381   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  440

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 441   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  500

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTNDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0009267	; P:cellular response to starvation
GO:0048286	; P:lung alveolus development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0001707	; P:mesoderm formation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0003085	; P:negative regulation of systemic arterial blood pressure
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	; P:regulation of lung blood pressure
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013