EKS-LOA-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LOA-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	469.4	4.0E-141	17	279	263

Status

Unreviewed

Ensembl Protein

ENSLAFP00000023241

UniProt Accession

G3TF10;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000015369	ENSLAFP00000012880	ENSLAFT00000015371
ENSLAFG00000015369	ENSLAFP00000023241	ENSLAFT00000029174

Organism

Loxodonta africana

Functional Description

Protein Length

1297

Protein Sequence
(FASTA)

KDTINKIRDL RMKAEDYEVV KVIGRGAFGE VQLVRHKSSR KVYAMKLLSK FEMIKRSDSA 60

FFWEERDIMA FANSPWVVQL FYAFQDDRYL YMVMEYMPGG DLVNLMSNYD VPEKWARFYT 120

AEVVLALDAI HSMGFIHRDV KPDNMLLDKS GHLKLADFGT CMKMNKEGMV RCDTAVGTPD 180

YISPEVLKSQ GGDGYYGREC DWWSVGVFLY EMLVGDTPFY ADSLVGTYSK IMNHKNSLTF 240

PDDNDISKEA KNLICAFLTD REVRLGRNGV EEIKRHLFFK NDQWAWETLR DTVAPVVPDL 300

SSDIDTSNFD DLEEDKGDEE TFPIPKAFVG NQLPFVGFTY YSNRRYLSSA NPNDNRTSSN 360

VDKNLQESLQ KTIYKLEEQL HNEMQLKDEM EQKCRTSNIK LDKIMKELDE EGSQRRNLES 420

TVSQMEKEKM LLQHRINEYQ RKAEQENEKR RNVENEVSTL KDQLEDLKKV SQNSQLANEK 480

LAQLQKQLEE ANDLLRTESD TAARLRKSHT EMSKSISQLE SLNIELQERN RILENSKTQT 540

DKDYYQLQAV LDAERRDRGH DSEMIGDLQA RITSSQEEVK HLKHNLERLE GERKEAQDML 600

NHSEKEKNNL EIDLNYKLKS LQQRLEQEVN EHKVTKARLT DKHQSIEEAK SVAMCVEMEK 660

KLKEEREARE KAENRVVQIE KQCSMLDVDL KQSQQKLEHL TENKERMEEE VKNLTLQLEQ 720

ESNKRLLLQN ELKTQAFEAD NLKGLEKQMK QEINTLLEAK RLLEFELAQL TKQYRGNEGQ 780

MRELQDQLEA EQYFSTLYKT QVKELKEEIQ EKNRENLKKI QELQNEKETL ATQLDLAETK 840

AESEQLARGL LEEQYFELTQ ESKKAASRNR QEITDKDHTV SRLEEMNSML TRDIELLRKE 900

NEELTENMRK TEEEYKLKKE EEISNLKAAF EKNINTERTL KTQAVNKLAE IMNRKDFKID 960

RKKANTQDLR KKEKENRKLQ LELNQEREKF NQMVVKHQKE LNDMQAQLVE ECTHKNELQM 1020

QLASKESDIE QLRAKLLDLS DSTSVASFPS ADETDGNLPE SRIEGWLSVP NRGNIKRYGW 1080

KKQYVVVSSK KILFYNDEQE KEQSNPSMVL DIDPRLFYVR PVTQGDVYRA ETEEIPKIFQ 1140

ILYANEGECR KEVEMEPVQQ AEKTNFQNHK GHEFIPTLYH FPANCEACAK PLWHVFKPPP 1200

ALECRRCHVK CHRDHLDKKE DLISPCKVSY DVTSARDMLL LACSQDEQKK WVTHLVKKIP 1260

KNPPSGFVRA SPRTLSTRST ANQSFRKVVK NTSGKTR 1297

Nucleotide Sequence
(FASTA)

null 4

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+++kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 17    YEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  76

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 77    VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  134

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 135   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  193

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 194   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  253

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 254   ICAFLTDREVRLGRNGVEEIKRHLFF  279

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSSRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0003383	; P:apical constriction
GO:0032060	; P:bleb assembly
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0050901	; P:leukocyte tethering or rolling
GO:0022614	; P:membrane to membrane docking
GO:0016525	; P:negative regulation of angiogenesis
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0032970	; P:regulation of actin filament-based process
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013