EKS-LOA-00087
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00087
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PIKK452.98.6E-13622932618326
StatusUnreviewed
Ensembl ProteinENSLAFP00000012949
UniProt AccessionG3TF68;
Protein Name
Protein Synonyms/Alias
Gene NameATR
Gene Synonyms/Alias ATR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000015442ENSLAFP00000012949ENSLAFT00000015453
OrganismLoxodonta africana
Functional Description
Protein Length2643
Protein Sequence
(FASTA)
MGEHGLELAS MIPALRELGS ASPEDYNIVV QKPRQILCQF VDRILTDVNV VAVELIKKTD 60
SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH GQNEAKGSCI EFSNWIITRL LRIAASPSCQ 120
MLHKKICEVI CSLLFLFKSK SPAILGALTK ELLHLFEDLI YLHRRNAMGH SVEWPVVASR 180
FLSQVDEHMG YLQPAPLQFM SWQNLEFIEV TLLTVLIRII AIVFFRRQEL LLWQIGCALL 240
EYGSPKVKSL AIRLSTELFE LGGLPEQPAS TFFTSFFELL KRLVEMDADQ LKLYEEPLSK 300
LVKTLFPLEA EAYRNIEPVY LNMLLEKLCV MFEDGVLMRL KSDLLKAALC HLLQYFLKFV 360
PAGYESALPV RKVYVGNICR ALVDVLGVEG EAEYLLGPLY EALKMESMEI IEEVQCQTQQ 420
EKLSGNSDGI SPKRHQLSLS LSSSKRALKQ TEEIKHVDMS KKSILWSALR HKAESLQVIL 480
ECNSPDNPVI ETLEGITVVL QLTALCTVHC SHQNTDCHDF KDSQHKYKKK LSIVVTWMSL 540
DFYTKVLKAC RNLLESIKKP DLETVIDKVV KIYDALIYMQ VKSSFEDEIL KDLCGMLSLP 600
WIYPHSDDGA LKLTTFATNL LTLSQRISDS YSPQAQSRCV FLLTLFPRRI FLEWRTAVYN 660
WALQSSHEVI RASCVSGFFI LLQQQSSCNR APKILIDKVK DDSDIVKKEF ASILGQLVCT 720
LHGMFCLTSS LTEPFSEHGH VDLFCKNLKV TSQHECSSSR LKASVCKPFL FLLKKKTSSP 780
VKLAFIDNLH HLCKHLDFRE DETDVKIVLG TLLNLMEDPD KDVRVAFSGN IKHILGSLDS 840
EDGFIKELFV LRMKEAYTHA QISRNNELKD TLILTTGDIG RAAKGDLVPF ALLHLLHCLL 900
SKSASVSGAA YTEIRALVAA KSVKLQNFFS QYKKPICQFL VESLHSSQMT ALPSTPCQNA 960
EMRKQDVAHQ REMALNTLSE IANVFDFPDL NRFLTRTLQV LLPDLAAKAS PAASALIRTL 1020
GKQLNVNRRE ILINNFKYIF SHLVCSCSKD ELERALHYLK NETEIELGSL LRQDFQGLHN 1080
ELLLRIGEHY QQVFNGLSIL ASFASSDDPY QGPRDITSPE LMADYLQPKL LGILAFFNMQ 1140
LLSSSVGIED KKMALNSLMS LMKLMGPKHV SSVRVKMMTT LRTGLRFKDD FPELCCRAWD 1200
CFVRCLDHAY LGSLLSHVIV ALLPLIHVQP KETAAIFHYL IIENRDAVQD FLHEIYFLPD 1260
HPELETIKAV LQEYRKETSE STNLQTTLQL SMKAIQHENV DVRIHALTSL KETLYKNQEK 1320
LIKYATDSET VEPVISQLVT VLLKGCQDAN SQARLLCGEC LGELGAIDPG RLDFSTTETQ 1380
GKDFTFVTGV EDLGFAYGLL MELTRAYLAY ADNSRAQDSA AYAIQELLSI YDCREMQRDG 1440
PGHQLWRRFP EHVREILEPH LNTRYKSSQK STDWSGVKKP IYLSKLGNNF ADWSASWAGY 1500
LITKVRHDLA SKIFTCCSIM MKHDFKVTIY LLPHILVYVL LGCNQEDQQE VYAEIMAVLK 1560
HDDQHSINAQ DSASDLCQLS TQTVFSMLDH LTQWSRHKFQ TLKAEKFPQS KSHRDKVDAM 1620
ASTVDYEDYQ SVTRFLDLIP QDTLAVASFR SKAYTRAVMH FESFIIEKKQ NIQEHLGFLQ 1680
KLYAAMHEPD GVAGVSAIRK AEPSLKEQIL EHESIGLLRD ATACYDRAIQ LEPDQIIHYH 1740
GVVKSMLGLG QLSTVITQVN GVHANRSEWT DELNTYRVEA AWKLSQWDLV ENYLAADGKS 1800
TTWSVRLGQL LLSAKKRDTT AFYDTLKLVR AEQIVPLSAA SFERGSYQRG YEYIVRLHML 1860
CELEHSIRPL FHQSPGDSAQ EDSLNWVARL EMTQNSYRAK EPILALRRAL LSLNKRPDYS 1920
EMVGECWLQS ARVARKAGHH QTAYNALLNA GESRLAELYV ERAKWLWSKG DVHQALMVIQ 1980
KGVELCFPEN QSPAESKNML IHGRAILLVG RFMEETANFE SNAIMKKYKD VTLVLPEWED 2040
GHFYLAKYYD KLMPMVTDNK MEKQGDLIRY IVLHFGRSLQ YGNQFIYQSM PRMLSLWLDY 2100
GAKAYEWEKA GRSDRVQMRN DLAKINRVIT EHTNHLAPYQ FLTAFSQLIS RICHSHDEVF 2160
VVLMEIIAKV FLAYPQQAMW MMTAVSKSSY PMRVNRCKEI LNKAIHMKKS LEKFVGDATR 2220
LTDKLLELCN RPVDGSSSTL SMSIHFKMLK KLVEEATFSE ILIPLQSVMI PTLPSILGTH 2280
ANHEPFPGHW AYIAGFDDMV EVLASLQKPK KICLKGSDGK SYIMMCKPKD DLRKDCRLME 2340
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY 2400
MTGKELRQCM LPKSAALTEK LKVFQEFLLP RHPPIFHEWF LRTFPDPTSW YSSRSAYCRS 2460
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV 2520
NGMGPMGTEG LFRRACEVTL RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GNSKAHNETG 2580
EVVNEKAKTH VLDIEQRLQG VIKTHNRVTG LPLSIEGHVH YLIQEATDEN LLCQMYLGWT 2640
PYM 2643
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60
         iagfd++ve+las+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd
Q: 2293  IAGFDDMVEVLASLQKPKKICLKGSDGKSYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2352
         89**********************************************************
S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120
         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +
Q: 2353  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2404
         *************************************************........599
S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180
         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av
Q: 2405  ELRQCMLPKSAALTEKLKVFQEFLLPRHPP-IFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2463
         *****************************8.*****************************
S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240
         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+
Q: 2464  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2522
         *****************************************.******************
S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk....kkktsketeee  296
         +g++g+eG+fr++ce +lr++r+++e l+++L++fl+dplv+w+k    + k ++et+e+
Q: 2523  MGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEWSKpvkgNSKAHNETGEV  2582
         **********************************************998889999*****
S: 297   laekakaealkikkllskvekaenavatrdllllee  332
         ++ekak++ l+i+++l++v k++n+v+ ++l+++++
Q: 2583  VNEKAKTHVLDIEQRLQGVIKTHNRVTGLPLSIEGH  2618
         *******************************99987
Domain Sequence
(FASTA)
IAGFDDMVEV LASLQKPKKI CLKGSDGKSY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60
AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120
KSAALTEKLK VFQEFLLPRH PPIFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180
LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240
RRACEVTLRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGN SKAHNETGEV VNEKAKTHVL 300
DIEQRLQGVI KTHNRVTGLP LSIEGH 326
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00083
EKS-ANC-00083
EKS-BOT-00092
EKS-CAE-00084
EKS-CAJ-00093
EKS-CAF-00092
EKS-CII-00042
EKS-CIS-00095
EKS-DAR-00346
EKS-DRM-00045
EKS-EQC-00089
EKS-FEC-00086
EKS-GAG-00073
EKS-GAA-00114
EKS-GOG-00095
EKS-HOS-00093
EKS-LAC-00095
EKS-MAM-00090
EKS-MEG-00068
EKS-MOD-00089
EKS-MUM-00091
EKS-MUP-00092
EKS-MYL-00103
EKS-NOL-00086
EKS-ORN-00120
EKS-ORA-00073
EKS-ORC-00086
EKS-ORL-00112
EKS-OTG-00095
EKS-PAT-00082
EKS-PES-00079
EKS-PEM-00046
EKS-POA-00087
EKS-RAN-00088
EKS-SAH-00090
EKS-SUS-00081
EKS-TAG-00122
EKS-TAR-00126
EKS-TEN-00118
EKS-XET-00083
EKS-XIM-00118
EKS-SAC-00091
EKS-SCP-00090
Gene Ontology
GO:0001741; C:XY body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0071480; P:cellular response to gamma radiation
GO:0034644; P:cellular response to UV
GO:0000077; P:DNA damage checkpoint
GO:0006281; P:DNA repair
GO:0008156; P:negative regulation of DNA replication
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777; P:protein autophosphorylation
GO:0043393; P:regulation of protein binding
GO:0090399; P:replicative senescence
KEGG
InterPros
IPR011989; ARM-like.
IPR016024; ARM-type_fold.
IPR003152; FATC.
IPR011009; Kinase-like_dom.
IPR000403; PI3/4_kinase_cat_dom.
IPR018936; PI3/4_kinase_CS.
IPR003151; PIK-rel_kinase_FAT.
IPR014009; PIK_FAT.
IPR011990; TPR-like_helical.
IPR012993; UME.
Pfam
PF02259; FAT; 1.
PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
PF08064; UME; 1.
SMARTs
SM00146; PI3Kc; 1.
SM00802; UME; 1.
Prosites
PS51189; FAT; 1.
PS51190; FATC; 1.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
Prints
Created Date20-Feb-2013