EKS-LOA-00076
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00076
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK446.64.5E-13465348284
StatusUnreviewed
Ensembl ProteinENSLAFP00000029158
UniProt AccessionG3TF74;
Protein Name
Protein Synonyms/Alias
Gene NameGSK3A
Gene Synonyms/Alias GSK3A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000015460ENSLAFP00000029158ENSLAFT00000034540
ENSLAFG00000015460ENSLAFP00000012957ENSLAFT00000015461
OrganismLoxodonta africana
Functional Description
Protein Length428
Protein Sequence
(FASTA)
GSALGAMSGG ARPARSRNGG SASGPGAGTS FPPPGVKLGR DSGKVTTVVA TLGQGPERSQ 60
EVAYTDIKVI GNGSFGVVYQ ARLAETGELV AIKKVLQDKR FKNRELQIMR KLDHCNIVRL 120
RYFFYSGGEK KDELYLNLVL EYVPETVYRV ARHFTKAKLT IPIIYVKVYM YQLFRSLAYI 180
HSQGVCHRDI KPQNLLVDPD TAVLKLCDFG SAKQLVRGEP NVSYICSRYY RAPELIFGAT 240
DYTSSIDVWS AGCVLAELLL GQPIFPGDSG VDQLVEIIKV LGTPTREQIR EMNPNYTEFK 300
FPQIKAHPWT KVFKSRTPPE AIALCSSLLE YTPSSRLSPL EACAHSFFDE LRCPGTQLPN 360
NRPLPPLFNF SPGELSIQPS LNAILIPPHL RSPAGSATLT PSSQALGEPR LGSDRQPPDA 420
TATLTNSF 428
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61
         +++k+ig+GsFg+Vyqa+l+e+ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf
Q: 65    TDIKVIGNGSFGVVYQARLAETGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  123
         789**********************.**********************************
S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121
         f++  ekkd++ylnlvley+Pet+++v+r+++++k ++++++vk+y+yQlfr+lay+hs+
Q: 124   FYSGGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQ  183
         ************************************************************
S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181
         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt
Q: 184   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  243
         ************************************************************
S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241
         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++
Q: 244   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  303
         ************************************************************
S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286
         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff
Q: 304   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  348
         ********************************************9
Domain Sequence
(FASTA)
TDIKVIGNGS FGVVYQARLA ETGELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60
YSGGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPII YVKVYMYQLF RSLAYIHSQG 120
VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180
SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240
KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00074
EKS-ANC-00071
EKS-BOT-00080
EKS-CAJ-00082
EKS-CAF-00081
EKS-DAR-00331
EKS-EQC-00079
EKS-FEC-00077
EKS-GAM-00044
EKS-GAA-00099
EKS-GOG-00079
EKS-HOS-00083
EKS-LAC-00086
EKS-MAM-00080
EKS-MAE-00033
EKS-MUM-00081
EKS-MUP-00081
EKS-MYL-00088
EKS-NOL-00077
EKS-OCP-00051
EKS-ORN-00109
EKS-ORC-00076
EKS-ORL-00101
EKS-OTG-00084
EKS-PAT-00072
EKS-POA-00074
EKS-PRC-00044
EKS-PTV-00065
EKS-RAN-00077
EKS-SAH-00076
EKS-SUS-00072
EKS-TAR-00109
EKS-TUT-00070
EKS-XET-00076
EKS-XIM-00104
EKS-SAC-00071
EKS-SCP-00065
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003214; P:cardiac left ventricle morphogenesis
GO:0016477; P:cell migration
GO:0071285; P:cellular response to lithium ion
GO:0071407; P:cellular response to organic cyclic compound
GO:0044027; P:hypermethylation of CpG island
GO:0008286; P:insulin receptor signaling pathway
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0032007; P:negative regulation of TOR signaling cascade
GO:0051348; P:negative regulation of transferase activity
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway
GO:0030819; P:positive regulation of cAMP biosynthetic process
GO:2000467; P:positive regulation of glycogen (starch) synthase activity
GO:0045823; P:positive regulation of heart contraction
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0003073; P:regulation of systemic arterial blood pressure
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013