EPS-LOA-00058

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LOA-00058

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	242.4	4.6E-72	1	169	169

Status

Unreviewed

Ensembl Protein

ENSLAFP00000013076

UniProt Accession

G3TFG9;

Protein Name

Protein Synonyms/Alias

Gene Name

TNS3

Gene Synonyms/Alias

TNS3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLAFG00000015597	ENSLAFP00000013076	ENSLAFT00000015601
ENSLAFG00000015597	ENSLAFP00000026081	ENSLAFT00000032111

Organism

Loxodonta africana

Functional Description

Protein Length

1448

Protein Sequence
(FASTA)

MEDGHELDLT YITERVIAVS FPASSSEESY LHNLQDVTRM LKSKHGDNYL VLNLSEKRYD 60

LTKLNPKTMD VGWPDLHAPP LDKMCTICKA QESWLNSDPQ HVVVIHCRGG KGRIGVVISS 120

YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSGS VKMNASPLFL 180

HFVILHGIPN FDTGGVCRPF LKLYQAMQPV YTSGIYNVSP ENHSRVCIAI EPAQLLKGDI 240

MVKCYHKKYR SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NANRDDRFPD YGKIELVFSA 300

TPEKIQGSDH LHNDRGVIVD YNTADPLIRW DSYENLGADG EVLHTQGPVD GSLYAKVRKK 360

STSDPSIPGG PQAVPATHSP DHSDHTLSVS SDSGHSTASV RTDKTEERLA PGTKRGLSPQ 420

EKAELDQLLS GFGLEESESS FKDMTDAQSK YSGTRHVVPA QVHVNGDAKL RDRETDILDD 480

EMPNHDLHSV DSLGTLSSSE GQPLAHLGTF TCHKSSQNSL LSDGFGSNTG EDLPGSLGPD 540

LGIGMDLLYE RSFGNREPRQ PPALLRKPSV SAQTQTYGQS GYSTQTWVRQ QQMVAAHQYS 600

FTPEGEARPI SRSTAENAGL IPTQPRVPVT PTRGASSRVA VQRGVGSGPN PPETQLPPLG 660

KAFKPVFANE NAINGVGLEL NSVVSPGSPT LDIDQSIEQL NRLILELDPT FEPLPTHMNT 720

LGSQTNGAAP PDGVASRIRA SGRLQDPGEG PSRMPGRQVD DPLGGRHRKL SLGQYDNDVG 780

GQPSFSKCSW GKTTGVDQDP SMASFLDSAD TKETVITSYP SDIDVIDGRI FSPTKNGGES 840

ASSTPAFPVS PETPYVKTPP HYPQFQPLEP KMSNPASLYK GAHAPGCCPE ILSHFTGFYT 900

SPVHPKIVLL DSKCPTPPAL QCPRSSACYI PSRPNGGRRD SPSSAEHQWL ETSPKSTLSV 960

LGSSQPAGAL LGTSEFSGPM KDSPLLPHFQ PSELQGSFNS HELSLTEPLS EALATQSGPS 1020

FLSFSGAAVG SSLPPGETPG TLLANSHGVS PAPSAPLTAP GAVDNGFLPH HFLTVAPGHS 1080

GQHSPVLQGQ GMTLPGQPPL PEKKRASEGD RSFGSVSPSS SGFSSPHSGS TISIPFPNVL 1140

PDFSKASEAA SPLPDNPGDK LVTVKFVQDT SKYWYKPDIS REQAIAMLKD KEPGSFIVRD 1200

SHSFRGAYGL AMKVATPPPS VLQMNKKAGD LASELVRHFL IECTPKGVRL KGCPNEPYFG 1260

SLTALVYQHS ITPLALPCKL LIPDRDPLEE IAENSPQTAA NSAAELLKQG AACNVWYLNS 1320

VEMESLTGHQ AVQKALSITL VQEPPPISTV VHFKVSAQGI TLTDNQRKLF FRRHYPVNNV 1380

IFCALDPQDR KRWIKDGPSS KVFGFVARKQ GSTTDNVCHL FAEHDPEQPA SAIVNFVSKV 1440

MIGSPKKI 1448

Nucleotide Sequence
(FASTA)

ATGGAGGACG GCCATGAGCT GGACCTCACG TACATCACAG AGCGTGTCAT CGCTGTCTCC 60

TTCCCCGCCA GCAGCTCTGA GGAGTCCTAT CTCCACAACC TGCAGGATGT CACACGCATG 120

CTCAAGTCCA AGCATGGTGA CAACTACCTG GTATTAAACC TTTCTGAAAA GAGATATGAC 180

CTTACGAAGC TTAACCCAAA GACGATGGAT GTGGGCTGGC CGGACCTGCA CGCCCCACCC 240

CTGGATAAGA TGTGCACCAT ATGCAAAGCC CAGGAGTCCT GGCTCAACAG CGACCCCCAG 300

CATGTGGTGG TCATCCACTG CCGGGGTGGG AAAGGACGCA TAGGAGTGGT CATCTCCTCC 360

TACATGCACT TCACCAACGT CTCAGCCAGT GCCGACCAAG CCCTTGACAG ATTTGCAATG 420

AAGAAATTTT ATGATGATAA AGTTTCAGCT TTAATGCAGC CATCCCAAAA ACGGTATGTG 480

CAGTTCCTCA GTGGCCTCCT GTCTGGGTCG GTGAAAATGA ACGCCTCGCC ACTGTTCCTG 540

CATTTTGTCA TCCTGCACGG CATCCCCAAC TTCGACACAG GTGGAGTGTG CCGGCCCTTT 600

CTGAAGCTCT ACCAGGCCAT GCAGCCTGTC TACACGTCGG GGATCTACAA TGTCAGCCCG 660

GAAAACCACA GCAGGGTCTG CATCGCCATC GAGCCGGCGC AGCTCCTGAA GGGGGACATC 720

ATGGTCAAGT GTTACCACAA GAAGTACCGG TCGGCCACCC GCGACGTTAT CTTCCGCCTG 780

CAGTTTCACA CCGGGGCTGT CCAGGGCTAT GGGCTGGTGT TCGGAAAGGA GGATCTGGAT 840

AACGCTAACA GGGATGACCG TTTTCCTGAC TATGGGAAAA TCGAATTAGT CTTCTCAGCT 900

ACTCCTGAGA AGATCCAAGG GTCTGATCAT CTGCACAATG ACCGCGGAGT GATCGTCGAC 960

TACAACACCG CAGACCCACT GATTCGCTGG GACTCCTACG AGAACCTGGG CGCAGATGGA 1020

GAAGTGCTCC ACACGCAGGG GCCCGTCGAT GGCAGCCTCT ATGCTAAGGT GAGGAAGAAG 1080

AGTACCTCAG ACCCCAGCAT CCCAGGTGGC CCCCAGGCTG TTCCGGCCAC CCACAGCCCA 1140

GACCACAGCG ACCACACCCT GTCTGTCAGC AGTGACTCAG GCCACTCCAC CGCCTCAGTC 1200

AGGACTGACA AGACTGAAGA GCGCCTGGCT CCTGGCACCA AAAGGGGCCT GAGCCCACAG 1260

GAGAAGGCCG AGCTGGACCA GCTCCTCAGT GGCTTTGGCC TAGAAGAGTC TGAGAGCTCA 1320

TTCAAGGATA TGACTGATGC TCAGAGCAAA TATAGTGGGA CCCGCCATGT TGTGCCAGCC 1380

CAGGTCCATG TTAACGGGGA CGCCAAGCTG CGAGACAGGG AAACGGACAT CTTGGATGAC 1440

GAGATGCCCA ACCATGACCT ACACAGCGTG GATAGCCTCG GGACGTTGTC ATCTTCAGAG 1500

GGGCAGCCCT TGGCCCACCT CGGCACCTTC ACCTGCCACA AAAGCAGCCA GAACTCCCTC 1560

TTGTCTGATG GCTTTGGCAG CAACACTGGT GAAGACCTGC CTGGCAGCCT TGGCCCAGAC 1620

CTGGGCATTG GCATGGACCT GCTCTATGAG CGGTCCTTTG GAAACCGGGA GCCCCGGCAG 1680

CCACCGGCCC TGCTGAGGAA GCCCTCTGTG TCTGCACAGA CGCAGACCTA CGGGCAAAGC 1740

GGCTACTCCA CACAGACCTG GGTGCGCCAG CAGCAGATGG TAGCTGCACA CCAGTACAGC 1800

TTCACGCCCG AGGGGGAAGC CAGGCCCATC AGCCGCAGCA CAGCCGAAAA TGCCGGCCTC 1860

ATCCCGACCC AGCCCAGAGT GCCAGTCACC CCCACGCGCG GGGCTAGCAG CAGAGTGGCC 1920

GTCCAGAGGG GTGTAGGCAG TGGGCCGAAT CCCCCAGAAA CGCAGCTGCC ACCTCTCGGC 1980

AAAGCATTCA AACCCGTATT TGCAAATGAA AATGCCATAA ACGGGGTTGG CCTAGAACTG 2040

AACTCGGTTG TCTCACCAGG CTCCCCCACC CTGGACATCG ACCAGTCCAT TGAGCAGCTC 2100

AACAGGCTCA TCTTGGAGCT GGACCCCACC TTTGAGCCCC TTCCAACCCA CATGAACACG 2160

CTGGGCAGTC AGACCAACGG TGCCGCACCC CCAGACGGGG TGGCCAGCCG GATTCGGGCC 2220

AGCGGCAGGC TACAGGACCC AGGAGAGGGC CCCAGCAGGA TGCCCGGGAG GCAAGTTGAC 2280

GACCCCCTGG GTGGAAGACA CCGGAAGCTG AGCCTTGGGC AGTACGATAA TGATGTTGGC 2340

GGGCAGCCAT CCTTCTCCAA ATGCAGCTGG GGAAAGACCA CTGGTGTGGA CCAAGATCCA 2400

AGTATGGCAT CCTTCCTCGA TTCAGCGGAT ACCAAAGAGA CAGTGATCAC CAGTTACCCT 2460

TCAGACATTG ATGTGATCGA TGGCAGGATC TTCTCTCCAA CCAAAAATGG CGGTGAATCA 2520

GCCTCTTCAA CACCAGCATT TCCTGTGTCA CCAGAAACAC CGTATGTGAA GACCCCTCCC 2580

CACTATCCTC AGTTCCAACC CTTGGAGCCT AAGATGAGTA ACCCAGCCAG TCTGTACAAA 2640

GGAGCACATG CTCCAGGTTG CTGCCCAGAG ATTTTATCAC ATTTTACAGG ATTTTACACC 2700

TCTCCAGTGC ATCCAAAGAT TGTATTATTG GATTCTAAAT GTCCTACCCC CCCAGCTCTG 2760

CAGTGTCCCC GTTCATCTGC TTGCTACATT CCCAGCAGAC CAAATGGAGG TAGACGAGAC 2820

AGCCCTTCCT CTGCAGAGCA CCAGTGGTTA GAAACTAGCC CTAAATCCAC GCTTTCTGTG 2880

TTGGGGAGCA GCCAGCCAGC AGGGGCTCTC CTTGGCACCT CAGAGTTCTC CGGCCCCATG 2940

AAGGACTCCC CACTTCTGCC CCATTTCCAG CCTTCAGAGC TCCAGGGCTC TTTCAACAGC 3000

CACGAGCTCT CCCTGACAGA GCCATTGTCG GAAGCTCTGG CCACCCAGAG CGGCCCATCC 3060

TTCCTGAGCT TCAGTGGAGC TGCTGTGGGA AGTAGTCTTC CACCCGGGGA GACCCCGGGG 3120

ACCCTGCTGG CCAATTCCCA TGGAGTCTCA CCAGCCCCCA GTGCCCCGCT GACTGCCCCA 3180

GGGGCTGTCG ACAACGGCTT CCTGCCTCAT CACTTCCTCA CAGTCGCGCC TGGACACAGT 3240

GGCCAACACA GCCCGGTCTT GCAGGGTCAA GGGATGACCC TGCCCGGGCA GCCACCTCTT 3300

CCTGAGAAGA AGCGAGCCTC AGAGGGAGAC CGCTCCTTCG GCTCCGTCTC CCCTTCCTCC 3360

AGCGGCTTCT CCAGCCCCCA CAGCGGGAGC ACCATCAGCA TCCCCTTCCC AAACGTCCTT 3420

CCGGACTTCT CCAAAGCTTC AGAAGCAGCA TCCCCTTTGC CAGATAATCC AGGTGATAAA 3480

CTTGTGACAG TGAAATTTGT CCAAGACACA TCCAAGTACT GGTACAAGCC AGATATTTCA 3540

CGAGAACAAG CCATTGCCAT GTTGAAGGAC AAGGAGCCTG GGTCATTCAT CGTGCGGGAC 3600

AGCCATTCCT TTCGCGGCGC CTACGGCCTG GCCATGAAGG TGGCCACTCC CCCGCCTTCA 3660

GTCTTACAGA TGAACAAGAA AGCTGGAGAT TTGGCCAGTG AACTCGTCCG GCACTTTTTG 3720

ATTGAGTGTA CCCCGAAGGG AGTGCGGTTG AAAGGGTGCC CGAATGAACC GTACTTCGGG 3780

AGCCTGACGG CTTTGGTATA TCAACATTCA ATCACCCCGT TGGCCTTGCC CTGCAAACTG 3840

CTCATTCCAG ACAGAGATCC GCTGGAGGAA ATAGCAGAAA ATTCTCCCCA AACAGCTGCC 3900

AACTCAGCAG CTGAACTGCT GAAGCAGGGG GCAGCCTGCA ACGTGTGGTA CCTGAACTCT 3960

GTGGAAATGG AGTCCCTCAC AGGCCACCAA GCAGTGCAGA AGGCCCTAAG CATCACCTTG 4020

GTCCAGGAGC CTCCTCCCAT CTCCACAGTT GTCCACTTTA AGGTGTCTGC CCAGGGCATC 4080

ACGCTGACGG ACAATCAGAG GAAGCTCTTC TTCCGGAGGC ACTACCCTGT TAACAACGTG 4140

ATCTTCTGCG CCTTGGATCC ACAAGACAGG AAAAGGTGGA TCAAAGATGG CCCTTCCTCA 4200

AAGGTCTTTG GGTTTGTGGC CCGAAAGCAA GGCAGCACCA CAGACAACGT GTGCCACCTG 4260

TTTGCAGAGC ACGACCCTGA GCAGCCAGCC AGTGCCATCG TGAACTTTGT ATCAAAGGTC 4320

ATGATCGGGT CCCCAAAGAA GATTTGA 4347

Domain Profile

S: 4     tedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserry  63

         +edg +ldlty+ter+iavsfPa+++ee y  nl++v r+l+skh ++y++ nl se+ry

Q: 1     MEDGHELDLTYITERVIAVSFPASSSEESYLHNLQDVTRMLKSKHGDNYLVLNL-SEKRY  59

         79****************************************************.*****

S: 64    dltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivc  123

         dltkln+k +++g++dl+aP+l+k+++ick+ + Wl+ d+++vvv+hc+ggkgr+Gv+++

Q: 60    DLTKLNPKTMDVGWPDLHAPPLDKMCTICKAQESWLNSDPQHVVVIHCRGGKGRIGVVIS  119

         ************************************************************

S: 124   ayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         +y++++++sa+ad+ald+f+++++++dkv++  qPsq+ryv++ s+ll+g

Q: 120   SYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSG  169

         ***********************************************987

Domain Sequence
(FASTA)

MEDGHELDLT YITERVIAVS FPASSSEESY LHNLQDVTRM LKSKHGDNYL VLNLSEKRYD 60

LTKLNPKTMD VGWPDLHAPP LDKMCTICKA QESWLNSDPQ HVVVIHCRGG KGRIGVVISS 120

YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSG 169

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016477	; P:cell migration
GO:0048286	; P:lung alveolus development
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011993	; PH_like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR013625	; PTB.
IPR006020	; PTyr_interaction_dom.
IPR000980	; SH2.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF08416	; PTB; 1.
PF10409	; PTEN_C2; 1.
PF00017	; SH2; 1.

SMARTs

SM00462	; PTB; 1.
SM00252	; SH2; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50001	; SH2; 1.

Prints

Created Date

20-Feb-2013