EKS-LOA-00413
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00413
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR584.21.2E-175613946334
StatusUnreviewed
Ensembl ProteinENSLAFP00000013080
UniProt AccessionG3TFH2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000015599ENSLAFP00000022768ENSLAFT00000028503
ENSLAFG00000015599ENSLAFP00000013080ENSLAFT00000015605
OrganismLoxodonta africana
Functional Description
Protein Length996
Protein Sequence
(FASTA)
KDKMSGPGPR KLLALTVFSA MICGTFTNQE LPVIKCVLIN HKNNDSSVGL SSSYPMVSRS 60
AEDLGCSPRP ESTELIYEAD KVEVDVSASI TLQVMVSVPG NISCLWIFKH SFLSCQPNFD 120
LQNRGVVSMV ILKMTETEAG EYLLFIQSEA SNYTILFTVS IRTLDTPIYT LRRPYFRKME 180
NQDALLCISE SIPEPVVEWV FCNSQSESCK EESPAVVKKE EKVLHELFGT DIRCCAKNEL 240
GRECTKLFTI DLNNTPQTTL PQLFLKVGEP LWIRCKAVYI NHRFELKWEL GNKTLTEDSY 300
FEMSTYSTNR TMIRILFAFV SSVGRNDTGP YTCSSSEHPS KSTLVTIVDK GFINGSNSTE 360
DYEIDQHEEF CFSVRFKAYP QIKCTWTFSR KSFPCEQSSL EDGYSISKFC NHRHQPGEYI 420
FHAENDDAQF TKMFTLNIKR KPQVLAEAST SQASCSSDGY PLPSWTWKKC SEKSPNCTEE 480
ITEGIWNKKA HRKVFGRWVS SSTLNISEAV KGFLVKCCAY NSMGSSCETI PLNSPGPFSF 540
IQDNISFYTT IGLCLLFIAV LTMLLYHKYK KQFRYESQLQ MVQVTGSLDN EYFYIDFREF 600
EYDLKWEFPR ENLEFGKVLG SGAFGKVMNA TAYGISKTGV SIQVAVKMLK EKADSSEKEA 660
LMSELKMMTH LGSHENIVNL LGACTLSGPI YLIFEYCCYG DLLNYLRSKR EKFHRTWTEI 720
FKEHNFSFYP TFQSQSNPSM PGSREVKIQQ DLDQISGFNG NSFHSEDEIE YENQKRLEEE 780
EDLNVLTFED LLCFAYQVAK GMEFLEFKSC VHRDLAARNV LVTHGKVVKI CDFGLARDIM 840
SDSNYVVRGN ARLPVKWMAP ESLFEGIYTI KSDVWSYGIL LWEIFSLGVN PYPGIPVDAN 900
FYKLIQSGFK MDQPFYATEE IYFIMQSCWA FDSRKRPSFP NLTSFLGCQL ADAEEAMYQN 960
MDGHTLEHPS LYQHRRPCSQ EMNSGAPLPQ AQAEDS 996
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+ssekealmselk+++hlG
Q: 613   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEKEALMSELKMMTHLG  672
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 673   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  731
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+s+ s+++s+e v++++d++++s ++ ++++se++ +++++++   +eeed
Q: 732   ------FQSQSNPSMPGSRE-VKIQQDLDQISGFNGNSFHSEDEIEYENQKRL--EEEED  782
         ......99************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 783   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  842
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 843   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  902
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 903   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  946
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEKEALM SELKMMTHLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSQSNPSMPG SREVKIQQDL DQISGFNGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013