EKS-LOA-00088
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LOA-00088
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PIKK444.14.3E-13321542478325
StatusUnreviewed
Ensembl ProteinENSLAFP00000013128
UniProt AccessionG3TFL3;
Protein Name
Protein Synonyms/Alias
Gene NameMTOR
Gene Synonyms/Alias MTOR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLAFG00000015635ENSLAFP00000013128ENSLAFT00000015655
OrganismLoxodonta africana
Functional Description
Protein Length2546
Protein Sequence
(FASTA)
MLGTGPAAAT TATTTSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 60
TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN ATRIGRFANY LRNLLPSNDP 120
VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP 180
TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 240
AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 300
KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGTSPS PAKSTLVESR 360
CCRDLMEEKF DQVCQWVLKC RNSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 420
LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKAMQVDA 480
TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 540
KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVG SITLALRTLG SFEFEGHSLT 600
QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL 660
VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 720
MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 780
LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD SSLLAKRQVA 840
LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 900
VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 960
DQSLSQHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 1020
SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 1080
VFMHDNSSGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEVPLP SRKAALETVD 1140
RLTESLDFTD YASRIIHPIV RTLDQSPELR PTAMDTLSSL VFQLGKKYQI FIPMVNKVLV 1200
RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSG QGDALASGPV ETGPMKKLHV 1260
STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 1320
AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 1380
VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAA GVLDYAMKHF 1440
GELEIQATWY EKLHEWEDAL VAYDKKVDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK 1500
WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 1560
QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW 1620
ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD 1680
PSRQLDHPLP TVHPQVTYAY MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK 1740
QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA 1800
VLHYKHQNQA RDEKKKLRHT SGANITNTTT AATMAATATA TATSTEGSNS ESEAESTENS 1860
PTPSPLQKKV TEDLSKTLLM YTVPAVQGFF RSISLSRGNN LQDTLRVLTL WFDYGHWPDV 1920
NEALVEGVKA IQIDTWLQVI PQLIARIDTP RPLVGRLIHQ LLTDIGRYHP QALIYPLTVA 1980
SKSTTTARHN AANKILKNMC EHSNTLVQQA MMVSEELIRV AILWHEMWHE GLEEASRLYF 2040
GERNVKGMFE VLEPLHAMME RGPQTLKETS FNQAYGRDLM EAQEWCRKYM KSGNVKDLTQ 2100
AWDLYYHVFR RISKQLPQLT SLELQYVSPK LLMCRDLELA VPGTYDPNQP IIRIQSIAPS 2160
LQVITSKQRP RKLTLMGSNG HEFVFLLKGH EDLRQDERVM QLFGLVNTLL ANDPTSLRKN 2220
LSIQRYAVIP LSTNSGLIGW VPHCDTLHAL IRDYREKKKI LLNIEHRIML RMAPDYDHLT 2280
LMQKVEVFEH AVNNTAGDDL AKLLWLKSPS SEVWFDRRTN YTRSLAVMSM VGYILGLGDR 2340
HPSNLMLDRL SGKILHIDFG DCFEVAMTRE KFPEKIPFRL TRMLTNAMEV TGLDGNYRIT 2400
CHTVMEVLRE HKDSVMAVLE AFVYDPLLNW RLMDTNTKGN KRSRTRTDSY SASQSVEILD 2460
GVELGEPAHK KTGTTVPESI HSFIGDGLVK PEALNKKAIQ IINRVRDKLT GRDFSHDETL 2520
DVPIQVELLI KQATSHENLC QCYIGW 2546
Nucleotide Sequence
(FASTA)
null 4
Domain Profile
S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60
         i+++++++++++skq+p+kl+l+Gs+g+e+++L+kg+eDlrqderv+qlf+lvNtlLa+d
Q: 2154  IQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLAND  2213
         899*********************************************************
S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120
         +++ r++L+i++y+V+plst+sgli+wv+++++L++l+++++ekk++ll+        ++
Q: 2214  PTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN-------IEH  2266
         *************************************************9.......9**
S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178
         +++ +++p+++hl+l+  +evf+++++n ++ d l+kll+ k+ps+e+wf++r++ytrsl
Q: 2267  RIMLRMAPDYDHLTLMqkVEVFEHAVNN-TAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL  2325
         ****************************.999****************************
S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238
         Av+s+vgyiLgLgdrh++nl++d+ +g+++hidfg +fe a+t++k+pek+PFRLTr+++
Q: 2326  AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT  2385
         ************************************************************
S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeela  298
         na++vtg++G++r++c++v++vlre+k++++++Le+f+ydpl++w+ +++++k+++++++
Q: 2386  NAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRT  2445
         ************************************************************
S: 299   ekakaealkikkllskvekaenavatrdlllle  331
         ++++++a +++++l++ve +e+a+++++++++e
Q: 2446  RTDSYSASQSVEILDGVELGEPAHKKTGTTVPE  2478
         ****************************99987
Domain Sequence
(FASTA)
IQSIAPSLQV ITSKQRPRKL TLMGSNGHEF VFLLKGHEDL RQDERVMQLF GLVNTLLAND 60
PTSLRKNLSI QRYAVIPLST NSGLIGWVPH CDTLHALIRD YREKKKILLN IEHRIMLRMA 120
PDYDHLTLMQ KVEVFEHAVN NTAGDDLAKL LWLKSPSSEV WFDRRTNYTR SLAVMSMVGY 180
ILGLGDRHPS NLMLDRLSGK ILHIDFGDCF EVAMTREKFP EKIPFRLTRM LTNAMEVTGL 240
DGNYRITCHT VMEVLREHKD SVMAVLEAFV YDPLLNWRLM DTNTKGNKRS RTRTDSYSAS 300
QSVEILDGVE LGEPAHKKTG TTVPE 325
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00084
EKS-BOT-00093
EKS-CAE-00082
EKS-CAF-00093
EKS-CAP-00089
EKS-CII-00038
EKS-CIS-00094
EKS-DAR-00344
EKS-DRM-00041
EKS-EQC-00090
EKS-FEC-00087
EKS-GAG-00074
EKS-GAA-00112
EKS-GOG-00090
EKS-HOS-00094
EKS-ICT-00085
EKS-LAC-00096
EKS-MAM-00094
EKS-MEG-00069
EKS-MOD-00090
EKS-MUM-00092
EKS-MUP-00093
EKS-MYL-00102
EKS-ORN-00119
EKS-ORA-00074
EKS-ORC-00085
EKS-ORL-00111
EKS-OTG-00096
EKS-PAT-00083
EKS-PES-00078
EKS-RAN-00089
EKS-SUS-00082
EKS-TAG-00123
EKS-TAR-00125
EKS-TEN-00119
EKS-XET-00086
EKS-SAC-00088
EKS-SCP-00089
Gene Ontology
GO:0005829; C:cytosol
GO:0012505; C:endomembrane system
GO:0005764; C:lysosome
GO:0016020; C:membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0008144; F:drug binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043022; F:ribosome binding
GO:0001030; F:RNA polymerase III type 1 promoter DNA binding
GO:0001031; F:RNA polymerase III type 2 promoter DNA binding
GO:0001032; F:RNA polymerase III type 3 promoter DNA binding
GO:0071456; P:cellular response to hypoxia
GO:0031669; P:cellular response to nutrient levels
GO:0007281; P:germ cell development
GO:0045792; P:negative regulation of cell size
GO:0016242; P:negative regulation of macroautophagy
GO:0051534; P:negative regulation of NFAT protein import into nucleus
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0030838; P:positive regulation of actin filament polymerization
GO:0010592; P:positive regulation of lamellipodium assembly
GO:0046889; P:positive regulation of lipid biosynthetic process
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051496; P:positive regulation of stress fiber assembly
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045859; P:regulation of protein kinase activity
GO:0032314; P:regulation of Rac GTPase activity
GO:0043200; P:response to amino acid stimulus
GO:0032868; P:response to insulin stimulus
GO:0031529; P:ruffle organization
GO:0031929; P:TOR signaling cascade
KEGG
InterPros
IPR011989; ARM-like.
IPR016024; ARM-type_fold.
IPR024585; DUF3385_TOR.
IPR003152; FATC.
IPR011009; Kinase-like_dom.
IPR000403; PI3/4_kinase_cat_dom.
IPR018936; PI3/4_kinase_CS.
IPR003151; PIK-rel_kinase_FAT.
IPR014009; PIK_FAT.
IPR009076; Rapamycin-bd_dom.
IPR026683; TOR/Smg1.
Pfam
PF11865; DUF3385; 1.
PF02259; FAT; 1.
PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
PF08771; Rapamycin_bind; 1.
SMARTs
SM00146; PI3Kc; 1.
Prosites
PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; 1.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
Prints
Created Date20-Feb-2013